Institute of Molecular Medicine

Research output

Research output per year 1986 1991 1993 1997 2005 2006 2008 2021

• 6347 Citations
• 157 Journal articles
• 13 Scientific review articles
• 4 Chapter
• 4 Conference contribution
• 11 More
  • 4 Editorial
  • 3 Comments/Debates
  • 2 Short survey
  • 1 Conference Papers
  • 1 Patents

Research output per year

Research output per year

Search results

• 2021

  Circular versus linear RNA topology: different modes of RNA-RNA interactions in vitro and in human cells

  Petkovic, S., Graff, S., Feller, N., Berghaus, J., Ruppert, V-P., Dülfer, J. & Sczakiel, G., 12.11.2021, In: RNA Biology. 18, sup2, p. 674-683 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Circular RNAs 100%
  • RNA 71%
  • MicroRNAs 61%
  • In Vitro Techniques 44%
  • Urinary Bladder Neoplasms 28%

• Genotype–Phenotype Relations for Isolated Dystonia Genes: MDSGene Systematic Review

  Lange, L. M., Junker, J., Loens, S., Baumann, H., Olschewski, L., Schaake, S., Madoev, H., Petkovic, S., Kuhnke, N., Kasten, M., Westenberger, A., Domingo, A., Marras, C., König, I. R., Camargos, S., Ozelius, L. J., Klein, C. & Lohmann, K., 2021, In: Movement Disorders.

  Research output: Journal Articles › Scientific review articles › Research

  • Dystonia 100%
  • Systematic Reviews 62%
  • Mutation 47%
  • Genes 34%
  • Neck 14%

• Genotype–Phenotype Relations for the Atypical Parkinsonism Genes: MDSGene Systematic Review

  MDS-endorsed PSP Study Group, 07.2021, In: Movement Disorders. 36, 7, p. 1499-1510 12 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Parkinsonian Disorders 100%
  • Systematic Reviews 67%
  • Age of Onset 57%
  • Levodopa 50%
  • Genetic Databases 39%

• Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection

  Dubois, J., Rueger, J., Haubold, B., Far, R. K. K. & Sczakiel, G., 11.05.2021, In: Oncotarget. 12, 10, p. 1011-1023 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene Expression Profiling 100%
  • Tumor Biomarkers 94%
  • Urinary Bladder Neoplasms 92%
  • Urine 68%
  • RNA 67%
• 2020

  Oncoprotein 18 is necessary for malignant cell proliferation in bladder cancer cells and serves as a G3-specific non-invasive diagnostic marker candidate in urinary RNA

  Hanke, M., Dubois, J., Kausch, I., Petkovic, S. & Sczakiel, G., 07.2020, In: PLoS ONE. 15, 7, e0229193.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Stathmin 100%
  • Urinary Bladder Neoplasms 62%
  • RNA 44%
  • Cell Proliferation 42%
  • Urine 20%
• 2019

  Antisense Arzneimittel gegen das humane interzelluläre Adhäsionsmolekül (ICAM-1)

  Sczakiel, G. & Kretschmer-Kazemi Far, R., 25.01.2019, Patent No. EP3914710A1, Priority date 25.01.2019, Priority No. EP19153666.3

  Research output: Patents
• 2017

  Analysis of AgoshRNA maturation and loading into Ago2

  Harwig, A., Kruize, Z., Yang, Z., Restle, T. & Berkhout, B., 01.08.2017, In: PLoS ONE. 12, 8, e0183269.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • poly(A)-specific ribonuclease 100%
  • Small Interfering RNA 87%
  • RNA Interference 50%
  • High-Throughput Nucleotide Sequencing 50%
  • MicroRNAs 43%
  1 Citation (Scopus)

• Antibiotic resistance: Blocking tetracycline destruction

  Petkovic, S. & Hinrichs, W., 01.07.2017, In: Nature Chemical Biology. 13, 7, p. 694-695 2 p.

