TY - JOUR
T1 - Tissue fatty acid composition in obstructive sleep apnea and recurrent tonsillitis
AU - Ezzedini, Rana
AU - Darabi, Maryam
AU - Ghasemi, Babollah
AU - Darabi, Masoud
AU - Fayezi, Shabnam
AU - Moghaddam, Yalda Jabbari
AU - Mehdizadeh, Amir
AU - Abdollahi, Shahin
AU - Gharahdaghi, Abasaad
N1 - Funding Information:
The research was supported by a grant to M.D. (89-21 from the Tuberculosis and Lung Research Center of Tabriz University of Medical Sciences ). This study was conducted as part of a Master's thesis project no. 90/7 at the Tabriz University of Medical Sciences for the R.E. under the supervision of M.D.
PY - 2013/6
Y1 - 2013/6
N2 - Objective: Tonsillar hypertrophy cells appear to have an altered lipid metabolism as evidenced by modulated inflammatory cytokines that affect tissue lipid metabolism. The aim of this study was to investigate differences in tissue fat composition between obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Tonsillar tissues were collected from 114 patients with OSA and 92 patients with RT, aged 4-10 years, during tonsillectomy. The tissue lipid extracts were analyzed by gas liquid chromatography for a comprehensive fatty acid profile. Results: In the tonsillitis tissue, the levels of palmitoleic acid (16:1. n-7; P = 0.002) and oleic acid (18:1. n-9; P = 0.003) were higher, and the level of stearic acid (18:0; P = 0.004) was lower than that in the hyperplastic tonsillar tissue. Overall, tonsillar tissue of patients with RT had a significant increase in the total monounsaturated fatty acids (+9.9%; P < 0.001) and the fatty acid desaturation index (+20.5%; P < 0.001). Furthermore, oleic acid content of tonsillar tissue was positively correlated with BMI (r = 0.20, P = 0.004), snoring (r=0.16, P = 0.022) and hypertrophy grade (r = 0.18, P = 0.023), which remain significant in the subgroup analysis by hypertrophy type. Conclusions: The change in the fatty acid composition may be regarded as an indicator of altered lipid metabolism occurring in vivo during human tonsillar hypertrophy, which might be linked to the severity or type of the tissue damage.
AB - Objective: Tonsillar hypertrophy cells appear to have an altered lipid metabolism as evidenced by modulated inflammatory cytokines that affect tissue lipid metabolism. The aim of this study was to investigate differences in tissue fat composition between obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Tonsillar tissues were collected from 114 patients with OSA and 92 patients with RT, aged 4-10 years, during tonsillectomy. The tissue lipid extracts were analyzed by gas liquid chromatography for a comprehensive fatty acid profile. Results: In the tonsillitis tissue, the levels of palmitoleic acid (16:1. n-7; P = 0.002) and oleic acid (18:1. n-9; P = 0.003) were higher, and the level of stearic acid (18:0; P = 0.004) was lower than that in the hyperplastic tonsillar tissue. Overall, tonsillar tissue of patients with RT had a significant increase in the total monounsaturated fatty acids (+9.9%; P < 0.001) and the fatty acid desaturation index (+20.5%; P < 0.001). Furthermore, oleic acid content of tonsillar tissue was positively correlated with BMI (r = 0.20, P = 0.004), snoring (r=0.16, P = 0.022) and hypertrophy grade (r = 0.18, P = 0.023), which remain significant in the subgroup analysis by hypertrophy type. Conclusions: The change in the fatty acid composition may be regarded as an indicator of altered lipid metabolism occurring in vivo during human tonsillar hypertrophy, which might be linked to the severity or type of the tissue damage.
UR - http://www.scopus.com/inward/record.url?scp=84877797689&partnerID=8YFLogxK
U2 - 10.1016/j.ijporl.2013.03.033
DO - 10.1016/j.ijporl.2013.03.033
M3 - Journal articles
C2 - 23643333
AN - SCOPUS:84877797689
SN - 0165-5876
VL - 77
SP - 1008
EP - 1012
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
IS - 6
ER -
