Institute of Molecular Medicine

Research output

Research Output per year 1986 1991 1993 1997 2005 2006 2008 2021

• 6347 Citations
• 157 Journal articles
• 13 Scientific review articles
• 4 Chapter
• 4 Conference contribution
• 11 More
  • 4 Editorial
  • 3 Comments/Debates
  • 2 Short survey
  • 1 Conference Papers
  • 1 Patents

Research Output per year

Research Output per year

Search results

• 2021

  Circular versus linear RNA topology: different modes of RNA-RNA interactions in vitro and in human cells

  Petkovic, S., Graff, S., Feller, N., Berghaus, J., Ruppert, V.-P., Dülfer, J. & Sczakiel, G., 12.11.2021, In: RNA Biology. 18, sup2, p. 674-683 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA 100%
  • RNA Topology 100%
  • MicroRNA 55%
  • Mammalia 11%
  • Species 11%

• Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection

  Dubois, J., Rueger, J., Haubold, B., Far, R. K. K. & Sczakiel, G., 11.05.2021, In: Oncotarget. 12, 10, p. 1011-1023 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene Expression Profiling 100%
  • RNA 100%
  • Quantitative Reverse Transcription Polymerase Chain Reaction 100%
  • Bladder Cancer 100%
  • Transmembrane Protein 16%
• 2020

  Oncoprotein 18 is necessary for malignant cell proliferation in bladder cancer cells and serves as a G3-specific non-invasive diagnostic marker candidate in urinary RNA

  Hanke, M., Dubois, J., Kausch, I., Petkovic, S. & Sczakiel, G., 07.2020, In: PLoS ONE. 15, 7, e0229193.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cell Proliferation 100%
  • RNA 100%
  • Bladder Cancer 100%
  • Gene 50%
  • Programmed Cell Death 50%
• 2017

  Analysis of AgoshRNA maturation and loading into Ago2

  Harwig, A., Kruize, Z., Yang, Z., Restle, T. & Berkhout, B., 01.08.2017, In: PLoS ONE. 12, 8, e0183269.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Processing 100%
  • Small Hairpin RNA 50%
  • Contrast 25%
  • RNA 25%
  • MicroRNA 25%
  1 Citation (Scopus)

• Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein

  Willkomm, S., Oellig, C. A., Zander, A., Restle, T., Keegan, R., Grohmann, D. & Schneider, S., 20.03.2017, In: Nature Microbiology. 2, 17035.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Enzyme 20%
  • Mutant 20%
  • Nucleotide 20%
  • Hinge Region 20%
  9 Citations (Scopus)
• 2016

  Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease

  Gupta, Y., Möller, S., Witte, M., Belheouane, M., Sezin, T., Hirose, M., Vorobyev, A., Niesar, F., Bischof, J., Ludwig, R. J., Zillikens, D., Sadik, C. D., Restle, T., Häsler, R., Baines, J. F. & Ibrahim, S. M., 16.02.2016, In: BMC Genomics. 17, 1, 112.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Mouse Model 100%
  • MicroRNA 100%
  • Coding 40%
  • Liver 20%
  • Inflammation 20%
  1 Citation (Scopus)

• FRET-based assay to screen inhibitors of HIV-1 reverse transcriptase and nucleocapsid protein

  Sharma, K. K., Przybilla, F., Restle, T., Godet, J. & Mély, Y., 05.05.2016, In: Nucleic Acids Research. 44, 8, p. e74

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein 100%
  • Energy Transfer 100%
  • Polymerization 50%
  • HIV 28%
  • RNA 25%
  4 Citations (Scopus)

• Lipophilic 2′-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery

  Biscans, A., Bertrand, J. R., Dubois, J., Rüger, J., Vasseur, J. J., Sczakiel, G., Dupouy, C. & Debart, F., 03.11.2016, In: Chembiochem. 17, 21, p. 2054-2062 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Nuclease 100%
  • RNA Synthesis 100%
  • Small Interfering RNA 100%
  • Ester 100%
  • RNA 100%
  2 Citations (Scopus)

