Clinic of Internal Medicine I

Projects

Projects per year 1993 2005 2014 2015 2023

• 1 Active
• 44 Finished

Projects per year

Search results

• Active

  Clinician Scientist School Luebeck: Connecting Brain, Metabolism, and Inflammation (BMI) – Mechanisms and Disease Expression

  Sadik, C., Busch, H. S., Erdmann, J., Grünewald, A. K., Ibrahim, S., Kaiser, F., Keck, T., Klein, C., Köhl, J., König, I. R., Lehnert, H., Lohmann, K., Münte, T., Nau, C., Oster, H., Riemekasten, G., Rupp, J., Schwaninger, M., Sina, C., Tronnier, V. M., Wollenberg, B. & Zillikens, D.

  01.01.18 → …

  Project: DFG Projects › DFG Clinician Scientist School Programme

  • clinician 100%
• Finished

  CRC 1292, Project 07: Defining the role of hepatocellular carcinoma-related epigenetic alterations driving immune evasion

  Marquardt, J. & Strand , S.

  01.01.18 → 31.12.21

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • Epigenomics 100%
  • Immune Evasion 28%

• CRC/Transregio TRR 134, Project C07: Changing nutrition, changing brain, changing obesity

  Q. Park , S. Y. & Schmid, S.

  01.01.15 → 31.12.18

  Project: DFG Projects › DFG Individual Projects

  • Food 100%
  • Nutrients 81%
  • Eating 71%
  • Neutral Amino Acids 68%
  • Choice Behavior 65%

• SPP 1629, Subproject: Integrated-OMICs analyses to identify pathways associated with thyroid hormones and their molecular regulators: Screening for new markers to assess thyroid hormone action

  Brabant, E. G., Friedrich, N., Führer-Sakel, D. & Völker, U.

  01.01.15 → 31.12.19

  Project: DFG Projects › DFG Joint Research: Priority Programs

  • Thyroid Hormones 100%
  • Hypothyroidism 36%
  • thyronamine 36%

• SPP 1629, Subproject: Role of the murine thyroid hormone transporters Mct8 and Oatp1c1 in skeletal muscle, cardiovascular and metabolic system

  Heuer, H. & Mittag, J.

  01.01.15 → 31.12.18

  Project: DFG Projects › DFG Joint Research: Priority Programs

  • Thyroid Hormones 100%
  • Allan-Herndon-Dudley syndrome 45%
  • Knockout Mice 45%
  • Skeletal Muscle 29%

• Emmy Noether Research Group: Epigenetic regulation of hepatic gene expression in the pathogenesis of insulin resistance

  Kirchner, H.

  01.01.15 → 31.12.23

  Project: DFG Projects › DFG Scholarships: Emmy Noether Programme

  • insulin resistance 100%
  • liver 87%
  • mice 78%
  • epigenetics 53%
  • funding 45%

• SPP 1629, Subproject: Unraveling the molecular basis for successful thyroid hormone replacement therapy

  Brabant, E. G., Mittag, J., Völker, U. & Schomburg, L.

  01.01.15 → 31.12.19

  Project: DFG Projects › DFG Joint Research: Priority Programs

  • Thyroid Hormones 100%
  • Thyroid Hormone Receptors 37%
  • Thyroid Gland 35%
  • Hormone Replacement Therapy 32%
  • Metabolome 32%

• SPP 1629, Subproject: Non Classical Concepts of Thyroid Hormone Action in the Regulation of Body Temperature

  Mittag, J.

  01.01.15 → 31.12.19

  Project: DFG Projects › DFG Joint Research: Priority Programs

  • thyroid hormones 100%
  • thermoregulation 44%
  • metabolites 35%
  • heat production 28%
  • body temperature 25%

• Central Control of Cardiovascular Function and Energy Expenditure by Thyroid Hormone

  Mittag, J.

