The role and clinical relevance of disseminated tumor cells in breast cancer

Malgorzata Banys*, Natalia Krawczyk, Tanja Fehm

*Korrespondierende/r Autor/-in für diese Arbeit
16 Zitate (Scopus)

Abstract

Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.

OriginalspracheEnglisch
ZeitschriftCancers
Jahrgang6
Ausgabenummer1
Seiten (von - bis)143-152
Seitenumfang10
ISSN2072-6694
DOIs
PublikationsstatusVeröffentlicht - 03.2014

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