Thyroid wars: the rise of central actions

Valentina Capelli; Carlos Diéguez; Jens Mittag; Miguel López

doi:10.1016/j.tem.2021.05.006

Thyroid wars: the rise of central actions

Valentina Capelli, Carlos Diéguez, Jens Mittag^*, Miguel López

^*Korrespondierende/r Autor/-in für diese Arbeit

University Santiago de Compostela

25 Zitate (Scopus)

Abstract

In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH ‘central’ metabolic action, which was recently discovered in rodent models and challenged the previous ‘peripheral’ paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.

Originalsprache	Englisch
Zeitschrift	Trends in Endocrinology and Metabolism
Jahrgang	32
Ausgabenummer	9
Seiten (von - bis)	659-671
Seitenumfang	13
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2021.05.006
Publikationsstatus	Veröffentlicht - 09.2021

Fördermittel

The research leading to these results has received funding from the Xunta de Galicia (M.L.: 2016-PG068 ), Ministerio de Economía y Competitividad (MINECO) co-funded by the FEDER Program of the EU (C.D.: BFU2017-87721-P ; M.L.: RTI2018-101840-B-I00 ); the Atresmedia Corporación (M.L.); ‘la Caixa’ Foundation (ID 100010434 ) under the agreement LCF/PR/HR19/52160022 (M.L.); and the German Research Council (DFG) in the framework of the CRC/TR-296 ‘Local Control of Thyroid Hormone Action’ (J.M.). CiMUS is supported by the Xunta de Galicia ( 2016-2019 , ED431G/05 ). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The research leading to these results has received funding from the Xunta de Galicia (M.L.: 2016-PG068), Ministerio de Econom?a y Competitividad (MINECO) co-funded by the FEDER Program of the EU (C.D.: BFU2017-87721-P; M.L.: RTI2018-101840-B-I00); the Atresmedia Corporaci?n (M.L.); ?la Caixa? Foundation (ID 100010434) under the agreement LCF/PR/HR19/52160022 (M.L.); and the German Research Council (DFG) in the framework of the CRC/TR-296 ?Local Control of Thyroid Hormone Action? (J.M.). CiMUS is supported by the Xunta de Galicia (2016-2019, ED431G/05). CIBER de Fisiopatolog?a de la Obesidad y Nutrici?n is an initiative of ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No interests are declared.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

2.22-17 Endokrinologie, Diabetologie, Metabolismus

Dokumente

10.1016/j.tem.2021.05.006

Weitere Links

Link to publication in Scopus

1 Abgeschlossen

SFB/TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung
Führer-Sakel, D. (Sprecher*in), Mittag, J. (Stellv. Sprecher*in, Co-Sprecher*in), Kühnen, P. (Stellv. Sprecher*in, Co-Sprecher*in), Heuer, H. (Projektleiter*in (PI)), Schwaninger, M. (Projektleiter*in (PI)), Müller-Fielitz, H. (Projektleiter*in (PI)), Bechmann, I. (Projektleiter*in (PI)), Biebermann, H. (Projektleiter*in (PI)), Müller, T. (Projektleiter*in (PI)), Pfluger, P. (Projektleiter*in (PI)), Krude, H. (Projektleiter*in (PI)), Schülke-Gerstenfeld, M. (Projektleiter*in (PI)), Cirkel, A. (Projektleiter*in (PI)), Münte, T. (Projektleiter*in (PI)), Kleinschnitz, C. (Projektleiter*in (PI)), Langhauser, F. (Projektleiter*in (PI)), Engel, D. R. (Projektleiter*in (PI)), Möller, L. (Projektleiter*in (PI)), Kaiser, F. (Projektleiter*in (PI)), Oster, H. (Projektleiter*in (PI)), Kirchner, H. (Projektleiter*in (PI)), Spranger, J. (Projektleiter*in (PI)), Tacke, F. (Projektleiter*in (PI)), Wirth, E. K. (Projektleiter*in (PI)), Köhrle, J. (Projektleiter*in (PI)), Schomburg, L. (Projektleiter*in (PI)), Lange, C. M. (Projektleiter*in (PI)), Zwanziger, D. (Projektleiter*in (PI)), Mayerl, S. (Projektleiter*in (PI)), Stachelscheid, H. (Projektleiter*in (PI)), Opitz, R. (Projektleiter*in (PI)), Prasuhn, J. (Projektleiter*in (PI)), Lorenz, K. (Projektleiter*in (PI)), Köster, J. (Projektleiter*in (PI)), Mai, K. (Projektleiter*in (PI)), Püngel, T. (Projektleiter*in (PI)), Obermayer, B. (Projektleiter*in (PI)) & Rehwald, S. (Projektleiter*in (PI))
01.01.20 → 31.12.25
Projekt: DFG Verbundprojekte › DFG Sonderforschungsbereiche / Transregios (SFB/TR)

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abstract = "In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH {\textquoteleft}central{\textquoteright} metabolic action, which was recently discovered in rodent models and challenged the previous {\textquoteleft}peripheral{\textquoteright} paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.",

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Thyroid wars: the rise of central actions

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

Weitere Links

Fingerprint

Projekte

SFB/TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung

Zitieren