The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR)

Khaled Nassar; Julia Lüke; Matthias Lüke; Mahmoud Kamal; Effat Abd El-Nabi; Mahmoud Soliman; Martin Rohrbach; Salvatore Grisanti

doi:10.1007/s00417-011-1730-9

The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR)

Khaled Nassar^*, Julia Lüke, Matthias Lüke, Mahmoud Kamal, Effat Abd El-Nabi, Mahmoud Soliman, Martin Rohrbach, Salvatore Grisanti

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Augenheilkunde

46 Zitate (Scopus)

Abstract

Background: The cytokine transforming growth factor- (TGF-β) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. This study evaluates the effect of decorin, a naturally occurring TGF-β inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). Methods: Traumatic PVR was induced in 50 rabbits divided into ten groups (n=5). One group (GI) reveals a control with no treatment after trauma. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points; (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. GIII and GIV received 100 μg or 200 μg decorin, respectively. PVR severity was scored from 0 to 4. The amount of fibrosis was quantified using JMicroVision

Originalsprache	Englisch
Zeitschrift	Graefe's Archive for Clinical and Experimental Ophthalmology
Jahrgang	249
Ausgabenummer	11
Seiten (von - bis)	1649-1660
Seitenumfang	12
ISSN	0721-832X
DOIs	https://doi.org/10.1007/s00417-011-1730-9
Publikationsstatus	Veröffentlicht - 11.2011

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Acknowledgements This study was supported in part by Herbert Funke Foundation, Germany and by the ministry of high education of the Egyptian government. We thank Mrs. Christine Örün for her technical assistance.

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SDG 3 – Gesundheit und Wohlergehen

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Profilbereich: Lübeck Integrated Oncology Network (LION)

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10.1007/s00417-011-1730-9

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@article{25c184843fc942b0b7bb4a8f1d149f74,

title = "The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR)",

abstract = "Background: The cytokine transforming growth factor- (TGF-β) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. This study evaluates the effect of decorin, a naturally occurring TGF-β inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). Methods: Traumatic PVR was induced in 50 rabbits divided into ten groups (n=5). One group (GI) reveals a control with no treatment after trauma. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points; (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. GIII and GIV received 100 μg or 200 μg decorin, respectively. PVR severity was scored from 0 to 4. The amount of fibrosis was quantified using JMicroVision",

author = "Khaled Nassar and Julia L{\"u}ke and Matthias L{\"u}ke and Mahmoud Kamal and \{Abd El-Nabi\}, Effat and Mahmoud Soliman and Martin Rohrbach and Salvatore Grisanti",

note = "Funding Information: Acknowledgements This study was supported in part by Herbert Funke Foundation, Germany and by the ministry of high education of the Egyptian government. We thank Mrs. Christine {\"O}r{\"u}n for her technical assistance. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2011",

month = nov,

doi = "10.1007/s00417-011-1730-9",

language = "English",

volume = "249",

pages = "1649--1660",

journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",

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T1 - The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR)

AU - Nassar, Khaled

AU - Lüke, Julia

AU - Lüke, Matthias

AU - Kamal, Mahmoud

AU - Abd El-Nabi, Effat

AU - Soliman, Mahmoud

AU - Rohrbach, Martin

AU - Grisanti, Salvatore

N1 - Funding Information: Acknowledgements This study was supported in part by Herbert Funke Foundation, Germany and by the ministry of high education of the Egyptian government. We thank Mrs. Christine Örün for her technical assistance. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2011/11

Y1 - 2011/11

N2 - Background: The cytokine transforming growth factor- (TGF-β) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. This study evaluates the effect of decorin, a naturally occurring TGF-β inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). Methods: Traumatic PVR was induced in 50 rabbits divided into ten groups (n=5). One group (GI) reveals a control with no treatment after trauma. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points; (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. GIII and GIV received 100 μg or 200 μg decorin, respectively. PVR severity was scored from 0 to 4. The amount of fibrosis was quantified using JMicroVision

AB - Background: The cytokine transforming growth factor- (TGF-β) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. This study evaluates the effect of decorin, a naturally occurring TGF-β inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). Methods: Traumatic PVR was induced in 50 rabbits divided into ten groups (n=5). One group (GI) reveals a control with no treatment after trauma. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points; (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. GIII and GIV received 100 μg or 200 μg decorin, respectively. PVR severity was scored from 0 to 4. The amount of fibrosis was quantified using JMicroVision

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DO - 10.1007/s00417-011-1730-9

M3 - Journal articles

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AN - SCOPUS:80755128427

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JF - Graefe's Archive for Clinical and Experimental Ophthalmology

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ER -

The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR)

Abstract

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UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

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