Research Output per year
Research Output per year
Personal profile
Scientific Focus
Our group is interested in the physiological role of tanycytes, a specialized population of glial cells in the ependymal layer of the 3rd ventricle. Our main focus is to clarify the role of tanycytes in the regulation of the energy homeostasis, the barrier function as well as their influence on the release of hormones of the hypothalamus-pituitary axis. To investigate these topics, we have established new genetic and viral tools to specifically manipulate tanycytic functions in vivo.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Academic qualification
Promotion, Promotion, University of Luebeck
01.04.2005 → 15.12.2009
Pharmazie, Staatsexamen, UROLOGIE Zentrum Kiel
01.10.1999 → 14.02.2005
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Short regulatory DNA sequences to target brain endothelial cells for gene therapy
Graßhoff, H., Müller-Fielitz, H., Dogbevia, G. K., Körbelin, J., Bannach, J., Vahldieck, C. M. G., Kusche-Vihrog, K., Jöhren, O., Müller, O. J., Nogueiras, R., Prevot, V. & Schwaninger, M., 01.2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 1, p. 104-120 17 p.Research output: Journal Articles › Journal articles › Research › peer-review
1 Citation (Scopus) -
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C. & Pfefferle, S. & 26 others, , 11.2021, In: Nature Neuroscience. 24, 11, p. 1522-1533 12 p.Research output: Journal Articles › Journal articles › Research › peer-review
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NF-κB signaling in tanycytes mediates inflammation-induced anorexia
Böttcher, M., Müller-Fielitz, H., Sundaram, S. M., Gallet, S., Neve, V., Shionoya, K., Zager, A., Quan, N., Liu, X., Schmidt-Ullrich, R., Haenold, R., Wenzel, J., Blomqvist, A., Engblom, D., Prevot, V. & Schwaninger, M., 09.2020, In: Molecular Metabolism. 39, p. 101022 101022.Research output: Journal Articles › Journal articles › Research › peer-review
1 Citation (Scopus) -
H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects
Krajka, V., Vulinovic, F., Genova, M., Tanzer, K., Jijumon, A. S., Bodakuntla, S., Tennstedt, S., Mueller-Fielitz, H., Meier, B., Janke, C., Klein, C. & Rakovic, A., 03.2022, In: Science Advances. 8, 10, p. eabj9229 eabj9229.Research output: Journal Articles › Journal articles › Research › peer-review
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Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
Müller-Fielitz, H., Stahr, M., Bernau, M., Richter, M., Abele, S., Krajka, V., Benzin, A., Wenzel, J., Kalies, K., Mittag, J., Heuer, H., Offermanns, S. & Schwaninger, M., 01.12.2017, In: Nature Communications. 8, 1, 484.Research output: Journal Articles › Journal articles › Research › peer-review
4 Citations (Scopus)
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CRC/Transregio TRR 296 LocoTact: Local control of TH action
Führer-Sakel, D. (Speaker, Coordinator), Mittag, J. (Second Speaker/Coordinator), Kühnen, P. (Second Speaker/Coordinator), Heuer, H. (Principal Investigator (PI)), Schwaninger, M. (Principal Investigator (PI)), Müller-Fielitz, H. (Principal Investigator (PI)), Bechmann, I. (Principal Investigator (PI)), Biebermann, H. (Principal Investigator (PI)), Müller, T. (Principal Investigator (PI)), Pfluger, P. (Principal Investigator (PI)), Krude, H. (Principal Investigator (PI)), Schülke-Gerstenfeld, M. (Principal Investigator (PI)), Cirkel, A. (Principal Investigator (PI)), Münte, T. (Principal Investigator (PI)), Kleinschnitz, C. (Principal Investigator (PI)), Langhauser, F. (Principal Investigator (PI)), Engel, D. R. (Principal Investigator (PI)), Möller, L. (Principal Investigator (PI)), Kaiser, F. (Principal Investigator (PI)), Oster, H. (Principal Investigator (PI)), Kirchner, H. (Principal Investigator (PI)), Spranger, J. (Principal Investigator (PI)), Tacke, F. (Principal Investigator (PI)), Wirth, E. K. (Principal Investigator (PI)), Köhrle, J. (Principal Investigator (PI)), Schomburg, L. (Principal Investigator (PI)), Lange, C. M. (Principal Investigator (PI)), Zwanziger, D. (Principal Investigator (PI)), Mayerl, S. (Principal Investigator (PI)) & Stachelscheid, H. (Principal Investigator (PI))
01.01.20 → …
Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios
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CRC/Transregio TRR 296 LocoTact, Project P02: Impact of TH on tanycyte functions and the relevance on central regulation of the liver and hormone uptake
Müller-Fielitz, H. (Principal Investigator (PI))
01.01.20 → …
Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios
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Role of Tanycytes in the non-classical feedback regulation of the hypothalamic-pituitary-thyroid axis
Müller-Fielitz, H. (Principal Investigator (PI))
01.09.15 → 31.12.22
Project: DFG Projects › DFG Individual Projects
Prizes
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Perfood Research Award 2021
Wenzel, J. (Award Recipient), Lampe, J. (Award Recipient) & Müller-Fielitz, H. (Award Recipient), 21.11.2021
Prize: Awards of the University of Luebeck
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