• Mechanistic insights into archaeal and human argonaute substrate binding and cleavage properties

  Willkomm, S., Zander, A., Grohmann, D. & Restle, T., 01.10.2016, In: PLoS ONE. 11, 10, 164695.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA 37%
  4 Citations (Scopus)

• Recombinant hTRBP and hPACT modulate hAgo2-Catalyzed siRNA-mediated target RNA cleavage in vitro

  Willkomm, S., Deerberg, A., Heidemann, J., Flügge, F., Meine, J., Hu, R., Kretschmer-Kazemi Far, R. & Restle, T., 01.01.2016, In: PLoS ONE. 11, 1, e0146814.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Small Interfering RNA 100%
  • RNA-binding Protein 100%
  • Protein 37%
  • Mutant 25%
  • Binding Study 12%
  1 Citation (Scopus)
• 2015

  Novel insights into guide RNA 5ʹ-Nucleoside/Tide binding by human argonaute 2

  Kalia, M., Willkomm, S., Claussen, J. C., Restle, T. & Bonvin, A. M. J. J., 24.12.2015, In: International Journal of Molecular Sciences. 17, 1

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein 66%
  • Motion 16%
  • N-Terminus 16%
  • Complex Formation 16%
  • Non-Coding RNA 16%

• Reverse Transcriptase in Action: FRET-Based Assay for Monitoring Flipping and Polymerase Activity in Real Time

  Sharma, K. K., Przybilla, F., Restle, T., Boudier, C., Godet, J. & Mély, Y., 04.08.2015, In: Analytical Chemistry. 87, 15, p. 7690-7697 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Energy Transfer 100%
  • Polymerase 100%
  • Fluorescence Resonance Energy Transfer 100%
  • Ribonucleic Acid 50%
  • Inhibitor 33%
  5 Citations (Scopus)

• RNA circularization strategies in vivo and in vitro

  Petkovic, S. & Müller, S., 27.02.2015, In: Nucleic Acids Research. 43, 4, p. 2454-2465 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Life 100%
  • Transfer RNA 100%
  • Bacterium 100%
  • Biological Functions 100%
  • Eukaryote 100%
  50 Citations (Scopus)

• RNAi revised - Target mRNA-dependent enhancement of gene silencing

  Dornseifer, S., Willkomm, S., Far, R. K. K., Liebschwager, J., Beltsiou, F., Frank, K., Laufer, S. D., Martinetz, T., Sczakiel, G., Claussen, J. C. & Restle, T., 01.01.2015, In: Nucleic Acids Research. 43, 22, p. 10623-10632 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • In Vitro 100%
  • RNA 100%
  • Therapeutics 50%
  • Cells 50%
  • Nucleic Acid 50%
  6 Citations (Scopus)

• Sequence-controlled RNA self-processing: Computational design, biochemical analysis, and visualization by AFM

  Petkovic, S., Badelt, S., Block, S., Flamm, C., Delcea, M., Hofacker, I. & Müller, S., 01.01.2015, In: RNA. 21, 7, p. 1249-1260 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Analytical Method 100%
  • Ribonucleic Acid 100%
  • Atomic Force Microscopy 100%
  • Processing 100%
  • RNA 100%
  5 Citations (Scopus)
• 2014

  Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

  Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., Assimes, T. L., Kaiser, F. J., Perisic, L., Hedin, U., Maegdefessel, L., Schunkert, H., Erdmann, J., Quertermous, T. & Sczakiel, G., 01.01.2014, In: PLoS Genetics. 10, 3, e1004263.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Allele 100%
  • Regulatory Mechanism 100%
  • MicroRNA 100%
  • Coronary Artery 80%
  • Smooth Muscle Cell 60%
  37 Citations (Scopus)

• Direct synthesis of partially modified 2'-O-pivaloyloxymethyl RNAs by a base-labile protecting group strategy and their potential for prodrug-based gene-silencing applications

  Biscans, A., Bos, M., Martin, A. R., Ader, N., Sczakiel, G., Vasseur, J. J., Dupouy, C. & Debart, F., 24.10.2014, In: Chembiochem. 15, 18, p. 2674-2679 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Synthesis 100%
  • RNA 100%
  • Prodrug 100%
  • Nuclease 50%
  • Phosphate 25%
  5 Citations (Scopus)

• Inclusion of targeted therapies in the standard of care for metastatic colorectal cancer patients in a German cancer center: the more the better?!

  Moehler, M., Thomaidis, T., Zeifri, C., Barhoom, T., Marquardt, J., Ploch, P., Schattenberg, J., Maderer, A., Schimanski, C. C., Weinmann, A., Woerns, M. A., Kranich, A. L., Warnecke, J. M. & Galle, P. R., 03.2014, In: Journal of Cancer Research and Clinical Oncology. 141, 3, p. 515-522 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Patient 100%
  • Epidermal Growth Factor 66%
  • Anti-Epidermal Growth Factor Receptor 37%
  • Second-Line Chemotherapy 16%
  • First-Line Chemotherapy 16%
  8 Citations (Scopus)

• Prognostic significance and relationship of worst lead residual ST segment elevation with myocardial damage assessed by cardiovascular MRI in myocardial infarction

  Rommel, K. P., Baum, A., Mende, M., Desch, S., Gutberlet, M., Schuler, G., Thiele, H. & Eitel, I., 08.2014, In: Heart. 100, 16, p. 1257-1263 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cardiac Magnetic Resonance Imaging 100%
  • Heart Muscle Injury 100%
  • Heart Infarction 100%
  • Infarction 66%
  • Patient 55%
  8 Citations (Scopus)

• PtRNApred: Computational identification and classification of post-transcriptional RNA

  Gupta, Y., Witte, M., Möller, S., Ludwig, R. J., Restle, T., Zillikens, D. & Ibrahim, S. M., 16.12.2014, In: Nucleic Acids Research. 42, 22, e167.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA 100%
  • Non-Coding RNA 42%
  • Screening 14%
  • Regulatory Mechanism 14%
  • MicroRNA 14%
  1 Citation (Scopus)
• 2013

  A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural Switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

  Lyonnais, S., Gorelick, R. J., Heniche-Boukhalfa, F., Bouaziz, S., Parissi, V., Mouscadet, J. F., Restle, T., Gatell, J. M., Le Cam, E. & Mirambeau, G., 01.01.2013, In: Virus Research. 171, 2, p. 287-303 17 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein 100%
  • RNA 100%
  • Viral Protein 100%
  • Human Immunodeficiency Virus 1 80%
  • Synthesis 40%
  15 Citations (Scopus)

• Computational identification of biologically functional non-hairpin GC-helices in human Argonaute mRNA

  Dornseifer, S. & Sczakiel, G., 10.04.2013, In: BMC Bioinformatics. 14, 8 p., 122.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Messenger RNA 100%
  • RNA 100%
  • Length 25%
  • Gene 12%
  • Nucleotide 12%
  1 Citation (Scopus)

• Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein

  Deerberg, A., Willkomm, S. & Restle, T., 29.10.2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 44, p. 17850-17855 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein 100%
  • RNA 100%
  • Small Interfering RNA 100%
  • Steady State 50%
  • Conformational Change 25%
  29 Citations (Scopus)

• Photocoagulation in rabbits: Optical coherence tomographic lesion classification, wound healing reaction, and retinal temperatures

  Koinzer, S., Hesse, C., Caliebe, A., Saeger, M., Baade, A., Schlott, K., Brinkmann, R. & Roider, J., 09.2013, In: Lasers in Surgery and Medicine. 45, 7, p. 427-436 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Wound Healing 100%
  • Lesion 100%
  • Coherence 100%
  • Laser Coagulation 100%
  • Leporidae 100%
  10 Citations (Scopus)
• 2012

  A toolkit and benchmark study for FRET-restrained high-precision structural modeling

