Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Sophie Steiner; Annick Fehrer; Friederike Hoheisel; Simon Schoening; Anna Aschenbrenner; Nina Babel; Judith Bellmann-Strobl; Carsten Finke; Øystein Fluge; Laura Froehlich; Andreas Goebel; Bettina Grande; Johannes Peter Haas; Bettina Hohberger; Leonard A. Jason; Anthony L. Komaroff; Eliana Lacerda; Max Liebl; Andrea Maier; Olav Mella; Luis Nacul; Friedemann Paul; Bhupesh K. Prusty; Christian Puta; Gabriela Riemekasten; Wolfgang Ries; Peter C. Rowe; Birgit Sawitzki; Yehuda Shoenfeld; Joachim L. Schultze; Martina Seifert; Nuno Sepúlveda; Franziska Sotzny; Elisa Stein; Michael Stingl; Friederike Ufer; Christian Veauthier; Francisco Westermeier; Klaus Wirth; Bernd Wolfarth; Pawel Zalewski; Uta Behrends; Carmen Scheibenbogen

doi:10.1016/j.autrev.2023.103452

Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Sophie Steiner, Annick Fehrer, Friederike Hoheisel^*, Simon Schoening, Anna Aschenbrenner, Nina Babel, Judith Bellmann-Strobl, Carsten Finke, Øystein Fluge, Laura Froehlich, Andreas Goebel, Bettina Grande, Johannes Peter Haas, Bettina Hohberger, Leonard A. Jason, Anthony L. Komaroff, Eliana Lacerda, Max Liebl, Andrea Maier, Olav MellaLuis Nacul, Friedemann Paul, Bhupesh K. Prusty, Christian Puta, Gabriela Riemekasten, Wolfgang Ries, Peter C. Rowe, Birgit Sawitzki, Yehuda Shoenfeld, Joachim L. Schultze, Martina Seifert, Nuno Sepúlveda, Franziska Sotzny, Elisa Stein, Michael Stingl, Friederike Ufer, Christian Veauthier, Francisco Westermeier, Klaus Wirth, Bernd Wolfarth, Pawel Zalewski, Uta Behrends, Carmen Scheibenbogen

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Rheumatologie und klinische Immunologie

19 Zitate (Scopus)

Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charité Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.

Originalsprache	Englisch
Aufsatznummer	103452
Zeitschrift	Autoimmunity Reviews
Jahrgang	22
Ausgabenummer	11
ISSN	1568-9972
DOIs	https://doi.org/10.1016/j.autrev.2023.103452
Publikationsstatus	Veröffentlicht - 11.2023

Fördermittel

We would like to thank the ME/CFS Research Foundation and Joerg Heydecke for organizing and funding the symposium as well as the Weidenhammer-Zoebele Foundation for funding and continuous support. Moreover, we thank Sabine Pabst for her great effort in organizing the conference as well as Sandra Bauer, Helma Freitag, and Cornelia Heindrich for their support. Carmen Scheibenbogen receives funding from the Weidenhammer Zoebele Foundation, Lost Voices Foundation, Fatigatio e.V., the German Research Foundation (DFG), the German Ministries of Education and Science (BMBF) and Health (BMG). Bettina Hohberger receives funding from the German Ministries of Education and Science (BMBF) and the Bavarian Health and Food Safety Authority (LGL). Bhupesh Prusty receives funding from the Fatigatio e.V., the German Research Foundation (DFG), the German Ministries of Education and Science (BMBF), Amar Foundation, USA, and ME Research UK and Gordon Parish Charitable Trust, UK. Francisco Westermeier receives funding from ME Research UK (SCIO charity number SC036942) and The Solve ME/CFS Initiative (Solve M.E.). Luis Nacul is partially funded by grants from BC Women's Health Foundation, BCCDC Foundation for Population and Public Health, Canada, and the National Institutes of Health (NIH), US. Anna Aschenbrenner is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) via grant #458854699. Joachim Schultze is supported by the DFG via the GRK2168 – #272482170 and by the BMBF via iTREAT (01ZX2202B). Anna Aschenbrenner and Joachim Schultze are members of the excellence cluster ImmunoSensation (EXC 2151) funded by the German Research Foundation (DFG) under grant agreement #390873048 and are supported by the DFG via the SFB 1454 – project number #432325352; grant #466168337; grant #466168626; the BMBF-funded project IMMME (01EJ2204D); and the EU-funded projects ImmunoSep (#847422) and NEUROCOV (#101057775). Uta Behrends receives funding from the Weidenhammer Zoebele Foundation, Lost Voices Foundation, Fatigatio e.V., the German Ministries of Education and Science (BMBF) and Health (BMG) as well as the Bavarian Ministries of Science and Arts (StMWK) and Health and Care (StMGP).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

DFG-Fachsystematik

2.22-18 Rheumatologie
2.21-05 Immunologie

KDSF-Klassifikation für Forschungsfelder

841 - Prävention von Krankheiten
530 - Therapie und Heilung

Dokumente

10.1016/j.autrev.2023.103452

Weitere Links

Link to publication in Scopus

Fingerprint

Untersuchen Sie die Forschungsthemen von „Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center“. Zusammen bilden sie einen einzigartigen Fingerprint.

