Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin

Joerg Wenzel*, Stefan Tomiuk, Sabine Zahn, Daniel Küsters, Anja Vahsen, Andreas Wiechert, Sandra Mikus, Michael Birth, Marina Scheler, Dagmar Von Bubnoff, Jens M. Baron, Hans F. Merk, Cornelia Mauch, Thomas Krieg, Thomas Bieber, Andreas Bosio, Kay Hofmann, Thomas Tüting, Bettina Peters

*Korrespondierende/r Autor/-in für diese Arbeit
21 Zitate (Scopus)

Abstract

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) represent the 2 most common types of nonmelanoma skin cancer. Both derive from keratinocytes but show a distinct biological behavior. Here we present transcriptional profiling data of a large cohort of tumor patients (SCC, = 5 42; BCC, n = 114). Differentially expressed genes reflect known features of SCC and BCC including the typical cytokeratin pattern as well as upregulation of characteristic cell proliferation genes. Additionally, we found increased expression of interferon (IFN)-regulated genes (including IFI27, IFI30, Mx1, IRF1 and CXCL9) in SCC, and to a lower extent in BCC. The expression of IFN-regulated genes correlated with the extent of the lesional immune-cell infiltrate. Immunohistological examinations confirmed the expression of IFN-regulated genes in association with a CXCR3+ cytotoxic inflammatory infiltrate on the protein level. Of note, a small subset of SCC samples with low expression of IFN-regulated genes included most organ transplant recipients receiving immunosuppressive medication. Collectively, our findings support the concept that IFN-associated host responses play an important role in tumor immunosurveillance in the skin.

OriginalspracheEnglisch
ZeitschriftInternational Journal of Cancer
Jahrgang123
Ausgabenummer11
Seiten (von - bis)2605-2615
Seitenumfang11
ISSN0020-7136
DOIs
PublikationsstatusVeröffentlicht - 01.12.2008

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