TY - JOUR
T1 - Tissue microarrays: Applications in urological cancer research
AU - Merseburger, A. S.
AU - Anastasiadis, A. G.
AU - Hennenlotter, J.
AU - Schilling, D.
AU - Simon, P.
AU - Machtens, S. A.
AU - Serth, J.
AU - Stenzl, Arnulf
AU - Kuczyk, Markus A.
N1 - Funding Information:
Acknowledgments Supported by a grant from the Federal Ministry of Education and Research (Fö. 01KS9602) and the Interdisciplinary Center of Clinical Research Tübingen (IZKF). Dr Merseburger is supported by a postgraduate grant from the Novartis Foundation.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/11
Y1 - 2006/11
N2 - Tissue microarrays (TMAs) are used to simultaneously study the expression of proteins in hundreds of tissue samples, offering the important advantage to screen large tissue banks for biomarker expression and to simultaneously examine serial sections obtained from the same tumor specimen by a time- and cost-effective analytical approach. This review article presents an overview of the importance and the impact of this technique in cancer research with increasing number of investigations using TMAs in its eighth anniversary. Its application, limitations, and selected previous study results regarding urologic malignancies are presented and discussed.
AB - Tissue microarrays (TMAs) are used to simultaneously study the expression of proteins in hundreds of tissue samples, offering the important advantage to screen large tissue banks for biomarker expression and to simultaneously examine serial sections obtained from the same tumor specimen by a time- and cost-effective analytical approach. This review article presents an overview of the importance and the impact of this technique in cancer research with increasing number of investigations using TMAs in its eighth anniversary. Its application, limitations, and selected previous study results regarding urologic malignancies are presented and discussed.
UR - http://www.scopus.com/inward/record.url?scp=33751238817&partnerID=8YFLogxK
U2 - 10.1007/s00345-006-0103-1
DO - 10.1007/s00345-006-0103-1
M3 - Scientific review articles
C2 - 16896596
AN - SCOPUS:33751238817
SN - 0724-4983
VL - 24
SP - 579
EP - 584
JO - World Journal of Urology
JF - World Journal of Urology
IS - 5
ER -
