Transcranial sonography as early indicator for genetic Parkinson's disease

Abstract

Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.
OriginalspracheEnglisch
Titel4th European Conference of the International Federation for Medical and Biological Engineering
Redakteure/-innenJos Vander Sloten, Pascal Verdonck, Marc Nyssen, Jens Haueisen
Seitenumfang4
Band22
ErscheinungsortBerlin, Heidelberg
Herausgeber (Verlag)Springer Berlin Heidelberg
Erscheinungsdatum01.11.2009
Seiten456-459
ISBN (Print)978-3-540-89207-6
ISBN (elektronisch)978-3-540-89208-3
DOIs
PublikationsstatusVeröffentlicht - 01.11.2009
Veranstaltung4th European Conference of the International Federation for Medical and Biological Engineering - Antwerp, Belgien
Dauer: 23.11.200827.11.2008
Konferenznummer: 81647

Fingerprint

Untersuchen Sie die Forschungsthemen von „Transcranial sonography as early indicator for genetic Parkinson's disease“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren