Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

A. Sprenger; H. Rambold; T. Sander; S. Marti; K. Weber; D. Straumann; C. Helmchen

doi:10.1212/01.wnl.0000233829.76150.6b

Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

A. Sprenger, H. Rambold, T. Sander, S. Marti, K. Weber, D. Straumann, C. Helmchen^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Neurologie

21 Zitate (Scopus)

Abstract

The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.

Originalsprache	Englisch
Zeitschrift	Neurology
Jahrgang	67
Ausgabenummer	5
Seiten (von - bis)	905-907
Seitenumfang	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/01.wnl.0000233829.76150.6b
Publikationsstatus	Veröffentlicht - 01.01.2006

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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AU - Sprenger, A.

AU - Rambold, H.

AU - Sander, T.

AU - Marti, S.

AU - Weber, K.

AU - Straumann, D.

AU - Helmchen, C.

PY - 2006/1/1

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AB - The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.

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JO - Neurology

JF - Neurology

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Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

Abstract

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