IMMME - IMMME - Aufklärung der immunologischen Pathomechanismen des postinfektiösen Chronischen Fatigue Syndroms (ME/CFS) - Regulatorische Autoantikörper in der Immunzell- und Vaskulärdysregulation: Biomarker in ME/CFS Subentitäten and Therapieansprechen, Teilprojekt: Regulatorische Autoantikörper in der Immunzell- und Vaskulärdysregulation: Biomarker in ME/CFS Subentitäten and Therapieansprechen
Riemekasten, G. (Projektleiter*in (PI))
01.08.22 → 30.09.25
Projekt: Projekte aus Bundesmitteln › Projekte aus Bundesmitteln: BMFTR (Forschung, Technologie und Raumfahrt)

Zitieren

Steiner, S., Fehrer, A., Hoheisel, F., Schoening, S., Aschenbrenner, A., Babel, N., Bellmann-Strobl, J., Finke, C., Fluge, Ø., Froehlich, L., Goebel, A., Grande, B., Haas, J. P., Hohberger, B., Jason, L. A., Komaroff, A. L., Lacerda, E., Liebl, M., Maier, A., ... Scheibenbogen, C. (2023). Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center. Autoimmunity Reviews, 22(11), Artikel 103452. https://doi.org/10.1016/j.autrev.2023.103452

@article{4413a0342121460aad705e4cd05014f7,

title = "Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charit{\'e} Fatigue Center",

abstract = "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charit{\'e} Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.",

author = "Sophie Steiner and Annick Fehrer and Friederike Hoheisel and Simon Schoening and Anna Aschenbrenner and Nina Babel and Judith Bellmann-Strobl and Carsten Finke and {\O}ystein Fluge and Laura Froehlich and Andreas Goebel and Bettina Grande and Haas, \{Johannes Peter\} and Bettina Hohberger and Jason, \{Leonard A.\} and Komaroff, \{Anthony L.\} and Eliana Lacerda and Max Liebl and Andrea Maier and Olav Mella and Luis Nacul and Friedemann Paul and Prusty, \{Bhupesh K.\} and Christian Puta and Gabriela Riemekasten and Wolfgang Ries and Rowe, \{Peter C.\} and Birgit Sawitzki and Yehuda Shoenfeld and Schultze, \{Joachim L.\} and Martina Seifert and Nuno Sep{\'u}lveda and Franziska Sotzny and Elisa Stein and Michael Stingl and Friederike Ufer and Christian Veauthier and Francisco Westermeier and Klaus Wirth and Bernd Wolfarth and Pawel Zalewski and Uta Behrends and Carmen Scheibenbogen",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

doi = "10.1016/j.autrev.2023.103452",

language = "English",

volume = "22",

journal = "Autoimmunity Reviews",

issn = "1568-9972",

publisher = "Elsevier B.V.",

number = "11",

}

Steiner, S, Fehrer, A, Hoheisel, F, Schoening, S, Aschenbrenner, A, Babel, N, Bellmann-Strobl, J, Finke, C, Fluge, Ø, Froehlich, L, Goebel, A, Grande, B, Haas, JP, Hohberger, B, Jason, LA, Komaroff, AL, Lacerda, E, Liebl, M, Maier, A, Mella, O, Nacul, L, Paul, F, Prusty, BK, Puta, C, Riemekasten, G, Ries, W, Rowe, PC, Sawitzki, B, Shoenfeld, Y, Schultze, JL, Seifert, M, Sepúlveda, N, Sotzny, F, Stein, E, Stingl, M, Ufer, F, Veauthier, C, Westermeier, F, Wirth, K, Wolfarth, B, Zalewski, P, Behrends, U & Scheibenbogen, C 2023, 'Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center', Autoimmunity Reviews, Jg. 22, Nr. 11, 103452. https://doi.org/10.1016/j.autrev.2023.103452

Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center. / Steiner, Sophie; Fehrer, Annick; Hoheisel, Friederike et al.
in: Autoimmunity Reviews, Jahrgang 22, Nr. 11, 103452, 11.2023.

Publikation: Beiträge in Fachzeitschriften › Übersichtsarbeiten › Forschung

TY - JOUR

T1 - Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art

T2 - Report of the 2nd international meeting at the Charité Fatigue Center

AU - Steiner, Sophie

AU - Fehrer, Annick

AU - Hoheisel, Friederike

AU - Schoening, Simon

AU - Aschenbrenner, Anna

AU - Babel, Nina

AU - Bellmann-Strobl, Judith

AU - Finke, Carsten

AU - Fluge, Øystein

AU - Froehlich, Laura

AU - Goebel, Andreas

AU - Grande, Bettina

AU - Haas, Johannes Peter

AU - Hohberger, Bettina

AU - Jason, Leonard A.

AU - Komaroff, Anthony L.

AU - Lacerda, Eliana

AU - Liebl, Max

AU - Maier, Andrea

AU - Mella, Olav

AU - Nacul, Luis

AU - Paul, Friedemann

AU - Prusty, Bhupesh K.

AU - Puta, Christian

AU - Riemekasten, Gabriela

AU - Ries, Wolfgang

AU - Rowe, Peter C.

AU - Sawitzki, Birgit

AU - Shoenfeld, Yehuda

AU - Schultze, Joachim L.

AU - Seifert, Martina

AU - Sepúlveda, Nuno

AU - Sotzny, Franziska

AU - Stein, Elisa

AU - Stingl, Michael

AU - Ufer, Friederike

AU - Veauthier, Christian

AU - Westermeier, Francisco

AU - Wirth, Klaus

AU - Wolfarth, Bernd

AU - Zalewski, Pawel

AU - Behrends, Uta

AU - Scheibenbogen, Carmen

PY - 2023/11

Y1 - 2023/11

N2 - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charité Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.

AB - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charité Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.

UR - https://www.scopus.com/pages/publications/85173184115

U2 - 10.1016/j.autrev.2023.103452

DO - 10.1016/j.autrev.2023.103452

M3 - Scientific review articles

C2 - 37742748

AN - SCOPUS:85173184115

SN - 1568-9972

VL - 22

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 11

M1 - 103452

ER -

Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

KDSF-Klassifikation für Forschungsfelder

Dokumente

Weitere Links

Fingerprint

Projekte

Zitieren