The state of complement in COVID-19

Behdad Afzali; Marina Noris; Bart N. Lambrecht; Claudia Kemper

doi:10.1038/s41577-021-00665-1

The state of complement in COVID-19

Behdad Afzali^*, Marina Noris^*, Bart N. Lambrecht^*, Claudia Kemper^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Systemische Entzündungsforschung

120 Zitate (Scopus)

Abstract

Hyperactivation of the complement and coagulation systems is recognized as part of the clinical syndrome of COVID-19. Here we review systemic complement activation and local complement activation in response to the causative virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their currently known relationships to hyperinflammation and thrombosis. We also provide an update on early clinical findings and emerging clinical trial evidence that suggest potential therapeutic benefit of complement inhibition in severe COVID-19.

Originalsprache	Englisch
Zeitschrift	Nature Reviews Immunology
Jahrgang	22
Ausgabenummer	2
Seiten (von - bis)	77-84
Seitenumfang	8
ISSN	1474-1733
DOIs	https://doi.org/10.1038/s41577-021-00665-1
Publikationsstatus	Veröffentlicht - 02.2022

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

DFG-Fachsystematik

2.21-05 Immunologie

Coronavirus-Bezug

Forschung zu SARS-CoV-2 / COVID-19

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

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10.1038/s41577-021-00665-1

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The state of complement in COVID-19

Abstract

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Coronavirus-Bezug

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

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Zitieren