The Telomeric Complex and Metabolic Disease

Henriette Kirchner; Fozia Shaheen; Hannes Kalscheuer; Sebastian M. Schmid; Henrik Oster; Hendrik Lehnert

doi:10.3390/genes8070176

The Telomeric Complex and Metabolic Disease

Henriette Kirchner, Fozia Shaheen, Hannes Kalscheuer, Sebastian M. Schmid, Henrik Oster, Hendrik Lehnert^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Stratlab Ltd.

44 Zitate (Scopus)

Abstract

The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.

Originalsprache	Englisch
Aufsatznummer	176
Zeitschrift	Genes
Jahrgang	8
Ausgabenummer	7
DOIs	https://doi.org/10.3390/genes8070176
Publikationsstatus	Veröffentlicht - 07.07.2017

Fördermittel

This work was supported bv the Deutsche Forschungsgemeinschaft (Emmy-Noether Program KI1887/2-1; SFB-134; GRK-1957).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 8 – Angemessene Arbeitsbedingungen und wirtschaftliches Wachstum
SDG 10 – Weniger Ungleichheiten

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Dokumente

10.3390/genes8070176

Weitere Links

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AU - Lehnert, Hendrik

PY - 2017/7/7

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The Telomeric Complex and Metabolic Disease

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

Weitere Links

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