Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

for the German Neonatal Network (GNN)

doi:10.1007/s00431-020-03572-0

Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

for the German Neonatal Network (GNN)

Klinik für Kinder- und Jugendmedizin

47 Zitate (Scopus)

Abstract

Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.

Originalsprache	Englisch
Zeitschrift	European Journal of Pediatrics
Jahrgang	179
Ausgabenummer	8
Seiten (von - bis)	1309-1313
Seitenumfang	5
ISSN	0340-6199
DOIs	https://doi.org/10.1007/s00431-020-03572-0
Publikationsstatus	Veröffentlicht - 01.08.2020

Fördermittel

We are grateful for the support of the families and of the colleagues contributing to this network. Egbert Herting, Angela Kribs, Christoph H?rtel, Bernhard Roth and Wolfgang G?pel designed the AMV study originally. Egbert Herting, Angela Kribs, Christoph H?rtel, Axel von der Wense, Ursula Weller, Thomas Hoehn, Matthias Vochem, Jens M?ller, Christian Wieg, Bernhard Roth and Wolfgang G?pel were actively involved in the data collection for the follow-up at 2?years. The first draft of the manuscript was written by Egbert Herting and Wolfgang G?pel. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 5 – Gender Equality

Dokumente

10.1007/s00431-020-03572-0

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@article{7ad8ff144e034ae5bc9885a7c1e67133,

title = "Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study",

abstract = "Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.",

author = "\{for the German Neonatal Network (GNN)\} and Egbert Herting and Angela Kribs and Christoph H{\"a}rtel and \{von der Wense\}, Axel and Ursula Weller and Thomas Hoehn and Matthias Vochem and Jens M{\"o}ller and Christian Wieg and Bernhard Roth and Wolfgang G{\"o}pel",

note = "Funding Information: We are grateful for the support of the families and of the colleagues contributing to this network. Egbert Herting, Angela Kribs, Christoph H?rtel, Bernhard Roth and Wolfgang G?pel designed the AMV study originally. Egbert Herting, Angela Kribs, Christoph H?rtel, Axel von der Wense, Ursula Weller, Thomas Hoehn, Matthias Vochem, Jens M?ller, Christian Wieg, Bernhard Roth and Wolfgang G?pel were actively involved in the data collection for the follow-up at 2?years. The first draft of the manuscript was written by Egbert Herting and Wolfgang G?pel. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. Publisher Copyright: {\textcopyright} 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = aug,

day = "1",

doi = "10.1007/s00431-020-03572-0",

language = "English",

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Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study. / for the German Neonatal Network (GNN).
in: European Journal of Pediatrics, Jahrgang 179, Nr. 8, 01.08.2020, S. 1309-1313.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

AU - for the German Neonatal Network (GNN)

AU - Herting, Egbert

AU - Kribs, Angela

AU - Härtel, Christoph

AU - von der Wense, Axel

AU - Weller, Ursula

AU - Hoehn, Thomas

AU - Vochem, Matthias

AU - Möller, Jens

AU - Wieg, Christian

AU - Roth, Bernhard

AU - Göpel, Wolfgang

N1 - Funding Information: We are grateful for the support of the families and of the colleagues contributing to this network. Egbert Herting, Angela Kribs, Christoph H?rtel, Bernhard Roth and Wolfgang G?pel designed the AMV study originally. Egbert Herting, Angela Kribs, Christoph H?rtel, Axel von der Wense, Ursula Weller, Thomas Hoehn, Matthias Vochem, Jens M?ller, Christian Wieg, Bernhard Roth and Wolfgang G?pel were actively involved in the data collection for the follow-up at 2?years. The first draft of the manuscript was written by Egbert Herting and Wolfgang G?pel. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. Publisher Copyright: © 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.

AB - Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.

UR - https://www.scopus.com/pages/publications/85079719058

U2 - 10.1007/s00431-020-03572-0

DO - 10.1007/s00431-020-03572-0

M3 - Journal articles

C2 - 32067100

AN - SCOPUS:85079719058

SN - 0340-6199

VL - 179

SP - 1309

EP - 1313

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

IS - 8

ER -