The relevance of complement in pemphigoid diseases: A critical appraisal

Cristian Papara; Christian M. Karsten; Hideyuki Ujiie; Enno Schmidt; Leon F. Schmidt-Jiménez; Adrian Baican; Patricia C. Freire; Kentaro Izumi; Katja Bieber; Matthias Peipp; Admar Verschoor; Ralf J. Ludwig; Jörg Köhl; Detlef Zillikens; Christoph M. Hammers

doi:10.3389/fimmu.2022.973702

The relevance of complement in pemphigoid diseases: A critical appraisal

Cristian Papara, Christian M. Karsten, Hideyuki Ujiie, Enno Schmidt, Leon F. Schmidt-Jiménez, Adrian Baican, Patricia C. Freire, Kentaro Izumi, Katja Bieber, Matthias Peipp, Admar Verschoor, Ralf J. Ludwig, Jörg Köhl, Detlef Zillikens, Christoph M. Hammers^*

^*Korrespondierende/r Autor/-in für diese Arbeit

22 Zitate (Scopus)

Abstract

Pemphigoid diseases are autoimmune chronic inflammatory skin diseases, which are characterized by blistering of the skin and/or mucous membranes, and circulating and tissue-bound autoantibodies. The well-established pathomechanisms comprise autoantibodies targeting various structural proteins located at the dermal-epidermal junction, leading to complement factor binding and activation. Several effector cells are thus attracted and activated, which in turn inflict characteristic tissue damage and subepidermal blistering. Moreover, the detection of linear complement deposits in the skin is a diagnostic hallmark of all pemphigoid diseases. However, recent studies showed that blistering might also occur independently of complement. This review reassesses the importance of complement in pemphigoid diseases based on current research by contrasting and contextualizing data from in vitro, murine and human studies.

Originalsprache	Englisch
Aufsatznummer	973702
Zeitschrift	Frontiers in Immunology
Jahrgang	13
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2022.973702
Publikationsstatus	Veröffentlicht - 16.08.2022

Fördermittel

This research was supported by DFG funding for the Collaborative Research Center (CRC) 1526 – Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU) – Insights from Pemphigoid Diseases (Grant No.: 454193335), the CRU 303 P7, the Research Training Group “Autoimmune Pre-Disease” (GRK 2633), the Schleswig-Holstein Excellence-Chair Program from the State of Schleswig Holstein, the Excellence Cluster EXC 2167 Precision Medicine in Chronic Inflammation (TI-4), and the Sinergia Unravel principles of self-organization in injured tissue (CRSII5_202301/1) from the Swiss National Science Foundation.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)
Zentren: Center for Research on Inflammation of the Skin (CRIS)

DFG-Fachsystematik

2.21-05 Immunologie
2.22-19 Dermatologie

Dokumente

10.3389/fimmu.2022.973702

Weitere Links

Link to publication in Scopus

SFB 1526, PANTAU: Pathomechanismen Antikörpervermittelter Autoimmunerkrankungen
Sadik, C. (Sprecher*in), Zillikens, D. (Sprecher*in), Scheffold, A. (Projektleiter*in (PI)), Schmidt, E. (Projektleiter*in (PI)), Heine, G. (Projektleiter*in (PI)), Manz, R. (Projektleiter*in (PI)), Köhl, J. (Projektleiter*in (PI)), Ludwig, R. (Projektleiter*in (PI)), Peipp, M. (Projektleiter*in (PI)), Hammers, M. C. (Projektleiter*in (PI)), Verschoor, A. (Projektleiter*in (PI)), Karsten, C. (Projektleiter*in (PI)), Nimmerjahn, F. (Projektleiter*in (PI)), Hutloff, A. (Projektleiter*in (PI)), Ibrahim, S. (Projektleiter*in (PI)), Wettschureck, N. (Projektleiter*in (PI)), Bieber, K. (Projektleiter*in (PI)), Schilf, P. (Projektleiter*in (PI)), Vaeth, M. (Projektleiter*in (PI)), Hirose, M. (Projektleiter*in (PI)), Vaeth, M. (Projektleiter*in (PI)), Baines, J. F. (Projektleiter*in (PI)), Bacher, P. (Projektleiter*in (PI)), Hoffmann, M. (Projektleiter*in (PI)), Busch, H. S. (Projektleiter*in (PI)), Höppner, M. (Projektleiter*in (PI)), Becker, M. (Projektleiter*in (PI)), Holtsche, M. M. (Projektleiter*in (PI)), Fähnrich, A. (Projektleiter*in (PI)), Szymczak, S. (Projektleiter*in (PI)), Murthy, S. (Projektleiter*in (PI)) & Lux, A. (Projektleiter*in (PI))
01.01.22 → …
Projekt: DFG Verbundprojekte › DFG Sonderforschungsbereiche / Transregios (SFB/TR)

Zitieren

Papara, C., Karsten, C. M., Ujiie, H., Schmidt, E., Schmidt-Jiménez, L. F., Baican, A., Freire, P. C., Izumi, K., Bieber, K., Peipp, M., Verschoor, A., Ludwig, R. J., Köhl, J., Zillikens, D., & Hammers, C. M. (2022). The relevance of complement in pemphigoid diseases: A critical appraisal. Frontiers in Immunology, 13, Artikel 973702. https://doi.org/10.3389/fimmu.2022.973702

@article{f833bc1499594586984c899ecfda400c,

title = "The relevance of complement in pemphigoid diseases: A critical appraisal",

abstract = "Pemphigoid diseases are autoimmune chronic inflammatory skin diseases, which are characterized by blistering of the skin and/or mucous membranes, and circulating and tissue-bound autoantibodies. The well-established pathomechanisms comprise autoantibodies targeting various structural proteins located at the dermal-epidermal junction, leading to complement factor binding and activation. Several effector cells are thus attracted and activated, which in turn inflict characteristic tissue damage and subepidermal blistering. Moreover, the detection of linear complement deposits in the skin is a diagnostic hallmark of all pemphigoid diseases. However, recent studies showed that blistering might also occur independently of complement. This review reassesses the importance of complement in pemphigoid diseases based on current research by contrasting and contextualizing data from in vitro, murine and human studies.",

author = "Cristian Papara and Karsten, \{Christian M.\} and Hideyuki Ujiie and Enno Schmidt and Schmidt-Jim{\'e}nez, \{Leon F.\} and Adrian Baican and Freire, \{Patricia C.\} and Kentaro Izumi and Katja Bieber and Matthias Peipp and Admar Verschoor and Ludwig, \{Ralf J.\} and J{\"o}rg K{\"o}hl and Detlef Zillikens and Hammers, \{Christoph M.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Papara, Karsten, Ujiie, Schmidt, Schmidt-Jim{\'e}nez, Baican, Freire, Izumi, Bieber, Peipp, Verschoor, Ludwig, K{\"o}hl, Zillikens and Hammers.",

year = "2022",

month = aug,

day = "16",

doi = "10.3389/fimmu.2022.973702",

language = "English",

volume = "13",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media",

}

TY - JOUR

T1 - The relevance of complement in pemphigoid diseases

T2 - A critical appraisal

AU - Papara, Cristian

AU - Karsten, Christian M.

AU - Ujiie, Hideyuki

AU - Schmidt, Enno

AU - Schmidt-Jiménez, Leon F.

AU - Baican, Adrian

AU - Freire, Patricia C.

AU - Izumi, Kentaro

AU - Bieber, Katja

AU - Peipp, Matthias

AU - Verschoor, Admar

AU - Ludwig, Ralf J.

AU - Köhl, Jörg

AU - Zillikens, Detlef

AU - Hammers, Christoph M.

PY - 2022/8/16

Y1 - 2022/8/16

N2 - Pemphigoid diseases are autoimmune chronic inflammatory skin diseases, which are characterized by blistering of the skin and/or mucous membranes, and circulating and tissue-bound autoantibodies. The well-established pathomechanisms comprise autoantibodies targeting various structural proteins located at the dermal-epidermal junction, leading to complement factor binding and activation. Several effector cells are thus attracted and activated, which in turn inflict characteristic tissue damage and subepidermal blistering. Moreover, the detection of linear complement deposits in the skin is a diagnostic hallmark of all pemphigoid diseases. However, recent studies showed that blistering might also occur independently of complement. This review reassesses the importance of complement in pemphigoid diseases based on current research by contrasting and contextualizing data from in vitro, murine and human studies.

AB - Pemphigoid diseases are autoimmune chronic inflammatory skin diseases, which are characterized by blistering of the skin and/or mucous membranes, and circulating and tissue-bound autoantibodies. The well-established pathomechanisms comprise autoantibodies targeting various structural proteins located at the dermal-epidermal junction, leading to complement factor binding and activation. Several effector cells are thus attracted and activated, which in turn inflict characteristic tissue damage and subepidermal blistering. Moreover, the detection of linear complement deposits in the skin is a diagnostic hallmark of all pemphigoid diseases. However, recent studies showed that blistering might also occur independently of complement. This review reassesses the importance of complement in pemphigoid diseases based on current research by contrasting and contextualizing data from in vitro, murine and human studies.

UR - https://www.scopus.com/pages/publications/85137214091

U2 - 10.3389/fimmu.2022.973702

DO - 10.3389/fimmu.2022.973702

M3 - Scientific review articles

C2 - 36059476

AN - SCOPUS:85137214091

SN - 1664-3224

VL - 13

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 973702

ER -

The relevance of complement in pemphigoid diseases: A critical appraisal

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

Weitere Links

Fingerprint

Projekte

SFB 1526, PANTAU: Pathomechanismen Antikörpervermittelter Autoimmunerkrankungen

Zitieren