Research Output per year
Research Output per year
Personal profile
Scientific Focus
The genome size of RNA viruses is usually restricted by the low fidelity of the RNA synthesis process. Interestingly, members of the order Nidovirales feature large RNA genomes that suggest a proof-reading activity by a 3’-5’ exoribonuclease (ExoN). We aim to structurally and functionally characterize ExoN proteins from different Nidovirus subfamilies such as Coronaviridae and Tobaniviridae to gain detailed insights into the role that ExoN plays in viral RNA replication fidelity.
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Collaborations and top research areas from the last five years
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Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins
Pomplun, S., Sippel, C., Hähle, A., Tay, D., Shima, K., Klages, A., Ünal, C. M., Rieß, B., Toh, H. T., Hansen, G., Yoon, H. S., Bracher, A., Preiser, P., Rupp, J., Steinert, M. & Hausch, F., 26.04.2018, In: Journal of Medicinal Chemistry. 61, 8, p. 3660-3673 14 p.Research output: Journal Articles › Journal articles › Research › peer-review
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Crystal structure of zika virus ns2b-ns3 protease in complex with a boronate inhibitor
Lei, J., Hansen, G., Nitsche, C., Klein, C. D., Zhang, L. & Hilgenfeld, R., 29.07.2016, In: Science. 353, 6298, p. 503-505 3 p.Research output: Journal Articles › Journal articles › Research › peer-review
59 Citations (Scopus) -
Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis
Li, Q., Jansen, H., Hansen, G., Nurjadi, D., Herrmann, J., Stadler, M., Brönstrup, M., Müller, R., He, C., Graspeuntner, S., Rupp, J. & Shima, K., 05.2024, In: International Journal of Antimicrobial Agents. 63, 5, p. 107132 107132.Research output: Journal Articles › Journal articles › Research › peer-review
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Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of Concern
Odak, I., Schultze-Florey, C. R., Hammerschmidt, S. I., Ritter, C., Willenzon, S., Friedrichsen, M., Ravens, I., Sikora, R., Bayir, L. M., Gutierrez Jauregui, R., Bernhardt, G., Stankov, M. V., Cossmann, A., Hansen, G., Krey, T., Cornberg, M., Koenecke, C., Behrens, G. M. N., Bošnjak, B. & Förster, R., 14.03.2022, In: Frontiers in Immunology. 13, 863039.Research output: Journal Articles › Journal articles › Research › peer-review
8 Citations (Scopus) -
Production, crystallization and X-ray diffraction analysis of the protease CT441 from Chlamydia trachomatis
Kohlmann, F., Shima, K., Rupp, J., Solbach, W., Hilgenfeld, R. & Hansen, G., 01.01.2015, In: Acta Crystallographica Section:F Structural Biology Communications. 71, p. 1454-1458 5 p.Research output: Journal Articles › Journal articles › Research › peer-review
Projects
- 1 Finished
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The tail-specific protease (Tsp) of Chlamydiae spp.: Mechanistic and structural characterization of its interactions with host-cell proteins
Hansen, G. (Principal Investigator (PI))
01.02.14 → 31.01.18
Project: DFG Projects › DFG Individual Projects