Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism

S. Paus; F. Gadow; O. Kaut; M. Knapp; C. Klein; T. Klockgether; U. Wüllner

doi:10.1016/j.parkreldis.2010.03.006

Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism

S. Paus^*, F. Gadow, O. Kaut, M. Knapp, C. Klein, T. Klockgether, U. Wüllner

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Neurogenetik

8 Zitate (Scopus)

Abstract

A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D₃ receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.

Originalsprache	Englisch
Zeitschrift	Parkinsonism and Related Disorders
Jahrgang	16
Ausgabenummer	6
Seiten (von - bis)	381-383
Seitenumfang	3
ISSN	1353-8020
DOIs	https://doi.org/10.1016/j.parkreldis.2010.03.006
Publikationsstatus	Veröffentlicht - 01.07.2010

Fördermittel

This study was supported by the Federal Ministry of Education and Research , the German Competence Network on Parkinson’s disease ( 01G19901, 01GI0201, 01GI0401 ), the Hans-Tauber-Stiftung of the German Parkinson Association, NGFN ( 01GS0115, NV-SO2T9 ), and the BONFOR Program of the University of Bonn (UW). CK is supported by a Lichtenberg Grant from the Volkswagen Foundation and a career development award from the Hermann and Lilly Schilling Foundation. Patients who agreed to participate in the CNP gene bank were recruited from: Bad Nauheim (M. Schmidt), Bad Neustadt (M. Hahne), Berlin (D. Gruber), Bochum (J. Jamorzy), Bremerhaven (P. Odin), Dresden (S. Junghanns, U. Sommer), Düsseldorf (L. Timmermann, L. Wojtecki, R. Moosbauer), Freiburg (L. Wiese), Göttingen (T. Tings), Hamburg (U. Hidding, K. Hinkelmann, L. Kohlbrecher), Hanau (C. Weiland, C. Gensch, L. Meisemann), Hannover (C. Schrader), Heidelberg (M. Kloβ), Kassel (M. Morelli), Kiel (A. Seils, K. Dagvadorj, S. Klebe), Homburg (G. Fuβ), Lemgo (P. Vieregge), Lübeck (J. Hagenah, M. Kasten, S. Maniak, S. Hauenschild), Marburg (S. Lazer, I. Ferenczy, V. Mylius, D. Lang-Pfeiffer, A. Metz, D. Niewerth, A. Becker, M. Paukner), München (S. Maaβ, F. Asmus), Rostock (A. Wolters, G. Zegowitz), Tübingen (J. Prestel, T. Dehmer, T. Gasser), and Wiesbaden (W. Jost, M. Humann).

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title = "Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism",

abstract = "A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D3 receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.",

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AU - Paus, S.

AU - Gadow, F.

AU - Kaut, O.

AU - Knapp, M.

AU - Klein, C.

AU - Klockgether, T.

AU - Wüllner, U.

PY - 2010/7/1

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N2 - A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D3 receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.

AB - A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D3 receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.

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DO - 10.1016/j.parkreldis.2010.03.006

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Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism

Abstract

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