When oxygen runs short: The microenvironment drives host-pathogen interactions

Inga Dietz; Stefan Jerchel; Márta Szaszák; Kensuke Shima; Jan Rupp

doi:10.1016/j.micinf.2011.11.003

When oxygen runs short: The microenvironment drives host-pathogen interactions

Inga Dietz, Stefan Jerchel, Márta Szaszák, Kensuke Shima, Jan Rupp^*

^*Korrespondierende/r Autor/-in für diese Arbeit

29 Zitate (Scopus)

Abstract

Pathogens that colonize or infect the human body have to face varying oxygen concentrations within different organs. Inflammation itself promotes oxygen consumption within affected tissues and creates a low oxygen environment. As a consequence, pathogens and the host immune system have to adapt to rapid changes in oxygen availability. Here we summarize recent findings on the adaptation of pathogens, host defense mechanisms and treatment strategies against intracellular pathogens in a low oxygen environment.

Originalsprache	Englisch
Zeitschrift	Microbes and Infection
Jahrgang	14
Ausgabenummer	4
Seiten (von - bis)	311-316
Seitenumfang	6
ISSN	1286-4579
DOIs	https://doi.org/10.1016/j.micinf.2011.11.003
Publikationsstatus	Veröffentlicht - 01.04.2012

Fördermittel

Work in the laboratory is supported by the BMBF in the frame of ERA-Net PathoGenoMics (Pathomics) and the DFG Excellence Cluster “Inflammation at Interfaces” (RA I-f).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Dokumente

10.1016/j.micinf.2011.11.003

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When oxygen runs short: The microenvironment drives host-pathogen interactions

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

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