  Research output: Journal Articles › Short survey › peer-review

  • Tetracycline 100%
  • Antimicrobial Agent 61%
  • Resistance 55%

• Kinetic analysis of target RNA binding and slicing by human Argonaute 2 protein

  Willkomm, S. & Restle, T., 01.01.2017, Methods in Molecular Biology. Humana Press Inc., p. 277-290 14 p. (Methods in Molecular Biology; vol. 1517).

  Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

  • human AGO2 protein 100%
  • Kinetics 32%
  • RNA 31%
  • RNA Interference 28%
  • Gene Expression 27%

• Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein

  Willkomm, S., Oellig, C. A., Zander, A., Restle, T., Keegan, R., Grohmann, D. & Schneider, S., 20.03.2017, In: Nature Microbiology. 2, 17035.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Archaeal DNA 100%
  • Argonaute Proteins 84%
  • DNA 30%
  • Methanocaldococcus 30%
  • Eukaryota 18%
  9 Citations (Scopus)
• 2016

  Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease

  Gupta, Y., Möller, S., Witte, M., Belheouane, M., Sezin, T., Hirose, M., Vorobyev, A., Niesar, F., Bischof, J., Ludwig, R. J., Zillikens, D., Sadik, C. D., Restle, T., Häsler, R., Baines, J. F. & Ibrahim, S. M., 16.02.2016, In: BMC Genomics. 17, 1, 112.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Autoimmune Diseases 100%
  • MicroRNAs 97%
  • Skin 63%
  • Genes 12%
  • Chromosomes, Human, Pair 6 10%
  1 Citation (Scopus)

• FRET-based assay to screen inhibitors of HIV-1 reverse transcriptase and nucleocapsid protein

  Sharma, K. K., Przybilla, F., Restle, T., Godet, J. & Mély, Y., 05.05.2016, In: Nucleic Acids Research. 44, 8, p. e74

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Nucleocapsid Proteins 100%
  • Human immunodeficiency virus 1 reverse transcriptase 99%
  • Energy Transfer 94%
  • RNA-Directed DNA Polymerase 84%
  • Polymerization 49%
  4 Citations (Scopus)

• Lipophilic 2′-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery

  Biscans, A., Bertrand, J. R., Dubois, J., Rüger, J., Vasseur, J. J., Sczakiel, G., Dupouy, C. & Debart, F., 03.11.2016, In: Chembiochem. 17, 21, p. 2054-2062 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Acetals 100%
  • Esters 60%
  • Small Interfering RNA 49%
  • Hot Temperature 45%
  • RNA 40%
  2 Citations (Scopus)

• Mechanistic insights into archaeal and human argonaute substrate binding and cleavage properties

  Willkomm, S., Zander, A., Grohmann, D. & Restle, T., 01.10.2016, In: PLoS ONE. 11, 10, 164695.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • DNA 100%
  • Argonaute Proteins 92%
  • RNA 82%
  • Guide RNA 82%
  • Nucleic Acids 58%
  4 Citations (Scopus)

• Recombinant hTRBP and hPACT modulate hAgo2-Catalyzed siRNA-mediated target RNA cleavage in vitro

  Willkomm, S., Deerberg, A., Heidemann, J., Flügge, F., Meine, J., Hu, R., Kretschmer-Kazemi Far, R. & Restle, T., 01.01.2016, In: PLoS ONE. 11, 1, e0146814.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • trans-activation responsive RNA-binding protein 100%
  • RNA Cleavage 78%
  • Small Interfering RNA 44%
  • In Vitro Techniques 23%
  • RNA Interference 21%
  1 Citation (Scopus)
• 2015

  Conformational dynamics of ago-mediated silencing processes

  Willkomm, S. & Restle, T., 01.07.2015, In: International Journal of Molecular Sciences. 16, 7, p. 14769-14785 17 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Argonaute Proteins 100%
  • Nucleic Acids 15%
  7 Citations (Scopus)

• Novel insights into guide RNA 5ʹ-Nucleoside/Tide binding by human argonaute 2

  Kalia, M., Willkomm, S., Claussen, J. C., Restle, T. & Bonvin, A. M. J. J., 24.12.2015, In: International Journal of Molecular Sciences. 17, 1

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Guide RNA 100%
  • Nucleosides 76%
  • human AGO2 protein 40%
  • Small Untranslated RNA 21%
  • Molecular Dynamics Simulation 20%

