Institute of Chemistry and Metabolomics

2023

Conformational Control of Fast Asparagine Deamidation in a Norovirus Capsid Protein

Creutznacher, R., Schulze-Niemand, E., König, P., Stanojlovic, V., Mallagaray, A., Peters, T., Stein, M. & Schubert, M., 07.03.2023, In: Biochemistry. 62, 5, p. 1032-1043 12 p.

Research output: Journal Articles › Journal articles › Research › peer-review

Food Fingerprinting: LC-ESI-IM-QTOF-Based Identification of Blumeatin as a New Marker Metabolite for the Detection of Origanum majorana Admixtures to O. onites/vulgare

Creydt, M., Flügge, F., Dammann, R., Schütze, B., Günther, U. L. & Fischer, M., 05.2023, In: Metabolites. 13, 5, 673.

Research output: Journal Articles › Journal articles › Research › peer-review

1 Citation (Scopus)

Qualitative and quantitative food authentication of oregano using NGS and NMR with chemometrics

Flügge, F., Kerkow, T., Kowalski, P., Bornhöft, J., Seemann, E., Creydt, M., Schütze, B. & Günther, U. L., 03.2023, In: Food Control. 145, 109497.

Research output: Journal Articles › Journal articles › Research › peer-review

8 Citations (Scopus)

Serum Metabolomic Profiling of Patients with Lipedema

Kempa, S., Buechler, C., Föh, B., Felthaus, O., Prantl, L., Günther, U. L., Müller, M., Derer-Petersen, S., Sina, C., Schmelter, F. & Tews, H. C., 12.2023, In: International Journal of Molecular Sciences. 24, 24, 17437.

Research output: Journal Articles › Journal articles › Research › peer-review

Towards a Precise NMR Quantification of Acute Phase Inflammation Proteins from Human Serum

Mallagaray, A., Rudolph, L., Lindloge, M., Mölbitz, J., Thomsen, H., Schmelter, F., Alhabash, M. W., Abdullah, M. R., Saraei, R., Ehlers, M., Graf, T., Sina, C., Petersmann, A., Nauck, M. & Günther, U. L., 28.08.2023, In: Angewandte Chemie - International Edition. 62, 35, p. e202306154 e202306154.

Research output: Journal Articles › Journal articles › Research › peer-review

2022

Assignment of Ala, Ile, Leu^proS, Met, and Val^proS methyl groups of the protruding domain of murine norovirus capsid protein VP1 using methyl–methyl NOEs, site directed mutagenesis, and pseudocontact shifts

Maass, T., Westermann, L. T., Creutznacher, R., Mallagaray, A., Dülfer, J., Uetrecht, C. & Peters, T., 04.2022, In: Biomolecular NMR Assignments. 16, 1, p. 97-107 11 p.

Research output: Journal Articles › Journal articles › Research › peer-review

Binding of Glycans to the SARS CoV-2 Spike Protein, an Open Question: NMR Data on Binding Site Localization, Affinity, and Selectivity

Maass, T., Ssebyatika, G., Brückner, M., Breckwoldt, L., Krey, T., Mallagaray, A., Peters, T., Frank, M. & Creutznacher, R., 20.12.2022, In: Chemistry - A European Journal. 28, 71, e202202614.

Research output: Journal Articles › Journal articles › Research › peer-review

1 Citation (Scopus)

Dietary methionine starvation impairs acute myeloid leukemia progression

Cunningham, A., Erdem, A., Alshamleh, I., Geugien, M., Pruis, M., Pereira-Martins, D. A., van den Heuvel, F. A. J., Wierenga, A. T. J., ten Berge, H., Dennebos, R., van den Boom, V., Hogeling, S. M., Weinhäuser, I., Knops, R., de Blaauw, P., Heiner-Fokkema, M. R., Woolthuis, C., Günther, U. L., Rego, E. M. & Martens, J. H. A. & 4 others, Jansen, J. H., Schwalbe, H., Huls, G. & Schuringa, J. J., 10.11.2022, In: Blood. 140, 19, p. 2037-2052 16 p.

Research output: Journal Articles › Journal articles › Research › peer-review

10 Citations (Scopus)

Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions

Creutznacher, R., Maass, T., Dülfer, J., Feldmann, C., Hartmann, V., Lane, M. S., Knickmann, J., Westermann, L. T., Thiede, L., Smith, T. J., Uetrecht, C., Mallagaray, A., Waudby, C. A., Taube, S. & Peters, T., 09.06.2022, In: Communications Biology. 5, 1, p. 563 563.

