Abstract
Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.
| Originalsprache | Englisch |
|---|---|
| Zeitschrift | Parkinsonism and Related Disorders |
| Jahrgang | 79 |
| Seiten (von - bis) | 88-90 |
| Seitenumfang | 3 |
| ISSN | 1353-8020 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 01.10.2020 |
Fördermittel
Ana Westenberger is funded by the Deutsche Forschungsgemeinschaft (FOR2488) and serves as a consultant for medical writing at Centogene AG. Christine Klein is an associate editor of Annals of Neurology. She serves as a medical advisor to Centogene AG for medical advice on genetic testing reports in the fields of movement disorders and dementia, excluding Parkinson's disease. She is funded by the Deutsche Forschungsgemeinschaft ( FOR 2488 ), the European Union , and received institutional support from the University of Lübeck for genetics research.
UN SDGs
Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung
-
SDG 3 – Gesundheit und Wohlergehen -
SDG 10 – Weniger Ungleichheiten
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
Fingerprint
Untersuchen Sie die Forschungsthemen von „Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model“. Zusammen bilden sie einen einzigartigen Fingerprint.Zitieren
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver