Wirkungen niedriger coffeindosen auf das befinden bei vermuteter analgetikaeinnahme: Ein experimenteller beitrag zur mißbrauchsdiskussion - Kurzbericht

Caffeine is expected to initiate the abuse of caffeine-containing analgesics. The study investigated effects of doses of caffeine as usually added to analgesics on mood and cardiovascular parameters. 45 healthy middle-aged women were randomly assigned to receive caffeine 50 mg, 100 mg or placebo administered in a double blind design. Subjects were not required to abstain from caffeine before session. They expected the application of an over-the-counter analgesic and received during session pain induction through mechanical stimulation. Neither dose of caffeine affected blood pressure or heart rate. Compared to placebo caffeine changed ratings of negative mood scales, but did not influence scores on any of the scales reflecting "positive" mood aspects.