Thyroid wars: the rise of central actions

Valentina Capelli; Carlos Diéguez; Jens Mittag; Miguel López

doi:10.1016/j.tem.2021.05.006

Thyroid wars: the rise of central actions

Valentina Capelli, Carlos Diéguez, Jens Mittag^*, Miguel López

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Endokrinologie und Diabetes

13 Zitate (Scopus)

Abstract

In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH ‘central’ metabolic action, which was recently discovered in rodent models and challenged the previous ‘peripheral’ paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.

Originalsprache	Englisch
Zeitschrift	Trends in Endocrinology and Metabolism
Jahrgang	32
Ausgabenummer	9
Seiten (von - bis)	659-671
Seitenumfang	13
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2021.05.006
Publikationsstatus	Veröffentlicht - 09.2021

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

205-17 Endokrinologie, Diabetologie, Metabolismus

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Zugriff auf Dokument

10.1016/j.tem.2021.05.006

Andere Dateien und Links

Link to publication in Scopus

SFB/Transregio TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung
Führer-Sakel, D., Mittag, J., Kühnen, P., Heuer, H., Schwaninger, M., Müller-Fielitz, H., Bechmann, I., Biebermann, H., Müller, T., Pfluger, P., Krude, H., Schülke-Gerstenfeld, M., Cirkel, A., Münte, T., Kleinschnitz, C., Langhauser, F., Engel, D. R., Möller, L., Kaiser, F., Oster, H., Kirchner, H., Spranger, J., Tacke, F., Wirth, E. K., Köhrle, J., Schomburg, L., Lange, C. M., Zwanziger, D., Mayerl, S. & Stachelscheid, H.
01.01.20 → …
Projekt: DFG-Projekte › DFG-Verbundforschung: Sonderforschungsbereiche/ Transregios

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abstract = "In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH {\textquoteleft}central{\textquoteright} metabolic action, which was recently discovered in rodent models and challenged the previous {\textquoteleft}peripheral{\textquoteright} paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.",

author = "Valentina Capelli and Carlos Di{\'e}guez and Jens Mittag and Miguel L{\'o}pez",

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doi = "10.1016/j.tem.2021.05.006",

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Thyroid wars: the rise of central actions

Abstract

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Projekte

SFB/Transregio TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung

Zitieren