Research output: Journal Articles › Journal articles › Research › peer-review

Enzymatic Sialylation of Synthetic Multivalent Scaffolds: From 3′-Sialyllactose Glycomacromolecules to Novel Neoglycosides

Konietzny, P. B., Peters, H., Hofer, M. L., Gerling-Driessen, U. I. M., de Vries, R. P., Peters, T. & Hartmann, L., 12.2022, In: Macromolecular Bioscience. 22, 12, 2200358.

Research output: Journal Articles › Journal articles › Research › peer-review

NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain

Creutznacher, R., Maass, T., Veselkova, B., Ssebyatika, G., Krey, T., Empting, M., Tautz, N., Frank, M., Kölbel, K., Uetrecht, C. & Peters, T., 27.07.2022, In: Journal of the American Chemical Society. 144, 29, p. 13060-13065 6 p.

Research output: Journal Articles › Journal articles › Research › peer-review

1 Citation (Scopus)

Structural insights into the interaction of antifungal peptides and ergosterol containing fungal membrane

Mohid, S. A., Biswas, K., Won, T. J., Mallela, L. S., Gucchait, A., Butzke, L., Sarkar, R., Barkham, T., Reif, B., Leipold, E., Roy, S., Misra, A. K., Lakshminarayanan, R., Lee, D. K. & Bhunia, A., 01.10.2022, In: Biochimica et Biophysica Acta - Biomembranes. 1864, 10, 183996.

Research output: Journal Articles › Journal articles › Research › peer-review

4 Citations (Scopus)

TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression

Baptista, I., Karakitsou, E., Cazier, J. B., Günther, U. L., Marin, S. & Cascante, M., 01.04.2022, In: International Journal of Molecular Sciences. 23, 7, 3574.

Research output: Journal Articles › Journal articles › Research › peer-review

6 Citations (Scopus)

Using in-tube extraction and slice selective NMR experiments allow imaging via statistical analysis of metabolic profiles

Waschina, S. & Seeger, K., 23.10.2022, In: Analytica Chimica Acta. 1231, 340419.

Research output: Journal Articles › Journal articles › Research › peer-review

2021

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

Vilaplana-Lopera, N., Almaghrabi, R., Papatzikas, G., González, E., Cunningham, A., Erdem, A., Schnuetgen, F., Raghavan, M., Potluri, S., Cazier, J.-B., Schuringa, J. J., Reed, M. A., Günther, U. L. & Garcia, P., 21.01.2021, In: biorxiv.

Research output: Journal Articles › Journal articles › Research › peer-review

Glycan-induced protein dynamics in human norovirus p dimers depend on virus strain and deamidation status

Dülfer, J., Yan, H., Brodmerkel, M. N., Creutznacher, R., Mallagaray, A., Peters, T., Caleman, C., Marklund, E. G. & Uetrecht, C., 02.04.2021, In: Molecules. 26, 8, 2125.

Research output: Journal Articles › Journal articles › Research › peer-review

3 Citations (Scopus)

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

Shepherd, E. L., Saborano, R., Northall, E., Matsuda, K., Ogino, H., Yashiro, H., Pickens, J., Feaver, R. E., Cole, B. K., Hoang, S. A., Lawson, M. J., Olson, M., Figler, R. A., Reardon, J. E., Nishigaki, N., Wamhoff, B. R., Günther, U. L., Hirschfield, G., Erion, D. M. & Lalor, P. F., 04.2021, In: JHEP Reports. 3, 2, p. 100217 100217.

Research output: Journal Articles › Journal articles › Research › peer-review

Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients

Schmelter, F., Föh, B., Mallagaray, A., Rahmöller, J., Ehlers, M., Lehrian, S., von Kopylow, V., Künsting, I., Lixenfeld, A. S., Martin, E., Ragab, M., Meyer-Saraei, R., Kreutzmann, F., Eitel, I., Taube, S., Käding, N., Jantzen, E., Graf, T., Sina, C. & Günther, U. L., 02.12.2021, In: Frontiers in Molecular Biosciences. 8, p. 737039

Research output: Journal Articles › Journal articles › Research › peer-review

NMR experiments shed new light on glycan recognition by human and murine norovirus capsid proteins

Creutznacher, R., Maass, T., Ogrissek, P., Wallmann, G., Feldmann, C., Peters, H., Lingemann, M., Taube, S., Peters, T. & Mallagaray, A., 03.2021, In: Viruses. 13, 3, 416.

