Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model

Jan Rupp; Marcus Koch; Ger Van Zandbergen; Werner Solbach; Ernst Brandt; Matthias Maass

doi:10.1016/j.femsle.2004.11.010

Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model

Jan Rupp, Marcus Koch, Ger Van Zandbergen, Werner Solbach, Ernst Brandt, Matthias Maass

Leibniz Forschungszentrum Borstel

19 Zitate (Scopus)

Abstract

Chlamydia pneumoniae uses blood monocytes (PBMC) for systemic dissemination, persists in atherosclerotic lesions, and has been implicated in the pathogenesis of atherosclerosis. During transmigration in a newly developed transendothelial migration model (TEM) C. pneumoniae-infected PBMC spread their infection to endothelial cells. Transmigrated PBMC retained their infectivity and transmitted the pathogen to smooth muscle cells in the lower chamber of the TEM. Detection of chlamydial HSP60 mRNA proved pathogen viability and virulence. We conclude that PBMC can spread chlamydial infection to vascular wall cells and we suggest the TEM as a novel tool to analyze host-pathogen interactions in vascular chlamydial infections.

Originalsprache	Englisch
Zeitschrift	FEMS Microbiology Letters
Jahrgang	242
Ausgabenummer	2
Seiten (von - bis)	203-208
Seitenumfang	6
ISSN	0378-1097
DOIs	https://doi.org/10.1016/j.femsle.2004.11.010
Publikationsstatus	Veröffentlicht - 15.01.2005

Fördermittel

This study was supported by a grant from the Deutsche Forschungsgemeinschaft (SFB 367/ B11 and SPP1130, Ma2070/4-1). We gratefully thank T. Luedemann, A. Hellberg and A. Gravenhorst (University of Luebeck) for technical assistance.

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Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1016/j.femsle.2004.11.010

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title = "Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model",

abstract = "Chlamydia pneumoniae uses blood monocytes (PBMC) for systemic dissemination, persists in atherosclerotic lesions, and has been implicated in the pathogenesis of atherosclerosis. During transmigration in a newly developed transendothelial migration model (TEM) C. pneumoniae-infected PBMC spread their infection to endothelial cells. Transmigrated PBMC retained their infectivity and transmitted the pathogen to smooth muscle cells in the lower chamber of the TEM. Detection of chlamydial HSP60 mRNA proved pathogen viability and virulence. We conclude that PBMC can spread chlamydial infection to vascular wall cells and we suggest the TEM as a novel tool to analyze host-pathogen interactions in vascular chlamydial infections.",

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doi = "10.1016/j.femsle.2004.11.010",

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AU - Rupp, Jan

AU - Koch, Marcus

AU - Van Zandbergen, Ger

AU - Solbach, Werner

AU - Brandt, Ernst

AU - Maass, Matthias

PY - 2005/1/15

Y1 - 2005/1/15

N2 - Chlamydia pneumoniae uses blood monocytes (PBMC) for systemic dissemination, persists in atherosclerotic lesions, and has been implicated in the pathogenesis of atherosclerosis. During transmigration in a newly developed transendothelial migration model (TEM) C. pneumoniae-infected PBMC spread their infection to endothelial cells. Transmigrated PBMC retained their infectivity and transmitted the pathogen to smooth muscle cells in the lower chamber of the TEM. Detection of chlamydial HSP60 mRNA proved pathogen viability and virulence. We conclude that PBMC can spread chlamydial infection to vascular wall cells and we suggest the TEM as a novel tool to analyze host-pathogen interactions in vascular chlamydial infections.

AB - Chlamydia pneumoniae uses blood monocytes (PBMC) for systemic dissemination, persists in atherosclerotic lesions, and has been implicated in the pathogenesis of atherosclerosis. During transmigration in a newly developed transendothelial migration model (TEM) C. pneumoniae-infected PBMC spread their infection to endothelial cells. Transmigrated PBMC retained their infectivity and transmitted the pathogen to smooth muscle cells in the lower chamber of the TEM. Detection of chlamydial HSP60 mRNA proved pathogen viability and virulence. We conclude that PBMC can spread chlamydial infection to vascular wall cells and we suggest the TEM as a novel tool to analyze host-pathogen interactions in vascular chlamydial infections.

UR - https://www.scopus.com/pages/publications/11144259435

U2 - 10.1016/j.femsle.2004.11.010

DO - 10.1016/j.femsle.2004.11.010

M3 - Journal articles

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AN - SCOPUS:11144259435

SN - 0378-1097

VL - 242

SP - 203

EP - 208

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 2

ER -

Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model

Abstract

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