Transcranial sonography as early indicator for genetic Parkinson's disease

Christian Kier; Günter Seidel; Norbert Brüggemann; Johann Hagenah; Christine Klein; Til Aach; Alfred Mertins

doi:10.1007/978-3-540-89208-3_108

Transcranial sonography as early indicator for genetic Parkinson's disease

Christian Kier, Günter Seidel, Norbert Brüggemann, Johann Hagenah, Christine Klein, Til Aach, Alfred Mertins

Abstract

Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.

Originalsprache	Englisch
Titel	4th European Conference of the International Federation for Medical and Biological Engineering
Redakteure/-innen	Jos Vander Sloten, Pascal Verdonck, Marc Nyssen, Jens Haueisen
Seitenumfang	4
Band	22
Erscheinungsort	Berlin, Heidelberg
Herausgeber (Verlag)	Springer Berlin Heidelberg
Erscheinungsdatum	01.11.2009
Seiten	456-459
ISBN (Print)	978-3-540-89207-6
ISBN (elektronisch)	978-3-540-89208-3
DOIs	https://doi.org/10.1007/978-3-540-89208-3_108
Publikationsstatus	Veröffentlicht - 01.11.2009
Veranstaltung	4th European Conference of the International Federation for Medical and Biological Engineering - Antwerp, Belgien Dauer: 23.11.2008 → 27.11.2008 Konferenznummer: 81647

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10.1007/978-3-540-89208-3_108

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https://www.scopus.com/pages/publications/70350637677

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Kier, C., Seidel, G., Brüggemann, N., Hagenah, J., Klein, C., Aach, T., & Mertins, A. (2009). Transcranial sonography as early indicator for genetic Parkinson's disease. in J. Vander Sloten, P. Verdonck, M. Nyssen, & J. Haueisen (Hrsg.), 4th European Conference of the International Federation for Medical and Biological Engineering (Band 22, S. 456-459). ( IFMBE Proceedings; Band 22). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_108

Kier, Christian ; Seidel, Günter ; Brüggemann, Norbert et al. / Transcranial sonography as early indicator for genetic Parkinson's disease. 4th European Conference of the International Federation for Medical and Biological Engineering. Hrsg. / Jos Vander Sloten ; Pascal Verdonck ; Marc Nyssen ; Jens Haueisen. Band 22 Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. S. 456-459 ( IFMBE Proceedings).

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title = "Transcranial sonography as early indicator for genetic Parkinson's disease",

abstract = "Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90\% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.",

author = "Christian Kier and G{\"u}nter Seidel and Norbert Br{\"u}ggemann and Johann Hagenah and Christine Klein and Til Aach and Alfred Mertins",

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doi = "10.1007/978-3-540-89208-3\_108",

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Kier, C, Seidel, G, Brüggemann, N, Hagenah, J, Klein, C, Aach, T & Mertins, A 2009, Transcranial sonography as early indicator for genetic Parkinson's disease. in J Vander Sloten, P Verdonck, M Nyssen & J Haueisen (Hrsg.), 4th European Conference of the International Federation for Medical and Biological Engineering. Bd. 22, IFMBE Proceedings, Bd. 22, Springer Berlin Heidelberg, Berlin, Heidelberg, S. 456-459, 4th European Conference of the International Federation for Medical and Biological Engineering, Antwerp, Belgien, 23.11.08. https://doi.org/10.1007/978-3-540-89208-3_108

Transcranial sonography as early indicator for genetic Parkinson's disease. / Kier, Christian; Seidel, Günter; Brüggemann, Norbert et al.
4th European Conference of the International Federation for Medical and Biological Engineering. Hrsg. / Jos Vander Sloten; Pascal Verdonck; Marc Nyssen; Jens Haueisen. Band 22 Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. S. 456-459 ( IFMBE Proceedings; Band 22).

Publikation: Kapitel in Büchern/Berichten/Konferenzbänden › Konferenzbeitrag › Begutachtung

TY - GEN

T1 - Transcranial sonography as early indicator for genetic Parkinson's disease

AU - Kier, Christian

AU - Seidel, Günter

AU - Brüggemann, Norbert

AU - Hagenah, Johann

AU - Klein, Christine

AU - Aach, Til

AU - Mertins, Alfred

N1 - Conference code: 81647

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.

AB - Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.

UR - https://www.scopus.com/pages/publications/70350637677

U2 - 10.1007/978-3-540-89208-3_108

DO - 10.1007/978-3-540-89208-3_108

M3 - Conference contribution

SN - 978-3-540-89207-6

VL - 22

T3 - IFMBE Proceedings

SP - 456

EP - 459

BT - 4th European Conference of the International Federation for Medical and Biological Engineering

A2 - Vander Sloten, Jos

A2 - Verdonck, Pascal

A2 - Nyssen, Marc

A2 - Haueisen, Jens

PB - Springer Berlin Heidelberg

CY - Berlin, Heidelberg

T2 - 4th European Conference of the International Federation for Medical and Biological Engineering

Y2 - 23 November 2008 through 27 November 2008

ER -

Kier C, Seidel G, Brüggemann N, Hagenah J, Klein C, Aach T et al. Transcranial sonography as early indicator for genetic Parkinson's disease. in Vander Sloten J, Verdonck P, Nyssen M, Haueisen J, Hrsg., 4th European Conference of the International Federation for Medical and Biological Engineering. Band 22. Berlin, Heidelberg: Springer Berlin Heidelberg. 2009. S. 456-459. ( IFMBE Proceedings). doi: 10.1007/978-3-540-89208-3_108

Transcranial sonography as early indicator for genetic Parkinson's disease

Abstract

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