We present an endomicroscopic OCT probe for in vivo examination of the mucosa in the nose based on a voice coil actuator. The side-viewing endoscope has a tip diameter of 3 mm and a usable length of 7 cm. A graded-index (GRIN) lens optics achieve a lateral resolution of 3 µm. At an actuator frequency between 40 Hz and 100 Hz the scanning range is up to 2 mm. A supercontinuum laser based mOCT system enables an axial resolution of 1 µm at a depth range of 700 µm. The postprocessing includes the linearization of the sinusoidal scan pattern and a registration of the time series from B-scans. The potential of the new design was demonstrated on ex-vivo mouse trachea. Essential morphological structures such as epithelium with ciliated cells, glands, blood and lymph vessels and also mucus transport were be visualized.
|Proceedings Volume 11620 : Endoscopie Microscopy XVI
|Veröffentlicht - 05.03.2021