  Kalinin, S., Peulen, T., Sindbert, S., Rothwell, P. J., Berger, S., Restle, T., Goody, R. S., Gohlke, H. & Seidel, C. A. M., 01.12.2012, In: Nature Methods. 9, 12, p. 1218-1225 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Energy Transfer 100%
  • Investigation 100%
  • Screening 25%
  • X Ray 25%
  • Biomolecule 25%
  153 Citations (Scopus)

• Functional binding of hexanucleotides to 3C protease of hepatitis A virus

  Blaum, B. S., Wünsche, W., Benie, A. J., Kusov, Y., Peters, H., Gauss-Müller, V., Peters, T. & Sczakiel, G., 01.04.2012, In: Nucleic Acids Research. 40, 7, p. 3042-3055 14 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protease 100%
  • Binding Site 75%
  • Oligonucleotide 50%
  • Protein 25%
  • C-Terminus 25%
  5 Citations (Scopus)

• MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3′-UTR via altered RNA structure

  Haas, U., Sczakiel, G. & Laufer, S. D., 01.01.2012, In: RNA Biology. 9, 6, p. 924-937 14 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Single-Nucleotide Polymorphism 100%
  • Regulatory Mechanism 100%
  • MicroRNA 100%
  • Protein 10%
  • RNA 10%
  60 Citations (Scopus)
• 2011

  Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells

  Detzer, A., Engel, C., Wünsche, W. & Sczakiel, G., 01.04.2011, In: Nucleic Acids Research. 39, 7, p. 2727-2741 15 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Human Cell 100%
  • Cell Stress 100%
  • Stress 75%
  • Genetic Transfection 25%
  • Transfection 25%
  30 Citations (Scopus)

• Specific recognition of proteins by array-bound hexanucleotides

  Mescalchin, A., Wünsche, W. & Sczakiel, G., 01.02.2011, In: Angewandte Chemie - International Edition. 50, 5, p. 1052-1054 3 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein 100%
  • Density 50%
  • Human immunodeficiency virus 50%
  • Human Immunodeficiency Virus 1 50%
  4 Citations (Scopus)

• Synthesis and preliminary evaluation of pro-RNA 2′- O -masked with biolabile pivaloyloxymethyl groups in an RNA interference assay

  Lavergne, T., Baraguey, C., Dupouy, C., Parey, N., Wuensche, W., Sczakiel, G., Vasseur, J. J. & Debart, F., 15.07.2011, In: Journal of Organic Chemistry. 76, 14, p. 5719-5731 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Small Interfering RNA 100%
  • Prodrug 66%
  • Drug 33%
  • Cell Culture 33%
  23 Citations (Scopus)
• 2010

  Antisense tools for functional studies of human Argonaute proteins

  Mescalchin, A., Detzer, A., Weirauch, U., Hahnel, M. J., Engel, C. & Sczakiel, G., 01.12.2010, In: RNA. 16, 12, p. 2529-2536 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Antisense 100%
  • Small Interfering RNA 80%
  • Oligonucleotide 80%
  • Antisense Oligonucleotide 80%
  • MicroRNA 60%
  8 Citations (Scopus)

• A robust methodology to study urine microRNA as tumor marker: MicroRNA-126 and microRNA-182 are related to urinary bladder cancer

  Hanke, M., Hoefig, K., Merz, H., Feller, A. C., Kausch, I., Jocham, D., Warnecke, J. M. & Sczakiel, G., 01.11.2010, In: Urologic Oncology: Seminars and Original Investigations. 28, 6, p. 655-661 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA 100%
  • microRNA 100%
  • Urine 100%
  • MicroRNA 100%
  • Patient 71%
  375 Citations (Scopus)
• 2009

  Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide

  Detzer, A., Overhoff, M., Wünsche, W., Rompf, M., Turner, J. J., Ivanova, G. D., Gait, M. J. & Sczakiel, G., 01.04.2009, In: RNA. 15, 4, p. 627-636 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Small Interfering RNA 100%
  • RNA 100%
  • Intracellular Trafficking 15%
  • Gene 7%
  • Contrast 7%
  35 Citations (Scopus)

• Noncovalent peptide-mediated delivery of chemically modified steric block oligonucleotides promotes splice correction: Quantitative analysis of uptake and biological effect

