TY - JOUR
T1 - Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman
AU - Elter, Thomas
AU - Sieniawski, Michal
AU - Gossmann, Axel
AU - Wickenhauser, Claudia
AU - Schröder, Ursula
AU - Seifert, Harald
AU - Kuchta, Johannes
AU - Burhenne, Jürgen
AU - Riedel, Klaus Dieter
AU - Fätkenheuer, Gerd
AU - Cornely, Oliver A.
PY - 2006/9
Y1 - 2006/9
N2 - Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.
AB - Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.
UR - http://www.scopus.com/inward/record.url?scp=33747133236&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2006.04.006
DO - 10.1016/j.ijantimicag.2006.04.006
M3 - Journal articles
C2 - 16908120
AN - SCOPUS:33747133236
SN - 0924-8579
VL - 28
SP - 262
EP - 265
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 3
ER -
