The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

Leonardo Vinícius Monteiro De Assis; Jamille Locatelli; Mauro César Isoldi

doi:10.1016/j.bbcan.2014.01.008

The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

Leonardo Vinícius Monteiro De Assis, Jamille Locatelli, Mauro César Isoldi^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Neurobiologie

Federal University of Ouro Preto

53 Zitate (Scopus)

Abstract

Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16^INK4a, p14^ARF, NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.

Originalsprache	Englisch
Zeitschrift	Biochimica et Biophysica Acta - Reviews on Cancer
Jahrgang	1845
Ausgabenummer	2
Seiten (von - bis)	232-247
Seitenumfang	16
ISSN	0304-419X
DOIs	https://doi.org/10.1016/j.bbcan.2014.01.008
Publikationsstatus	Veröffentlicht - 04.2014

Fördermittel

The first author of this paper thanks CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and the Brazilian government through the Science without Borders program for granting a one year full scholarship at the University of Montana, USA; Dr. Mark Pershouse, associate professor of the Department of Biomedical and Pharmaceutical Science at the University of Montana, USA, for his teachings, lessons and mentoring. All the authors of this paper thank Pablo Henrique Oliveira e Silva for extensively revising this manuscript; Izabella Imperatriz Moreira Dalboni de Souza for editing the figures present in this paper; CNPQ and Fundação de Amparo à Pesquisa do estado de Minas Gerais (FAPEMIG , grants APQ 2112-10 and APQ 00793-13 ) for the financial support given to our Laboratory at the Federal University of Ouro Preto (UFOP).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 8 – Angemessene Arbeitsbedingungen und wirtschaftliches Wachstum
SDG 10 – Weniger Ungleichheiten

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10.1016/j.bbcan.2014.01.008

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title = "The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma",

abstract = "Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16INK4a, p14ARF, NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.",

author = "\{De Assis\}, \{Leonardo Vin{\'i}cius Monteiro\} and Jamille Locatelli and Isoldi, \{Mauro C{\'e}sar\}",

note = "Funding Information: The first author of this paper thanks CAPES (Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior) and the Brazilian government through the Science without Borders program for granting a one year full scholarship at the University of Montana, USA; Dr. Mark Pershouse, associate professor of the Department of Biomedical and Pharmaceutical Science at the University of Montana, USA, for his teachings, lessons and mentoring. All the authors of this paper thank Pablo Henrique Oliveira e Silva for extensively revising this manuscript; Izabella Imperatriz Moreira Dalboni de Souza for editing the figures present in this paper; CNPQ and Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do estado de Minas Gerais (FAPEMIG , grants APQ 2112-10 and APQ 00793-13 ) for the financial support given to our Laboratory at the Federal University of Ouro Preto (UFOP).",

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doi = "10.1016/j.bbcan.2014.01.008",

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AB - Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16INK4a, p14ARF, NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.

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The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

Abstract

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