Abstract
Thyroid hormone (TH) regulation is important for development, energy homeostasis, heart function, and bone formation. To control the effects of TH in target organs, the hypothalamus-pituitary-thyroid (HPT) axis and the tissue-specific availability of TH are highly regulated by negative feedback. To exert a central feedback, TH must enter the brain via specific transport mechanisms and cross the blood-brain barrier. Here, tanycytes, which are located in the ventral walls of the 3 rd ventricle in the mediobasal hypothalamus (MBH), function as gatekeepers. Tanycytes are able to transport, sense, and modify the release of hormones of the HPT axis and are involved in feedback regulation. In this review, we focus on the relevance of tanycytes in thyrotropin-releasing hormone (TRH) release and review available genetic tools to investigate the physiological functions of these cells.
| Originalsprache | Englisch |
|---|---|
| Zeitschrift | Experimental and Clinical Endocrinology and Diabetes |
| Jahrgang | 128 |
| Ausgabenummer | 6-7 |
| Seiten (von - bis) | 388-394 |
| Seitenumfang | 7 |
| ISSN | 0947-7349 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 01.06.2020 |
Fördermittel
Authors were funded by the Deutsche Forschungsgemeinschaft (SPP1629, MU 3743/1–1 to H.M.F.) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 810331).
UN SDGs
Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung
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SDG 3 – Gesundheit und Wohlergehen
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
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