• Reverse Transcriptase in Action: FRET-Based Assay for Monitoring Flipping and Polymerase Activity in Real Time

  Sharma, K. K., Przybilla, F., Restle, T., Boudier, C., Godet, J. & Mély, Y., 04.08.2015, In: Analytical Chemistry. 87, 15, p. 7690-7697 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Energy Transfer 100%
  • RNA-Directed DNA Polymerase 89%
  • Reverse Transcriptase Inhibitors 73%
  • Fluorescence 24%
  • Multifunctional Enzymes 23%
  5 Citations (Scopus)

• RNA circularization strategies in vivo and in vitro

  Petkovic, S. & Müller, S., 27.02.2015, In: Nucleic Acids Research. 43, 4, p. 2454-2465 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Circular RNAs 100%
  • RNA 50%
  • In Vitro Techniques 32%
  • Viroids 24%
  • Exonucleases 19%
  50 Citations (Scopus)

• RNAi revised - Target mRNA-dependent enhancement of gene silencing

  Dornseifer, S., Willkomm, S., Far, R. K. K., Liebschwager, J., Beltsiou, F., Frank, K., Laufer, S. D., Martinetz, T., Sczakiel, G., Claussen, J. C. & Restle, T., 01.01.2015, In: Nucleic Acids Research. 43, 22, p. 10623-10632 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene Silencing 100%
  • RNA Interference 90%
  • Messenger RNA 53%
  • RNA 26%
  • Nucleic Acids 18%
  6 Citations (Scopus)

• Sequence-controlled RNA self-processing: Computational design, biochemical analysis, and visualization by AFM

  Petkovic, S., Badelt, S., Block, S., Flamm, C., Delcea, M., Hofacker, I. & Müller, S., 01.01.2015, In: RNA. 21, 7, p. 1249-1260 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Catalytic RNA 100%
  • hairpin ribozyme 54%
  • RNA 31%
  5 Citations (Scopus)
• 2014

  Consolidated numerical temperature/pressure modelling to assess the accuracy of optoacoustic temperature determination during retinal photocoagulation

  Baade, A., Schlott, K., Birngruber, R. & Brinkmann, R., 26.02.2014, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications. Jansen, E. D., J. Thomas, R., J. Wilmink, G. & L. Ibey, B. (eds.). SPIE, Vol. 8941. 11 p. 89410H. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8941).

  Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

  • irradiation 100%
  • profiles 84%
  • temperature 64%
  • elastic waves 60%
  • lasers 40%

• Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

  Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., Assimes, T. L., Kaiser, F. J., Perisic, L., Hedin, U., Maegdefessel, L., Schunkert, H., Erdmann, J., Quertermous, T. & Sczakiel, G., 01.01.2014, In: PLoS Genetics. 10, 3, e1004263.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Coronary Disease 100%
  • MicroRNAs 95%
  • Binding Sites 87%
  • Alleles 82%
  • Coronary Vessels 74%
  37 Citations (Scopus)

• Direct synthesis of partially modified 2'-O-pivaloyloxymethyl RNAs by a base-labile protecting group strategy and their potential for prodrug-based gene-silencing applications

  Biscans, A., Bos, M., Martin, A. R., Ader, N., Sczakiel, G., Vasseur, J. J., Dupouy, C. & Debart, F., 24.10.2014, In: Chembiochem. 15, 18, p. 2674-2679 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Prodrugs 100%
  • Gene Silencing 95%
  • Butylamines 86%
  • RNA Transport 68%
  • RNA 62%
  5 Citations (Scopus)

• Inclusion of targeted therapies in the standard of care for metastatic colorectal cancer patients in a German cancer center: the more the better?!

