Tippfehler im Genom: erbliche Ursachen von Herzerkrankungen

Coronary artery disease (CAD) and its clinical manifestation myocardial infarction (MI) is the leading cause of death in the western world. Besides environmental factors, genetic factors largely influence the risk of the disease. Recently, several CAD risk loci have been identified. Only one third of these loci influence traditional risk factors as lipid traits and blood pressure. However, two thirds are unforeseen risk loci that may give new insight to the pathomechanism of CAD. The goal of this research field is to reveal new therapeutic targets and enable a stratified treatment.