Tumor-specific glycosylation of the carcinoma-associated epithelial cell adhesion molecule EpCAM in head and neck carcinomas

Christof Pauli, Markus Münz, Cuong Kieu, Brigitte Mack, Peter Breinl, Barbara Wollenberg, Stephan Lang, Reinhard Zeidler, Olivier Gires*

*Korrespondierende/r Autor/-in für diese Arbeit
69 Zitate (Scopus)

Abstract

The tissue-specific glycosylation of the carcinoma (CA)-associated antigen epithelial cell adhesion molecule (EpCAM) was studied in 60 patients suffering from head and neck CAs, and 26 pairs of autologous healthy thyroid and CA biopsies. EpCAM was glycosylated in all tumor samples in which its expression was detectable (73%). Additionally, in 80.7% of patients, tumor-derived EpCAM was heavily glycosylated while EpCAM derived from autologous thyroid was not (76.2%) or weakly (23.8%). Four cases showed a similar glycosylation pattern (15.3%) and one case displayed a reverse pattern (3.8%). Additionally, the expression and glycosylation of EpCAM were assessed in tumor adjacent and distant tissue. EpCAM was glycosylated in tumor-adjacent while it was not or only weakly expressed in tumor distant tissue where it was unglycosylated. Thus, EpCAM is differentially glycosylated in healthy tissue and tumor cells of the head and neck area.

OriginalspracheEnglisch
ZeitschriftCancer Letters
Jahrgang193
Ausgabenummer1
Seiten (von - bis)25-32
Seitenumfang8
ISSN0304-3835
DOIs
PublikationsstatusVeröffentlicht - 10.04.2003

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