  01.06.14 → 31.12.23

  Project: DFG Projects › DFG Individual Projects

  • Thyroid Hormones 100%
  • Thyroid Hormone Receptors 32%
  • Parvalbumins 31%
  • Neurons 30%
  • Hyperthyroidism 26%

• Heisenberg Professorship for Endocrinology: Central Control of Cardiovascular Function and Energy Expenditure by Thyroid Hormone

  Mittag, J.

  01.06.14 → 31.05.19

  Project: DFG Projects › DFG Scholarships: Heisenberg Programme

  • endocrinology 100%
  • leadership 68%
  • program 65%
  • hormone 65%
  • expenditure 63%

• RTG 1957: Adipocyte-Brain Crosstalk

  Oster, H., Bader, M., Kannenberg, S., Brüggemann, N., Heldmann, M., Iwen, A., Jöhren, O., Kirchner, H., Lehnert, H., Mittag, J., Münte, T., Raasch, W., Schmid, S., Schulz, C., Schwaninger, M., Wenzel, J. & Wilms, B.

  01.05.14 → 30.04.23

  Project: DFG Projects › DFG Joint Research: Research Training Groups

  • Adipocytes 100%
  • Adipose Tissue 52%
  • Adipokines 48%
  • Central Nervous System 46%
  • Brain 41%

• CRC/Transregio TRR 134, Project B05: Exploring the effects of nesfatin-1 in reward-associated and compulsive-like eating

  Lehnert, H. & Schulz, C.

  01.01.14 → 31.12.18

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • Reward 100%
  • Food Addiction 39%
  • Pleasure 30%
  • Oxytocin 28%
  • Feeding and Eating Disorders 27%

• CRC/Transregio TRR 134, Project C03: Metabolic-cognitive control of food choices and long-term dietary success in ageing

  Brassen, S., Büchel, C. & Klement, J.

  01.01.14 → 31.12.18

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • food choices 100%
  • weight control 38%
  • obesity 32%
  • food intake 27%
  • insulin 27%

• CRC/Transregio TRR 134, Project B02: The interplay between hedonic and hormonal stimuli in the central regulation of energy and glucose metabolism in humans

  Klement, J., Lehnert, H. & Ott, V.

  01.01.14 → 01.01.18

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • oxytocin 100%
  • appetite suppressants 87%
  • food intake 78%
  • glucose 71%
  • funding 66%

• CRC/Transregio TRR 134, Project B01: Circadian clocks and hedonic appetite regulation

  Oster, H. & Schmid, S.

  01.01.14 → 31.12.18

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • Appetite Regulation 100%
  • Circadian Clocks 62%
  • Pleasure 58%
  • Appetite 26%

• CRC/Transregio TRR 134, Project A05: 4D Multi object segmentation based on MR image sequences - Medical application for evaluation of myocardial differences in shape and function after infarction

  Lehnert, H. & Schulz, C.

  01.01.14 → 01.01.17

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

• CRC/Transregio TRR 134, Project C06: Using machine learning to identify multivariate neural determinants of food choice in the human brain

  Anders, S., Martinetz, T. & Schmid, S.

  01.01.14 → 01.01.17

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

• CRC/Transregio TRR 134: Ingestive Behaviour: Homeostasis and Reward

  Lehnert, H.

  01.01.14 → 31.12.18

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • Reward 100%
  • Feeding Behavior 66%
  • Translational Medical Research 39%
  • Interpersonal Relations 36%
  • Cues 30%

• CRC/Transregio TRR 134, Project Z02: Generation of a reference cohort with extreme eating behaviour

  Brabant, E. G., Brüning, J. C., Kasten, M., Kirchner, H., Klein, C., Krämer, U. & Lill, C. M.

  01.01.14 → 31.12.18

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • Feeding Behavior 100%
  • Epidemiologic Confounding Factors 60%
  • Biocompatible Materials 52%
  • Body Weight 36%
  • Phenotype 31%

• Keeping it cool: Elucidating the actions of thyronamines in thermoregulation and cardiovascular function

  Hoefig, C. S., Mittag, J. & Vennström, B.