Research output: Journal Articles › Journal articles › Research › peer-review

8 Citations (Scopus)

Protein secondary structure affects glycan clustering in native mass spectrometry

Yan, H., Lockhauserbäumer, J., Szekeres, G. P., Mallagaray, A., Creutznacher, R., Taube, S., Peters, T., Pagel, K. & Uetrecht, C., 06.2021, In: Life. 11, 6, 554.

Research output: Journal Articles › Journal articles › Research › peer-review

2 Citations (Scopus)

Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials

Shima, K., Kaufhold, I., Eder, T., Käding, N., Schmidt, N., Ogunsulire, I. M., Deenen, R., Köhrer, K., Friedrich, D., Isay, S. E., Grebien, F., Klinger, M., Richer, B. C., Günther, U. L., Deepe, G. S., Rattei, T. & Rupp, J., 30.03.2021, In: mBio. 12, 2, e00023-21.

Research output: Journal Articles › Journal articles › Research › peer-review

Structural and biophysical characterization of the selenoprotein SelW1 from Chlamydomonas reinhardtii

Schmidt, C. L., Daberger, J., Sobek, M. & Seeger, K., 10.2021, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1869, 10, 140685.

Research output: Journal Articles › Journal articles › Research › peer-review

Targeting asparagine and serine metabolism in germinal centre-derived B cells non-hodgkin lymphomas (B-NHL)

Eraslan, Z., Papatzikas, G., Cazier, J. B., Khanim, F. L. & Günther, U. L., 10.2021, In: Cells. 10, 10, 2589.

Research output: Journal Articles › Journal articles › Research › peer-review

4 Citations (Scopus)

2020

Alcoholic hepatitis and metabolic disturbance in female mice:A more tractable model than Nrf2^−/− animals

Sheriff, L., Khan, R. S., Saborano, R., Wilkin, R., Luu, N. T., Gunther, U. L., Hubscher, S. G., Newsome, P. N. & Lalor, P. F., 29.12.2020, In: DMM Disease Models and Mechanisms. 13, 12, dmm046383.

Research output: Journal Articles › Journal articles › Research › peer-review

1 Citation (Scopus)

Chemical-Shift Perturbations Reflect Bile Acid Binding to Norovirus Coat Protein: Recognition Comes in Different Flavors

Creutznacher, R., Schulze, E., Wallmann, G., Peters, T., Stein, M. & Mallagaray, A., 01.04.2020, In: Chembiochem. 21, 7, p. 1007-1021 15 p.

Research output: Journal Articles › Journal articles › Research › peer-review

1 Citation (Scopus)

Complete assignment of Ala, Ile, Leu^ProS, Met and Val^ProS methyl groups of the protruding domain from human norovirus GII.4 Saga

Müller-Hermes, C., Creutznacher, R. & Mallagaray, A., 01.04.2020, In: Biomolecular NMR Assignments. 14, 1, p. 123-130 8 p.

Research output: Journal Articles › Journal articles › Research › peer-review

Development of a plasmid shuttle vector system for genetic manipulation of chlamydia psittaci

Shima, K., Weber, M. M., Schnee, C., Sachse, K., Käding, N., Klinger, M. & Ruppa, J., 26.08.2020, In: mSphere. 5, 4, 787.

Research output: Journal Articles › Journal articles › Research › peer-review

On-Chip Neo-Glycopeptide Synthesis for Multivalent Glycan Presentation

Mende, M., Tsouka, A., Heidepriem, J., Paris, G., Mattes, D. S., Eickelmann, S., Bordoni, V., Wawrzinek, R., Fuchsberger, F. F., Seeberger, P. H., Rademacher, C., Delbianco, M., Mallagaray, A. & Loeffler, F. F., 06.08.2020, In: Chemistry - A European Journal. 26, 44, p. 9954-9963 10 p.

Research output: Journal Articles › Journal articles › Research › peer-review

2 Citations (Scopus)

Proliferation and Survival of T-cell Acute Lymphoblastic Leukaemia Depends on mTOR-regulated Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides

Stanulović, V. S., Reed, M. A. C., Patani, H., Potluri, S., Georgiadou, E., Roberts, J., Sarkar, S., Pratt, G., Jones, A. M., Günther, U., Ludwig, C. & Hoogenkamp, M., 25.02.2020, In: biorxiv.

Research output: Journal Articles › Journal articles › Research › peer-review

Real-Time NMR Spectroscopy for Studying Metabolism

Alshamleh, I., Krause, N., Richter, C., Kurrle, N., Serve, H., Günther, U. L. & Schwalbe, H., 03.02.2020, In: Angewandte Chemie - International Edition. 59, 6, p. 2304-2308 5 p.