  Moehler, M., Thomaidis, T., Zeifri, C., Barhoom, T., Marquardt, J., Ploch, P., Schattenberg, J., Maderer, A., Schimanski, C. C., Weinmann, A., Woerns, M. A., Kranich, A. L., Warnecke, J. M. & Galle, P. R., 03.2014, In: Journal of Cancer Research and Clinical Oncology. 141, 3, p. 515-522 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Standard of Care 100%
  • Colorectal Neoplasms 82%
  • Survival 40%
  • ErbB Receptors 39%
  • Vascular Endothelial Growth Factor A 35%
  8 Citations (Scopus)

• Prognostic significance and relationship of worst lead residual ST segment elevation with myocardial damage assessed by cardiovascular MRI in myocardial infarction

  Rommel, K. P., Baum, A., Mende, M., Desch, S., Gutberlet, M., Schuler, G., Thiele, H. & Eitel, I., 08.2014, In: Heart. 100, 16, p. 1257-1263 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Lead 100%
  • Infarction 91%
  • Myocardial Infarction 79%
  • Percutaneous Coronary Intervention 65%
  • Magnetic Resonance Spectroscopy 55%
  8 Citations (Scopus)

• PtRNApred: Computational identification and classification of post-transcriptional RNA

  Gupta, Y., Witte, M., Möller, S., Ludwig, R. J., Restle, T., Zillikens, D. & Ibrahim, S. M., 16.12.2014, In: Nucleic Acids Research. 42, 22, e167.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Untranslated RNA 100%
  • Small Nucleolar RNA 85%
  • RNA 81%
  • Ribonuclease P 44%
  • telomerase RNA 43%
  1 Citation (Scopus)
• 2013

  A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural Switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

  Lyonnais, S., Gorelick, R. J., Heniche-Boukhalfa, F., Bouaziz, S., Parissi, V., Mouscadet, J. F., Restle, T., Gatell, J. M., Le Cam, E. & Mirambeau, G., 01.01.2013, In: Virus Research. 171, 2, p. 287-303 17 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Human immunodeficiency virus 1 reverse transcriptase 100%
  • Nucleocapsid 96%
  • Viral Genome 82%
  • Viral Proteins 77%
  • HIV-1 50%
  15 Citations (Scopus)

• Computational identification of biologically functional non-hairpin GC-helices in human Argonaute mRNA

  Dornseifer, S. & Sczakiel, G., 10.04.2013, In: BMC Bioinformatics. 14, 8 p., 122.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA 100%
  • Messenger RNA 82%
  • Base Pairing 36%
  • Renilla Luciferases 28%
  • RNA Folding 27%
  1 Citation (Scopus)

• Effect of the HIV-1 nucleocapsid protein on reverse transcriptase pause sites revealed by single molecule microscopy

  Jouonang, A., Przybilla, F., Godet, J., Sharma, K. K., Restle, T., De Rocquigny, H., Darlix, J. L., Kenfack, C., Didier, P. & Mély, Y., 22.02.2013, Proceedings Volume 8590, Single Molecule Spectroscopy and Superresolution Imaging VI. SPIE, Vol. 859009 . (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 859009).

  Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

  • Nucleocapsid Proteins 100%
  • Single Molecule Imaging 99%
  • RNA-Directed DNA Polymerase 84%
  • HIV-1 63%
  • Human immunodeficiency virus 1 NCP7 protein 24%

• Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein

  Deerberg, A., Willkomm, S. & Restle, T., 29.10.2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 44, p. 17850-17855 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • human AGO2 protein 100%
  • recombinant RNA 75%
  • Argonaute Proteins 46%
  • RNA Interference 43%
  • Small Interfering RNA 37%
  29 Citations (Scopus)

• Photocoagulation in rabbits: Optical coherence tomographic lesion classification, wound healing reaction, and retinal temperatures

  Koinzer, S., Hesse, C., Caliebe, A., Saeger, M., Baade, A., Schlott, K., Brinkmann, R. & Roider, J., 09.2013, In: Lasers in Surgery and Medicine. 45, 7, p. 427-436 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Light Coagulation 100%
  • Wound Healing 74%
  • Temperature 60%
  • Rabbits 60%
  • Lasers 19%
  10 Citations (Scopus)
• 2012

  A toolkit and benchmark study for FRET-restrained high-precision structural modeling

  Kalinin, S., Peulen, T., Sindbert, S., Rothwell, P. J., Berger, S., Restle, T., Goody, R. S., Gohlke, H. & Seidel, C. A. M., 01.12.2012, In: Nature Methods. 9, 12, p. 1218-1225 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Energy Transfer 100%
  • Benchmarking 82%
  • Coloring Agents 42%
  • Human immunodeficiency virus 1 reverse transcriptase 34%
  • DNA Primers 33%
  153 Citations (Scopus)

• "Chemie in unserer Zeit" in der Stadt der Wissenschaft 2012

  Translated title of the contribution: "Chemie in unserer Zeit" in the City of Science 2012Sczakiel, G., 08.2012, In: Chemie in Unserer Zeit. 46, 4, p. 199 1 p.

  Research output: Journal Articles › Editorial

• Functional binding of hexanucleotides to 3C protease of hepatitis A virus

  Blaum, B. S., Wünsche, W., Benie, A. J., Kusov, Y., Peters, H., Gauss-Müller, V., Peters, T. & Sczakiel, G., 01.04.2012, In: Nucleic Acids Research. 40, 7, p. 3042-3055 14 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • 3C proteases 100%
  • Binding Sites 47%
  • Viral RNA 45%
  • Oligonucleotides 43%
  • G-Quadruplexes 30%
  5 Citations (Scopus)

• MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3′-UTR via altered RNA structure

  Haas, U., Sczakiel, G. & Laufer, S. D., 01.01.2012, In: RNA Biology. 9, 6, p. 924-937 14 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene Expression Regulation 100%
  • 3' Untranslated Regions 96%
  • MicroRNAs 78%
  • Single Nucleotide Polymorphism 77%
  • RNA 64%
  60 Citations (Scopus)

• microRNAs in human diseases and viral infections

  Mescalchin, A. & Restle, T., 01.01.2012, From Nucleic Acids Sequences to Molecular Medicine. Springer Berlin Heidelberg, p. 525-551 27 p.

  Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

  • MicroRNAs 100%
  • Virus Diseases 87%
  • Polyomavirus 17%
  • DNA Viruses 16%
  • Small Untranslated RNA 16%

• Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase Activity

  Xiao, Y., Ma, Q., Restle, T., Shang, W., Svergun, D. I., Ponnusamy, R., Sczakiel, G. & Hilgenfeld, R., 15.04.2012, Journal of Virology. p. 4444-4454 11 p. (Journal of Virology; vol. 86).

  Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

  • Feline Coronavirus 100%
  • DNA-Directed RNA Polymerases 68%
  • His-His-His-His-His-His 65%
  • Severe Acute Respiratory Syndrome 59%
  • Coronavirus 58%
• 2011

  Accuracy of real-time optoacoustic temperature determination during retinal photocoagulation

  Baade, A., Schlott, K., Luft, S., Ptaszynski, L., Bever, M., Birngruber, R. & Brinkmann, R., 2011.

  Research output: Contribution to conference › Conference Papers › peer-review

  • temperature 100%
  • retina 86%
  • elastic waves 73%
  • laser beams 54%
  • deviation 53%

• Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells

  Detzer, A., Engel, C., Wünsche, W. & Sczakiel, G., 01.04.2011, In: Nucleic Acids Research. 39, 7, p. 2727-2741 15 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA Interference 100%
  • Phosphorothioate Oligonucleotides 40%
  • Heat-Shock Response 28%
  • Transfection 22%
  • RNA-Induced Silencing Complex 20%
  30 Citations (Scopus)

• Oligomeric nucleic acids as antivirals

  Mescalchin, A. & Restle, T., 01.02.2011, In: Molecules. 16, 2, p. 1271-1296 26 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Oligonucleotides 100%
  • Nucleic Acids 94%
  • Antiviral Agents 82%
  • Synthetic Drugs 66%
  • Antisense RNA 61%
  24 Citations (Scopus)

• Optoacoustic temperature determination and automatic coagulation control in rabbits

  Schlott, K., Koinzer, S., Ptaszynski, L., Luft, S., Baade, A., Bever, M., Roider, J., Birngruber, R. & Brinkmann, R., 16.02.2011, Ophthalmic Technologies XXI. Manns, F., Söderberg, P. G. & Ho, A. (eds.). SPIE, Vol. 7885. 8 p. 78850T. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 7885).

  Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

  • rabbits 100%
  • coagulation 99%
  • lasers 38%
  • lesions 35%
  • irradiation 34%

• Specific recognition of proteins by array-bound hexanucleotides

  Mescalchin, A., Wünsche, W. & Sczakiel, G., 01.02.2011, In: Angewandte Chemie - International Edition. 50, 5, p. 1052-1054 3 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • HIV-2 100%
  • Protein Array Analysis 97%
  • Lead 70%
  • HIV-1 67%
  • Pharmaceutical Preparations 32%
  4 Citations (Scopus)

• Synthesis and preliminary evaluation of pro-RNA 2′- O -masked with biolabile pivaloyloxymethyl groups in an RNA interference assay

  Lavergne, T., Baraguey, C., Dupouy, C., Parey, N., Wuensche, W., Sczakiel, G., Vasseur, J. J. & Debart, F., 15.07.2011, In: Journal of Organic Chemistry. 76, 14, p. 5719-5731 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RNA Interference 100%
  • RNA 72%
  • Small Interfering RNA 65%
  • Prodrugs 57%
  • Fluorides 57%
  23 Citations (Scopus)
• 2010

  Antisense tools for functional studies of human Argonaute proteins

  Mescalchin, A., Detzer, A., Weirauch, U., Hahnel, M. J., Engel, C. & Sczakiel, G., 01.12.2010, In: RNA. 16, 12, p. 2529-2536 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Argonaute Proteins 100%
  • Antisense Oligonucleotides 74%
  • Small Interfering RNA 53%
  • MicroRNAs 40%
  • RNA Interference 30%
  8 Citations (Scopus)

• A robust methodology to study urine microRNA as tumor marker: MicroRNA-126 and microRNA-182 are related to urinary bladder cancer

  Hanke, M., Hoefig, K., Merz, H., Feller, A. C., Kausch, I., Jocham, D., Warnecke, J. M. & Sczakiel, G., 01.11.2010, In: Urologic Oncology: Seminars and Original Investigations. 28, 6, p. 655-661 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Tumor Biomarkers 100%
  • Urinary Bladder Neoplasms 98%
  • MicroRNAs 86%
  • Urine 72%
  • RNA 62%
  375 Citations (Scopus)
• 2009

  Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide

  Detzer, A., Overhoff, M., Wünsche, W., Rompf, M., Turner, J. J., Ivanova, G. D., Gait, M. J. & Sczakiel, G., 01.04.2009, In: RNA. 15, 4, p. 627-636 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein Sorting Signals 100%
  • RNA Interference 88%
  • Small Interfering RNA 77%
  • Peptides 14%
  • Lamin Type A 10%
  35 Citations (Scopus)

• Noncovalent peptide-mediated delivery of chemically modified steric block oligonucleotides promotes splice correction: Quantitative analysis of uptake and biological effect

  Laufer, S. D., Recke, A. L., Veldhoen, S., Trampe, A. & Restle, T., 01.03.2009, In: Oligonucleotides. 19, 1, p. 63-80 18 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • locked nucleic acid 100%
  • Oligonucleotides 67%
  • Phosphorothioate Oligonucleotides 60%
  • Peptide Nucleic Acids 57%
  • Peptides 41%
  8 Citations (Scopus)

• Phosphorothioate-stimulated uptake of siRNA by mammalian cells: A novel route for delivery

  Detzer, A. & Sczakiel, G., 01.12.2009, In: Current Topics in Medicinal Chemistry. 9, 12, p. 1109-1116 8 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Small Interfering RNA 100%
  • Oligodeoxyribonucleotides 20%
  • Oligonucleotides 17%
  • Drug Development 16%
  • Pharmaceutical Preparations 7%
  17 Citations (Scopus)

• RNAi2009 - Fourth international conference and exhibition

  Sczakiel, G., 05.2009, In: IDrugs. 12, 5, p. 278-281 4 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Exhibitions 100%
  • Congresses 67%
  • RNA Interference 32%
  • MicroRNAs 28%
  • Small Interfering RNA 28%