  Laufer, S. D., Recke, A. L., Veldhoen, S., Trampe, A. & Restle, T., 01.03.2009, In: Oligonucleotides. 19, 1, p. 63-80 18 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Quantitative Analysis 100%
  • Quantitative Technique 100%
  • Oligonucleotide 100%
  • Peptides 100%
  • Reporter Gene 60%
  8 Citations (Scopus)

• RNAi2009 - Fourth international conference and exhibition

  Sczakiel, G., 05.2009, In: IDrugs. 12, 5, p. 278-281 4 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Drug 100%
  • Small Interfering RNA 100%
• 2008

  Breast cancer diagnostics based on extracellular DNA and RNA circulating in blood

  Rykova, E. Y., Skvortsova, T. E., Hoffmann, A. L., Tamkovich, S. N., Starikov, A. V., Bryzgunova, O. E., Permjakova, V. I., Warnecke, J. M., Sczakiel, G., Vlassov, V. V. & Laktionov, P. P., 01.01.2008, In: Biomeditsinskaya Khimiya. 54, 1, p. 94-103 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Patient 100%
  • Blood 100%
  • Breast Cancer 100%
  • Cancer Diagnostics 100%
  • RNA 100%
  13 Citations (Scopus)

• HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates

  Grohmann, D., Godet, J., Mély, Y., Darlix, J. L. & Restle, T., 18.11.2008, In: Biochemistry. 47, 46, p. 12230-12240 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Human Immunodeficiency Virus 1 100%
  • Nucleotide 42%
  • Protein 14%
  • RNA 14%
  • Human immunodeficiency virus 14%
  29 Citations (Scopus)

• Opposed steric constraints in human DNA polymerase β and E. coli DNA polymerase I

  Di Pasquale, F., Fischer, D., Grohmann, D., Restle, T., Geyer, A. & Marx, A., 13.08.2008, In: Journal of the American Chemical Society. 130, 32, p. 10748-10757 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • DNA Polymerase 100%
  • Nucleotide 62%
  • DNA 37%
  • Active Site 25%
  • Enzyme 12%
  16 Citations (Scopus)

• Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization

  Grohmann, D., Corradi, V., Elbasyouny, M., Baude, A., Horenkamp, F., Laufer, S. D., Manetti, F., Botta, M. & Restle, T., 14.04.2008, In: Chembiochem. 9, 6, p. 916-922 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Small Molecule 100%
  • Dimerization 100%
  • Human Immunodeficiency Virus 1 100%
  • Enzyme 28%
  • Database 14%
  22 Citations (Scopus)

• Varied active-site constraints in the Klenow fragment of E. coli DNA polymerase I and the lesion-bypass Dbh DNA polymerase

  Cramer, J., Rangam, G., Marx, A. & Restle, T., 23.05.2008, In: Chembiochem. 9, 8, p. 1243-1250 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Active Site 100%
  • Nucleotide 100%
  • Escherichia coli 100%
  • Enzyme 80%
  • Reduction (Chemistry) 40%
  6 Citations (Scopus)
• 2007

  A hexanucleotide selected for increased cellular uptake in cis contains a highly active CpG-motif in human B cells and primary peripheral blood mononuclear cells

  Mende, M., Hopert, A., Wünsche, W., Overhoff, M., Detzer, A., Börngen, K., Schlenke, P., Kirchner, H. & Sczakiel, G., 01.02.2007, In: Immunology. 120, 2, p. 261-272 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • B Cell 100%
  • Guanosine Phosphate 100%
  • Therapeutics 10%
  • Stimulation 10%
  • Mammalian Cell 10%
  4 Citations (Scopus)

• Aptamer Displacement Identifies Alternative Small-Molecule Target Sites that Escape Viral Resistance

  Yamazaki, S., Tan, L., Mayer, G., Hartig, J. S., Song, J. N., Reuter, S., Restle, T., Laufer, S. D., Grohmann, D., Kräusslich, H. G., Bajorath, J. & Famulok, M., 30.07.2007, In: Chemistry and Biology. 14, 7, p. 804-812 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Aptamer 100%
  • Small Molecule 100%
  • Protein 40%
  • Human Immunodeficiency Virus 1 40%
  • Wild Type 20%
  48 Citations (Scopus)

• HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner

  Mirambeau, G., Lyonnais, S., Coulaud, D., Hameau, L., Lafosse, S., Jeusset, J., Borde, I., Reboud-Ravaux, M., Restle, T., Gorelick, R. J. & Le Cam, E., 22.08.2007, In: PLoS ONE. 2, 8, e669.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • HIV-1 Protease 100%
  • Human Immunodeficiency Virus 1 100%
  • Protein 44%
  • Protease 22%
  • Synthesis 11%
  36 Citations (Scopus)
• 2006

  Analysis of RNase P protein (rnpA) expression in Bacillus subtilis utilizing strains with suppressible rnpA expression

  Gößringer, M., Far, R. K. K. & Hartmann, R. K., 01.10.2006, In: Journal of Bacteriology. 188, 19, p. 6816-6823 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein 100%
  • Bacilli 100%
  • Bacillus subtilis 100%
  • Gene 25%
  • RNA 25%
  33 Citations (Scopus)

• Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BΔ21, HC-J4)

  Cramer, J., Jaeger, J. & Restle, T., 21.03.2006, In: Biochemistry. 45, 11, p. 3610-3619 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA Polymerase 100%
  • Nucleotide 100%
  • Steady State 100%
  • Oligomerization 80%
  • Protein 40%
  22 Citations (Scopus)

• Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: Quantitative analysis of uptake and biological effect

  Veldhoen, S., Laufer, S. D., Trampe, A. & Restle, T., 12.2006, In: Nucleic Acids Research. 34, 22, p. 6561-6573 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Quantitative Technique 100%
  • Small Interfering RNA 100%
  • Cell-Penetrating Peptide 100%
  • RNA 100%
  • Transfection 42%
  157 Citations (Scopus)

• Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts

  Wu, J., Reinhardt, D. P., Batmunkh, C., Lindenmaier, W., Far, R. K. K., Notbohm, H., Hunzelmann, N. & Brinckmann, J., 01.11.2006, In: Experimental Cell Research. 312, 18, p. 3485-3494 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Collagen 100%
  • Lysyl Hydroxylase 100%
  • Cross-Link 83%
  • Messenger RNA 50%
  • Protein 33%
  20 Citations (Scopus)

• Molecular alterations after Polo-like kinase 1 mRNA suppression versus pharmacologic inhibition in cancer cells

  Schmidt, M., Hofmann, H. P., Sanders, K., Sczakiel, G., Beckers, T. L. & Gekeler, V., 01.04.2006, In: Molecular Cancer Therapeutics. 5, 4, p. 809-817 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cancer Cell 100%
  • Polo-Like Kinase 1 100%
  • Cells 50%
  • Apoptosis 30%
  • Marker 20%
  16 Citations (Scopus)

• Specific binding of a hexanucleotide to HIV-1 reverse transcriptase: A novel class of bioactive molecules

  Mescalchin, A., Wünsche, W., Laufer, S. D., Grohmann, D., Restle, T. & Sczakiel, G., 01.11.2006, In: Nucleic Acids Research. 34, 19, p. 5631-5637 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Human Immunodeficiency Virus 1 100%
  • Cross-Link 33%
  • Length 33%
  • Aptamer 33%
  • Oligonucleotide 33%
  7 Citations (Scopus)

• The large form of ADAR 1 is responsible for enhanced hepatitis delta virus RNA editing in interferon-α-stimulated host cells

  Hartwig, D., Schütte, C., Warnecke, J., Dorn, I., Hennig, H., Kirchner, H. & Schlenke, P., 03.2006, In: Journal of Viral Hepatitis. 13, 3, p. 150-157 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Host Cell 100%
  • Interferon 100%
  • RNA Editing 100%
  • Adenosine Deaminase 100%
  • Hepatitis delta virus 100%
  33 Citations (Scopus)