Research output: Journal Articles › Journal articles › Research › peer-review

6 Citations (Scopus)

Simple and Rapid (Extraction) Protocol for NMR Metabolomics-Direct Measurement of Hydrophilic and Hydrophobic Metabolites Using Slice Selection

Seeger, K., 28.12.2020, In: Analytical Chemistry.

Research output: Journal Articles › Journal articles › Research › peer-review

Structural and biophysical characterization of the type VII collagen vWFA2 subdomain leads to identification of two binding sites

Gebauer, J. M., Flachsenberg, F., Windler, C., Richer, B., Baumann, U. & Seeger, K., 01.04.2020, In: FEBS Open Bio. 10, 4, p. 580-592 13 p.

Research output: Journal Articles › Journal articles › Research › peer-review

2019

¹ H-NMR spectroscopy shows cellular uptake of HEPES buffer by human cell lines—an effect to be considered in cell culture experiments

Depping, R. & Seeger, K., 01.02.2019, In: Analytical and Bioanalytical Chemistry. 411, 4, p. 797-802 6 p.

Research output: Journal Articles › Journal articles › Research › peer-review

A framework for tracer-based metabolism in mammalian cells by NMR

Saborano, R., Eraslan, Z., Roberts, J., Khanim, F. L., Lalor, P. F., Reed, M. A. C. & Günther, U. L., 01.12.2019, In: Scientific Reports. 9, 1, 2520.

Research output: Journal Articles › Journal articles › Research › peer-review

9 Citations (Scopus)

A post-translational modification of human Norovirus capsid protein attenuates glycan binding

Mallagaray, A., Creutznacher, R., Dülfer, J., Mayer, P. H. O., Grimm, L. L., Orduña, J. M., Trabjerg, E., Stehle, T., Rand, K. D., Blaum, B. S., Uetrecht, C. & Peters, T., 01.12.2019, In: Nature Communications. 10, 1, 1320.

Research output: Journal Articles › Journal articles › Research › peer-review

21 Citations (Scopus)

Detecting acetylated aminoacids in blood serum using hyperpolarized ¹³C-¹Η-2D-NMR

Katsikis, S., Marin-Montesinos, I., Ludwig, C. & Günther, U. L., 08.2019, In: Journal of Magnetic Resonance. 305, p. 175-179 5 p.

Research output: Journal Articles › Journal articles › Research › peer-review

2 Citations (Scopus)

Fragment Growing to Design Optimized Inhibitors for Human Blood Group B Galactosyltransferase (GTB)

Strecker, C., Peters, H., Hackl, T., Peters, T. & Meyer, B., 17.07.2019, In: ChemMedChem. 14, 14, p. 1336-1342 7 p.

Research output: Journal Articles › Journal articles › Research › peer-review

1 Citation (Scopus)

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Wierenga, A. T. J., Cunningham, A., Erdem, A., Lopera, N. V., Brouwers-Vos, A. Z., Pruis, M., Mulder, A. B., Günther, U. L., Martens, J. H. A., Vellenga, E. & Schuringa, J. J., 27.12.2019, In: Cancer & Metabolism. 7, 1, 11.

Research output: Journal Articles › Journal articles › Research › peer-review

How clinical biobanks can support precision medicine: from standardized preprocessing to treatment guidance

Flügge, F., Figge, L., Duhm-Harbeck, P., Kammler, R. & Habermann, J. K., 02.11.2019, In: Expert Review of Precision Medicine and Drug Development. 4, 6, p. 309-316 8 p.

Research output: Journal Articles › Journal articles › Research › peer-review

Impacts of platelet-rich fibrin and platelet-rich plasma on primary osteoblast adhesion onto titanium implants in a bisphosphonate in vitro model

Steller, D., Herbst, N., Pries, R., Juhl, D., Klinger, M. & Hakim, S. G., 01.11.2019, In: Journal of Oral Pathology and Medicine. 48, 10, p. 943-950 8 p.

Research output: Journal Articles › Journal articles › Research › peer-review

3 Citations (Scopus)

Insights into Allosteric Control of Human Blood Group A and B Glycosyltransferases from Dynamic NMR

Flügge, F. & Peters, T., 06.2019, In: ChemistryOpen. 8, 6, p. 760-769 10 p.

Research output: Journal Articles › Journal articles › Research › peer-review

Maternally inherited differences within mitochondrial complex I control murine healthspan

Hirose, M., Schilf, P., Zarse, K., Busch, H., Fuellen, G., Jöhren, O., Köhling, R., König, I. R., Richer, B., Rupp, J., Schwaninger, M., Seeger, K., Sina, C., Ristow, M. & Ibrahim, S. M., 07.2019, In: Genes. 10, 7, 532.

Research output: Journal Articles › Journal articles › Research › peer-review

PhenoMeNal: processing and analysis of metabolomics data in the cloud

Peters, K., Bradbury, J., Bergmann, S., Capuccini, M., Cascante, M., de Atauri, P., Ebbels, T. M. D., Foguet, C., Glen, R., Gonzalez-Beltran, A., Günther, U. L., Handakas, E., Hankemeier, T., Haug, K., Herman, S., Holub, P., Izzo, M., Jacob, D., Johnson, D. & Jourdan, F. & 36 others, Kale, N., Karaman, I., Khalili, B., Emami Khonsari, P., Kultima, K., Lampa, S., Larsson, A., Ludwig, C., Moreno, P., Neumann, S., Novella, J. A., O'Donovan, C., Pearce, J. T. M., Peluso, A., Piras, M. E., Pireddu, L., Reed, M. A. C., Rocca-Serra, P., Roger, P., Rosato, A., Rueedi, R., Ruttkies, C., Sadawi, N., Salek, R. M., Sansone, S. A., Selivanov, V., Spjuth, O., Schober, D., Thévenot, E. A., Tomasoni, M., van Rijswijk, M., van Vliet, M., Viant, M. R., Weber, R. J. M., Zanetti, G. & Steinbeck, C., 01.02.2019, In: GigaScience. 8, 2

Research output: Journal Articles › Journal articles › Research › peer-review

18 Citations (Scopus)

Quantitative Isotopomer Rates in Real-Time Metabolism of Cells Determined by NMR Methods

Reed, M. A. C., Roberts, J., Gierth, P., Kupče, Ē. & Günther, U. L., 02.09.2019, In: Chembiochem. 20, 17, p. 2207-2211 5 p.

Research output: Journal Articles › Journal articles › Research › peer-review

3 Citations (Scopus)

The Metabolic Profile of Stable Ischemic Heart Disease by Serum ¹H NMR

Titma, T., Shin, M. J., Ludwig, C., Günther, U. L., Pikta, M., Zemtsovskaja, G., Viigimaa, M., Tanner, R. & Samoson, A., 01.04.2019, In: Applied Magnetic Resonance. 50, 4, p. 527-539 13 p.

Research output: Journal Articles › Journal articles › Research › peer-review

1 Citation (Scopus)

2018

Changes in Neutrophil Metabolism upon Activation and Aging

Richer, B. C., Salei, N., Laskay, T. & Seeger, K., 01.03.2018, In: Inflammation. 41, 2, p. 710-721 12 p.

Research output: Journal Articles › Journal articles › Research › peer-review

Complete assignment of Ala, Ile, Leu, Met and Val methyl groups of human blood group A and B glycosyltransferases using lanthanide-induced pseudocontact shifts and methyl–methyl NOESY

Flügge, F. & Peters, T., 01.04.2018, In: Journal of Biomolecular NMR. 70, 4, p. 245-259 15 p.

Research output: Journal Articles › Journal articles › Research › peer-review

3 Citations (Scopus)

Fucose-Functionalized Precision Glycomacromolecules Targeting Human Norovirus Capsid Protein

Bücher, K. S., Yan, H., Creutznacher, R., Ruoff, K., Mallagaray, A., Grafmüller, A., Dirks, J. S., Kilic, T., Weickert, S., Rubailo, A., Drescher, M., Schmidt, S., Hansman, G., Peters, T., Uetrecht, C. & Hartmann, L., 10.09.2018, In: Biomacromolecules. 19, 9, p. 3714-3724 11 p.

Research output: Journal Articles › Journal articles › Research › peer-review

12 Citations (Scopus)

Glycans controlling virus infections: Meeting report on the 1st international symposium on glycovirology Schöntal, Germany, 02–04 May 2018

Stehle, T., Peters, T., Hartmann, L. & Schelhaas, M., 15.11.2018, In: Viruses. 10, 11, 636.

Research output: Journal Articles › Journal articles › Research › peer-review

Interferon-γ interferes with host cell metabolism during intracellular Chlamydia trachomatis infection

Shima, K., Kaeding, N., Ogunsulire, I. M., Kaufhold, I., Klinger, M. & Rupp, J., 01.01.2018, In: Cytokine.

Research output: Journal Articles › Journal articles › Research › peer-review

Institute of Chemistry and Metabolomics

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