Wassergefilterte Infrarot-A-Hyperthermie, kombiniert mit Radiotherapie bei fortgeschrittenen und rezidivierten Tumoren

M. Heinrich Seegenschmiedt*, G. Klautke, E. Walther, H. J. Feldmann, A. Katalinic, M. Stuschke, H. Von Lieven, Peter Vaupel

*Korrespondierende/r Autor/-in für diese Arbeit
12 Zitate (Scopus)


Background: Water-filtered infrared-A-radiation (IR/A-HT) can be used to heat superficial malignant tumors. A prospective multicenter phase I-II study was conducted to evaluate toxicity and efficacy of IR/A-HT combined with external beam radiotherapy (RT). Patients, Material and Methods: From December 1991 to June 1994, a total of 53 patients with 58 malignant lesions were entered in the study. There were 14 primary, 36 recurrent and 8 metastatic tumors which were located in the head and neck region (14), chestwall (31), abdominal wall (2) and the extremities (11). The mean tumor volume was 100 cm 3. IR/A-HT was applied 1 to 2 times per week with up to 3 IR/A-HT-radiators directly before or after external RT for 1 hour at 40.5 to 44°C. Temperatures were controlled at various locations at the skin surface and invasively at depth. Results: IR/A-HT was well tolerated: in 31 (53%) lesions acute (pain, pulse- or blood pressure changes, increased skin reaction etc.) and in 25 (43%) chronic side-effects (atrophy, teleangiectasia, fibrosis etc.) were noted; usually the toxicity was minor and temporary. At 3 months FU, 32 (55%) lesions achieved a local CR and 19 (33%) a PR; at 12 months FU, 25 (43%) had persistent CR; 16 patients (18 lesions) were deceased and 3 (4 lesionen) not yet in FU. In univariate analysis the following prognostic factors for CR at 3 or 12 months FU were found: Karnofsky, metastatic status, tumor size, total RT-dose, thermal parameters T(min)(av) and T(mean). For acute toxicity maximum temperature T(max)(av) was prognostically decisive. Significant differences were also found when considering the 'quality of the HT-application'. The microwave technique was superior to the infrared-A-HT-technique with regard to the penetration depth of energy deposition. Conclusions: Water-filtered infrared-A-radiation can be safely and effectively applied to heat localized superficial tumors (up to 1 cm depth). To increase the area of HT application multiple infrared-A-radiators have to be combined. A multi-element-system is in progress.

Titel in ÜbersetzungWater-filtered infrared-A-hyperthermia combined with radiotherapy for advanced and recurrent tumors
ZeitschriftStrahlentherapie und Onkologie
Seiten (von - bis)475-484
PublikationsstatusVeröffentlicht - 01.09.1996


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