TY - JOUR
T1 - The value of methylprednisolone in the treatment of an experimental sensorineural hearing loss following drill-induced ossicular chain injury
T2 - A randomized, blinded study in guinea-pigs
AU - Schneider, Wolfgang
AU - Gjuric, Mislav
AU - Katalinic, Andreas
AU - Buhr, Wolfgang
AU - Wolf, Stephan Rüdiger
PY - 1998/3/18
Y1 - 1998/3/18
N2 - In a previously established animal model a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. In a placebo-controlled, randomized, blinded study methylprednisolone showed no protective effect in reducing or improving the auditory threshold shifts, which occurred within seconds after drilling and remained stable throughout the 5-week observation period. Therefore the otologic surgeon must pay close attention to avoiding any contact of a rotating burr with an ossicle in an intact ossicular chain.
AB - In a previously established animal model a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. In a placebo-controlled, randomized, blinded study methylprednisolone showed no protective effect in reducing or improving the auditory threshold shifts, which occurred within seconds after drilling and remained stable throughout the 5-week observation period. Therefore the otologic surgeon must pay close attention to avoiding any contact of a rotating burr with an ossicle in an intact ossicular chain.
UR - http://www.scopus.com/inward/record.url?scp=0031911595&partnerID=8YFLogxK
U2 - 10.1080/00016489850155125
DO - 10.1080/00016489850155125
M3 - Journal articles
C2 - 9504163
AN - SCOPUS:0031911595
SN - 0001-6489
VL - 118
SP - 52
EP - 55
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 1
ER -
