Uptake of 18F-fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis

Matthias T. Wyss, Nicolas Spaeth, Gregoire Biollaz, Jens Pahnke, Patrizia Alessi, Eveline Trachsel, Valerie Treyer, Bruno Weber, Dario Neri, Alfred Buck*

*Korrespondierende/r Autor/-in für diese Arbeit
36 Zitate (Scopus)

Abstract

Targeting extracellular structures that are involved in angiogenic processes, such as the extra domain B of fibronectin, is a promising approach for the diagnosis of solid tumors. The aim of this study was to determine uptake of the 18F-labeled PET tracers 18F-fluorocholine (N,N-dimethyl-N-18F-fluoromethyl-2-hydroxyethylammonium), 18F-fluoro-ethyl-L-tyrosine (FET), and 18F-FDG in C6 gliomas of the rat and to correlate it with uptake of the anti-extra domain B antibody 131I-SIP(L19) as a marker of neoangiogenesis. Methods: C6 gliomas were orthotopically induced in 17 rats. Uptake of all tracers was measured using quantitative autoradiography, and uptake of 18F- fluorocholine, 18F-FET, and 18F-FDG was correlated with uptake of 131ISIP( L19) on a pixelwise basis. Results: The mean 131I-SIP(L19), 18F-fluorocholine, 18F-FET, and 18F-FDG standardized uptake values in the tumor and the contralateral normal cortex (in parentheses) were 0.31 ± 0.22 (not detectable), 2.00 ± 0.53 (0.49 ± 0.07), 3.67 ± 0.36 (1.42 ± 0.22), and 7.23 ± 1.22 (3.64 ± 0.51), respectively. The 131I- SIP(L19) uptake pattern correlated best with 18F-fluorocholine uptake (ż = 0.80, averaged ż-transformed Pearson correlation coefficient) and 18F-FET uptake (ż = 0.79) and least with 18F-FDG (ż = 0.37). Conclusion: One day after intravenous injection, 131I-SIP(L19) displayed a very high tumorto-cortex ratio, which may be used in the diagnostic work-up of brain tumor patients. Of the 3 investigated 18F tracers, 18F-fluorocholine and 18F-FET correlated better with the pattern of 131I-SIP(L19) uptake than did 18F-FDG. Whether this means that 18F-fluorocholine and 18F-FET are better suited than 18F-FDG to monitor antiangiogenic therapy should be investigated in future studies.

OriginalspracheEnglisch
ZeitschriftJournal of Nuclear Medicine
Jahrgang48
Ausgabenummer4
Seiten (von - bis)608-614
Seitenumfang7
ISSN0161-5505
DOIs
PublikationsstatusVeröffentlicht - 01.04.2007

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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