The VIZIER project: Preparedness against pathogenic RNA viruses

B. Coutard; A. E. Gorbalenya; E. J. Snijder; A. M. Leontovich; A. Poupon; X. De Lamballerie; R. Charrel; E. A. Gould; S. Gunther; H. Norder; B. Klempa; H. Bourhy; J. Rohayem; E. L'hermite; P. Nordlund; D. I. Stuart; R. J. Owens; J. M. Grimes; P. A. Tucker; M. Bolognesi; A. Mattevi; M. Coll; T. A. Jones; J. Åqvist; T. Unge; R. Hilgenfeld; G. Bricogne; J. Neyts; P. La Colla; G. Puerstinger; J. P. Gonzalez; E. Leroy; C. Cambillau; J. L. Romette; B. Canard

doi:10.1016/j.antiviral.2007.10.013

The VIZIER project: Preparedness against pathogenic RNA viruses

B. Coutard, A. E. Gorbalenya, E. J. Snijder, A. M. Leontovich, A. Poupon, X. De Lamballerie, R. Charrel, E. A. Gould, S. Gunther, H. Norder, B. Klempa, H. Bourhy, J. Rohayem, E. L'hermite, P. Nordlund, D. I. Stuart, R. J. Owens, J. M. Grimes, P. A. Tucker, M. BolognesiA. Mattevi, M. Coll, T. A. Jones, J. Åqvist, T. Unge, R. Hilgenfeld, G. Bricogne, J. Neyts, P. La Colla, G. Puerstinger, J. P. Gonzalez, E. Leroy, C. Cambillau, J. L. Romette, B. Canard^*

^*Korrespondierende/r Autor/-in für diese Arbeit

24 Zitate (Scopus)

Abstract

Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules.

Originalsprache	Englisch
Zeitschrift	Antiviral Research
Jahrgang	78
Ausgabenummer	1
Seiten (von - bis)	37-46
Seitenumfang	10
ISSN	0166-3542
DOIs	https://doi.org/10.1016/j.antiviral.2007.10.013
Publikationsstatus	Veröffentlicht - 01.04.2008

Fördermittel

We thank Ségolène Arnoux, Julie Caprili, and Tania Langon, from ALMA Consulting Group ( http://www.almacg.com ), for administrative management of the project, Fabrice Malergue for the VIZIER Industrial Platform (VIP), as well as many colleagues, labmates, and partners, too numerous to name, for their enthusiasm and commitment to the VIZIER project. This work was supported by the VIZIER integrated project (LSHG-CT-2004-511960) of the European Union 6th Framework Programme (FP6)

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Dokumente

10.1016/j.antiviral.2007.10.013

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Coutard, B., Gorbalenya, A. E., Snijder, E. J., Leontovich, A. M., Poupon, A., De Lamballerie, X., Charrel, R., Gould, E. A., Gunther, S., Norder, H., Klempa, B., Bourhy, H., Rohayem, J., L'hermite, E., Nordlund, P., Stuart, D. I., Owens, R. J., Grimes, J. M., Tucker, P. A., ... Canard, B. (2008). The VIZIER project: Preparedness against pathogenic RNA viruses. Antiviral Research, 78(1), 37-46. https://doi.org/10.1016/j.antiviral.2007.10.013

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abstract = "Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules.",

author = "B. Coutard and Gorbalenya, \{A. E.\} and Snijder, \{E. J.\} and Leontovich, \{A. M.\} and A. Poupon and \{De Lamballerie\}, X. and R. Charrel and Gould, \{E. A.\} and S. Gunther and H. Norder and B. Klempa and H. Bourhy and J. Rohayem and E. L'hermite and P. Nordlund and Stuart, \{D. I.\} and Owens, \{R. J.\} and Grimes, \{J. M.\} and Tucker, \{P. A.\} and M. Bolognesi and A. Mattevi and M. Coll and Jones, \{T. A.\} and J. {\AA}qvist and T. Unge and R. Hilgenfeld and G. Bricogne and J. Neyts and \{La Colla\}, P. and G. Puerstinger and Gonzalez, \{J. P.\} and E. Leroy and C. Cambillau and Romette, \{J. L.\} and B. Canard",

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Coutard, B, Gorbalenya, AE, Snijder, EJ, Leontovich, AM, Poupon, A, De Lamballerie, X, Charrel, R, Gould, EA, Gunther, S, Norder, H, Klempa, B, Bourhy, H, Rohayem, J, L'hermite, E, Nordlund, P, Stuart, DI, Owens, RJ, Grimes, JM, Tucker, PA, Bolognesi, M, Mattevi, A, Coll, M, Jones, TA, Åqvist, J, Unge, T, Hilgenfeld, R, Bricogne, G, Neyts, J, La Colla, P, Puerstinger, G, Gonzalez, JP, Leroy, E, Cambillau, C, Romette, JL & Canard, B 2008, 'The VIZIER project: Preparedness against pathogenic RNA viruses', Antiviral Research, Jg. 78, Nr. 1, S. 37-46. https://doi.org/10.1016/j.antiviral.2007.10.013

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T1 - The VIZIER project: Preparedness against pathogenic RNA viruses

AU - Coutard, B.

AU - Gorbalenya, A. E.

AU - Snijder, E. J.

AU - Leontovich, A. M.

AU - Poupon, A.

AU - De Lamballerie, X.

AU - Charrel, R.

AU - Gould, E. A.

AU - Gunther, S.

AU - Norder, H.

AU - Klempa, B.

AU - Bourhy, H.

AU - Rohayem, J.

AU - L'hermite, E.

AU - Nordlund, P.

AU - Stuart, D. I.

AU - Owens, R. J.

AU - Grimes, J. M.

AU - Tucker, P. A.

AU - Bolognesi, M.

AU - Mattevi, A.

AU - Coll, M.

AU - Jones, T. A.

AU - Åqvist, J.

AU - Unge, T.

AU - Hilgenfeld, R.

AU - Bricogne, G.

AU - Neyts, J.

AU - La Colla, P.

AU - Puerstinger, G.

AU - Gonzalez, J. P.

AU - Leroy, E.

AU - Cambillau, C.

AU - Romette, J. L.

AU - Canard, B.

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules.

AB - Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules.

UR - https://www.scopus.com/pages/publications/40849111934

U2 - 10.1016/j.antiviral.2007.10.013

DO - 10.1016/j.antiviral.2007.10.013

M3 - Journal articles

C2 - 18083241

AN - SCOPUS:40849111934

SN - 0166-3542

VL - 78

SP - 37

EP - 46

JO - Antiviral Research

JF - Antiviral Research

IS - 1

ER -

The VIZIER project: Preparedness against pathogenic RNA viruses

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

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