Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model

D. Alvarez-Fischer; T. Vernik; F. Vulinovic; A. Herrmann; A. Westenberger; C. Klein

doi:10.1016/j.parkreldis.2020.08.017

Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model

D. Alvarez-Fischer^*, T. Vernik, F. Vulinovic, A. Herrmann, A. Westenberger, C. Klein

^*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.

Originalsprache	Englisch
Zeitschrift	Parkinsonism and Related Disorders
Jahrgang	79
Seiten (von - bis)	88-90
Seitenumfang	3
ISSN	1353-8020
DOIs	https://doi.org/10.1016/j.parkreldis.2020.08.017
Publikationsstatus	Veröffentlicht - 01.10.2020

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.parkreldis.2020.08.017

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AU - Alvarez-Fischer, D.

AU - Vernik, T.

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AU - Westenberger, A.

AU - Klein, C.

PY - 2020/10/1

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N2 - Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.

AB - Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.

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Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model

Abstract

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