  01.01.13 → 31.12.15

  Project: DFG Projects › DFG Individual Projects

  • 3-iodothyronamine 100%
  • 3-iodothyroacetic acid 49%
  • thyronamine 45%
  • Trace amine-associated receptor 1 34%
  • 3-monoiodothyronine 33%

• CRC 654, Project B08: Sleep-dependent plasticity and metabolism during early life

  Fritsche, A., Hallschmid, M. & Preissl, H.

  01.01.13 → 31.12.17

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

• SPP 1629, Subproject: The influence of thyroid hormones, receptors, and transporters on brain structure and function

  Brabant, E. G., Münte, T. & Sartorius, A.

  01.01.12 → 31.12.19

  Project: DFG Projects › DFG Joint Research: Priority Programs

  • Thyroid Hormones 100%
  • Hyperthyroidism 53%
  • Multimodal Imaging 43%
  • Thyroid Hormone Receptors 43%
  • Hypothyroidism 33%

• Dissecting the heterogeneity of tumor-initiating cells in hepatobiliary cancers: molecular characterization and targeting of stemness features

  Marquardt, J.

  01.01.12 → 31.12.20

  Project: DFG Projects › DFG Individual Projects

  • Liver Neoplasms 100%
  • Neoplastic Stem Cells 58%

• CRC 654, Project B07: The regulatory role of sleep for food intake and energy metabolism

  Benedict, C. & Oltmanns, K.

  01.01.09 → 31.12.13

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

• CRC 654, Project B05: Sleep-body weight interactions: from clock genes to behavior

  Lehnert, H. & Oster, H.

  01.01.09 → 31.12.13

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

• CRU 126, Subproject: Ingestion and cognition - The influence of anticipation, perception and sleep deprivation on food intake

  Hallschmid, M., Jauch-Chara, K. & Lehnert, H.

  01.01.08 → 31.12.11

  Project: DFG Projects › DFG Joint Research: Research Units/ Clinical Research Units

  • Insulin 100%
  • Eating 89%
  • Intranasal Administration 67%
  • Sleep 43%
  • Insulin Detemir 39%

• The influence of activated coagulation factors on the progression of tumor cells in malignant effusions

  Gieseler, F.

  01.01.07 → 31.12.12

  Project: DFG Projects › DFG Individual Projects

• Analysis of the endocrine regulation of metabolism in mice with a dominant negative mutation in the thyroid hormone receptor alpha1

  Mittag, J.

  01.01.07 → 31.12.10

  Project: DFG Projects › DFG Individual Projects

  • Thyroid Hormone Receptors 100%
  • Thyroid Hormone Receptors alpha 63%
  • Nervous System 31%
  • Mutation 28%
  • Thyroid Hormones 28%

• Central nervous and metabolic effects of intranasal leptin in diet induced obesity and studies on leptin receptor signal transduction induced by leptin fragments

  Schulz, C.

  01.01.06 → 31.12.09

  Project: DFG Projects › DFG Individual Projects

  • leptin 100%
  • obesity 49%
  • leptin receptors 39%
  • blood-brain barrier 26%

• Corticosteroid Receptor-Mediated Control of Endocrine Adipocyte Function

  Klein, J.

  01.01.06 → 31.12.12

  Project: DFG Projects › DFG Individual Projects

  • Adipocytes 100%
  • White Adipocytes 79%
  • Adipokines 66%
  • Brown Adipocytes 35%
  • Cannabinoid Receptors 34%

• CRC 654, Project B03: Setpoint regulation during sleep: Influence of intranasal neuropeptides on human neuroendocrine sleep architecture and body weight

  Kern, W. & Perras, B.

  01.01.05 → 31.12.09

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • sleep 100%
  • neuropeptides 79%
  • intranasal administration 29%

• CRC 654, Project B01: Sleep-associated learning processes of energy homeostasis

  Hallschmid, M. & Schmid, S.

  01.01.05 → 31.12.17

  Project: DFG Projects › DFG Individual Projects

• CRU 126, Subproject: Central glucose feedback and brain corticosteroid feedback in the energy push-pull principle

  Peters, A. & Langemann, D.

