Vertical sleeve gastrectomy improves social behaviors in obese, male mice

Anne Marie Neumann; Cathleen Geißler; Randy Seeley; Henriette Kirchner; Henrik Oster

doi:10.1016/j.orcp.2025.02.003

Vertical sleeve gastrectomy improves social behaviors in obese, male mice

Anne Marie Neumann, Cathleen Geißler, Randy Seeley, Henriette Kirchner, Henrik Oster^*

^*Korrespondierende/r Autor/-in für diese Arbeit

University of Michigan

Abstract

Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.

Originalsprache	Englisch
Zeitschrift	Obesity Research and Clinical Practice
Jahrgang	19
Ausgabenummer	1
Seiten (von - bis)	80-83
Seitenumfang	4
ISSN	1871-403X
DOIs	https://doi.org/10.1016/j.orcp.2025.02.003
Publikationsstatus	Veröffentlicht - 01.01.2025

Fördermittel

This work was supported by grants from the German Research Foundation (DFG; GRK-1957, KI1887/2-1 and OS353/10-1).

Träger	Trägernummer
Deutsche Forschungsgemeinschaft	KI1887/2-1, OS353/10-1, GRK-1957

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
Querschnittsbereich: Medizinische Genetik

DFG-Fachsystematik

2.22-17 Endokrinologie, Diabetologie, Metabolismus
2.23-04 Kognitive, systemische und Verhaltensneurobiologie

KDSF-Klassifikation für Forschungsfelder

231 - Zellen und Gene

Dokumente

10.1016/j.orcp.2025.02.003

Weitere Links

2 Abgeschlossen

SFB/TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung
Führer-Sakel, D. (Sprecher*in), Mittag, J. (Stellv. Sprecher*in, Co-Sprecher*in), Kühnen, P. (Stellv. Sprecher*in, Co-Sprecher*in), Heuer, H. (Projektleiter*in (PI)), Schwaninger, M. (Projektleiter*in (PI)), Müller-Fielitz, H. (Projektleiter*in (PI)), Bechmann, I. (Projektleiter*in (PI)), Biebermann, H. (Projektleiter*in (PI)), Müller, T. (Projektleiter*in (PI)), Pfluger, P. (Projektleiter*in (PI)), Krude, H. (Projektleiter*in (PI)), Schülke-Gerstenfeld, M. (Projektleiter*in (PI)), Cirkel, A. (Projektleiter*in (PI)), Münte, T. (Projektleiter*in (PI)), Kleinschnitz, C. (Projektleiter*in (PI)), Langhauser, F. (Projektleiter*in (PI)), Engel, D. R. (Projektleiter*in (PI)), Möller, L. (Projektleiter*in (PI)), Kaiser, F. (Projektleiter*in (PI)), Oster, H. (Projektleiter*in (PI)), Kirchner, H. (Projektleiter*in (PI)), Spranger, J. (Projektleiter*in (PI)), Tacke, F. (Projektleiter*in (PI)), Wirth, E. K. (Projektleiter*in (PI)), Köhrle, J. (Projektleiter*in (PI)), Schomburg, L. (Projektleiter*in (PI)), Lange, C. M. (Projektleiter*in (PI)), Zwanziger, D. (Projektleiter*in (PI)), Mayerl, S. (Projektleiter*in (PI)), Stachelscheid, H. (Projektleiter*in (PI)), Opitz, R. (Projektleiter*in (PI)), Prasuhn, J. (Projektleiter*in (PI)), Lorenz, K. (Projektleiter*in (PI)), Köster, J. (Projektleiter*in (PI)), Mai, K. (Projektleiter*in (PI)), Püngel, T. (Projektleiter*in (PI)), Obermayer, B. (Projektleiter*in (PI)) & Rehwald, S. (Projektleiter*in (PI))
01.01.20 → 31.12.25
Projekt: DFG Verbundprojekte › DFG Sonderforschungsbereiche / Transregios (SFB/TR)

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title = "Vertical sleeve gastrectomy improves social behaviors in obese, male mice",

abstract = "Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.",

author = "Neumann, \{Anne Marie\} and Cathleen Gei{\ss}ler and Randy Seeley and Henriette Kirchner and Henrik Oster",

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doi = "10.1016/j.orcp.2025.02.003",

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AU - Neumann, Anne Marie

AU - Geißler, Cathleen

AU - Seeley, Randy

AU - Kirchner, Henriette

AU - Oster, Henrik

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.

AB - Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.

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Vertical sleeve gastrectomy improves social behaviors in obese, male mice

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

KDSF-Klassifikation für Forschungsfelder

Dokumente

Weitere Links

Fingerprint

Projekte

SFB/TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung

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