The pioneer round of translation: Features and functions

Lynne E. Maquat; Woan Yuh Tarn; Olaf Isken

doi:10.1016/j.cell.2010.07.022

The pioneer round of translation: Features and functions

Lynne E. Maquat^*, Woan Yuh Tarn, Olaf Isken

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Virologie und Zellbiologie

99 Zitate (Scopus)

Abstract

In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

Originalsprache	Englisch
Zeitschrift	Cell
Jahrgang	142
Ausgabenummer	3
Seiten (von - bis)	368-374
Seitenumfang	7
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2010.07.022
Publikationsstatus	Veröffentlicht - 01.08.2010

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10.1016/j.cell.2010.07.022

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abstract = "In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.",

author = "Maquat, {Lynne E.} and Tarn, {Woan Yuh} and Olaf Isken",

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AU - Tarn, Woan Yuh

AU - Isken, Olaf

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AB - In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

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U2 - 10.1016/j.cell.2010.07.022

DO - 10.1016/j.cell.2010.07.022

M3 - Scientific review articles

C2 - 20691898

AN - SCOPUS:77955326776

SN - 0092-8674

VL - 142

SP - 368

EP - 374

JO - Cell

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The pioneer round of translation: Features and functions

Abstract

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