  01.01.05 → 31.12.11

  Project: DFG Projects › DFG Joint Research: Research Units/ Clinical Research Units

  • Brain 100%
  • Addison Disease 66%
  • Physiological Adaptation 62%
  • Obesity 61%
  • supply balance 60%

• CRC 654, Project B04: Sleep-dependent cardiovascular and respiratory regulation in adults and infants

  Poets, C. F. & Sayk, F.

  01.01.05 → 31.12.17

  Project: DFG Projects › DFG Individual Projects

• CRU 126, Subproject: Selfish Brain - Brain Glucose and Metabolic Syndrome

  Hohagen, F. & Peters, A.

  01.01.05 → 31.12.10

  Project: DFG Projects › DFG Joint Research: Research Units/ Clinical Research Units

  • Brain 100%
  • Pituitary-Adrenal System 76%
  • Obesity 52%
  • Glucose 51%
  • Hypothalamus 50%

• CRU 126, Subproject: The role of brain corticosteroid feedback for glucose regulation

  Peters, A., Fehm, H. L. & Prestin, J.

  01.01.05 → 31.12.08

  Project: DFG Projects › DFG Joint Research: Research Units/ Clinical Research Units

  • Adrenal Cortex Hormones 100%
  • Glucose 78%
  • Brain 60%

• Research Unit RU 457, Subproject: Setpoint setting during sleep: the influence of central nervous system hormones on body weight

  Kern, W.

  01.01.02 → 31.12.07

  Project: DFG Projects › DFG Joint Research: Research Units/ Clinical Research Units

• RU 457, Project: "Reset" and consolidation of the glucose setpoint during sleep in healthy subjects and diabetics: A mathematical modeling based on experimental data

  Peters, A., Fischer, B. & Schultes, B.

  01.01.02 → 31.12.07

  Project: DFG Projects › DFG Joint Research: Research Units/ Clinical Research Units

• Physiological and pathophysiological regulation of topoisomerase II alpha during a cell cycle after inhibition by etoposide

  Gieseler, F. & Kroll, D.

  01.01.01 → 31.12.05

  Project: DFG Projects › DFG Individual Projects

• CRC 426: Studies on the influence of insulin and leptin on hippocampal-mediated memory processes

  Lehnert, H.

  01.01.01 → 31.12.02

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • Leptin 100%
  • Memory 73%
  • Insulin 68%

• Interdisciplinary study of molecular genetic analysis of patients with craniofacial dysplasias.

  Kramer , F. & Brabant, E. G.

  01.01.00 → 31.12.02

  Project: DFG Projects › DFG Individual Projects

  • Molecular Biology 100%
  • Interdisciplinary Studies 64%
  • Fibroblast Growth Factor Receptors 52%
  • Craniosynostoses 52%
  • Genes 49%

• Neuroendocrine regulation of fat cell function

  Klein, J.

  01.01.00 → 31.12.07

  Project: DFG Projects › DFG Individual Projects

• Analyse der Signaltransduktionswege und nukleären Expressionskontrolle des humanen Biglykan-Gens bei der Induktion durch TGF-beta und der Repression durch TNF-alpha

  Ungefroren, H.

  01.01.00 → 31.12.03

  Project: DFG Projects › DFG Individual Projects

• CRC 367, Project B03: Influence of defined virulence factors of uropathogenic Escherichia coli on the production of 1,25-dihydroxycholecalciferol of human tubular epithelial cells and their interaction with homologous T lymphocytes

  Kreft , B.

  01.01.93 → 31.12.00

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • Uropathogenic Escherichia coli 100%
  • Calcitriol 83%
  • Virulence Factors 73%
  • Cell Communication 66%
  • Epithelial Cells 50%

• CRC 367, Project B6: The immunopathogenic role of enteropathogenic Yersinia enterocolitica (YE) in autoimmune thyroid diseases (AISE)

  Wenzel, B.

  01.01.93 → 31.12.96

  Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios