Scientific Focus

Prof. Busch studied Theoretical Physics at the Technical University of Darmstadt, Germany, and Trinity College Dublin, Ireland. After finishing his PhD in 2004, dealing with numerical simulations on the interplay of noise and neuronal excitation, he started in the field of Systems Biology as a PostDoc at the Center for Modelling and Simulation in the Biosciences, University of Heidelberg, and German Cancer Research Center. His primary focus was on the development and simulation of protein signaling pathway models and gene regulatory networks. In 2009 he became a Junior research fellow at the Freiburg Institute of Advanced Studies (FRIAS) at the University of Freiburg.

Together with Dr. Dr. Melanie Börries he established a joint dry- and wet-lab at the Center for Biosystems Analysis (ZBSA), wherein they combined experimental research on cell-cell communication with the development of appropriate multi-scale dynamic models to investigate the necessary and sufficient control points that lead to cell proliferation, differentiation, migration or death.

In 2013, they moved their lab to the German Cancer Consortium partner site Freiburg at the Institute of Molecular Medicine and Cell Research, developing analysis pipelines for the stratification, diagnosis and therapy prediction of cancer patients based on sequencing technology.

Since October 2016, Prof. Busch is a newly appointed member of the Lübeck Institute of Experimental Dermatology and Member of the Excellence Cluster “Inflammation at Interfaces”, carrying over his Systems Biology approaches to study autoimmune diseases.

Further Academic Positions and Responsibilities:

• PI Medical Systems Biology
• Founding Member of the Center for Research on Inflammation of the Skin (CRIS) in 2017
• Member of Clinician Scientist School Lübeck
• Member of the University Cancer Center Schleswig-Holstein (UCCSH)
• Member of the Senatsausschuss der Sektion Medizin (SAM) and Senate of the University of Lübeck
• Member of the Stukturkommission of the University of Lübeck
• Member of the Steering Board of the Excellence Cluster “Inflammation at Interfaces”
• Member of the AG Bioinformatik of the DNPM Initiative
• Head of the Sharjah-Lübeck Dual Degree Program (w. Prof. Dr. J. Hundt)