The Th1 life cycle: Molecular control of IFN-γ to IL-10 switching

Andrew Cope; Gaelle Le Friec; John Cardone; Claudia Kemper

doi:10.1016/j.it.2011.03.010

The Th1 life cycle: Molecular control of IFN-γ to IL-10 switching

Andrew Cope, Gaelle Le Friec, John Cardone, Claudia Kemper^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Systemische Entzündungsforschung

238 Zitate (Scopus)

Abstract

Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces " intrinsic" IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field.

Originalsprache	Englisch
Zeitschrift	Trends in Immunology
Jahrgang	32
Ausgabenummer	6
Seiten (von - bis)	278-286
Seitenumfang	9
ISSN	1471-4906
DOIs	https://doi.org/10.1016/j.it.2011.03.010
Publikationsstatus	Veröffentlicht - 06.2011

Fördermittel

Research in the Cope and Kemper laboratories is supported by Arthritis Research UK, The Wellcome Trust, the Medical Research Council (MRC) and The Nuffield Foundation, the EU-funded Innovative Medicines Initiative BTCURE, the MRC Centre for Transplantation, Guy's Hospital, King's College, and the Department of Health, National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas’ NHS Foundation Trust, in partnership with King's College London and King's College Hospital NHS Foundation Trust.

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Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1016/j.it.2011.03.010

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title = "The Th1 life cycle: Molecular control of IFN-γ to IL-10 switching",

abstract = "Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces {"} intrinsic{"} IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field.",

author = "Andrew Cope and \{Le Friec\}, Gaelle and John Cardone and Claudia Kemper",

note = "Funding Information: Research in the Cope and Kemper laboratories is supported by Arthritis Research UK, The Wellcome Trust, the Medical Research Council (MRC) and The Nuffield Foundation, the EU-funded Innovative Medicines Initiative BTCURE, the MRC Centre for Transplantation, Guy's Hospital, King's College, and the Department of Health, National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's \& St Thomas{\textquoteright} NHS Foundation Trust, in partnership with King's College London and King's College Hospital NHS Foundation Trust.",

year = "2011",

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doi = "10.1016/j.it.2011.03.010",

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journal = "Trends in Immunology",

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T1 - The Th1 life cycle: Molecular control of IFN-γ to IL-10 switching

AU - Cope, Andrew

AU - Le Friec, Gaelle

AU - Cardone, John

AU - Kemper, Claudia

N1 - Funding Information: Research in the Cope and Kemper laboratories is supported by Arthritis Research UK, The Wellcome Trust, the Medical Research Council (MRC) and The Nuffield Foundation, the EU-funded Innovative Medicines Initiative BTCURE, the MRC Centre for Transplantation, Guy's Hospital, King's College, and the Department of Health, National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas’ NHS Foundation Trust, in partnership with King's College London and King's College Hospital NHS Foundation Trust.

PY - 2011/6

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N2 - Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces " intrinsic" IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field.

AB - Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces " intrinsic" IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field.

UR - https://www.scopus.com/pages/publications/79957713226

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DO - 10.1016/j.it.2011.03.010

M3 - Scientific review articles

C2 - 21531623

AN - SCOPUS:79957713226

SN - 1471-4906

VL - 32

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EP - 286

JO - Trends in Immunology

JF - Trends in Immunology

IS - 6

ER -

The Th1 life cycle: Molecular control of IFN-γ to IL-10 switching

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

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