TY - JOUR
T1 - The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR)
AU - Nassar, Khaled
AU - Lüke, Julia
AU - Lüke, Matthias
AU - Kamal, Mahmoud
AU - Abd El-Nabi, Effat
AU - Soliman, Mahmoud
AU - Rohrbach, Martin
AU - Grisanti, Salvatore
N1 - Funding Information:
Acknowledgements This study was supported in part by Herbert Funke Foundation, Germany and by the ministry of high education of the Egyptian government. We thank Mrs. Christine Örün for her technical assistance.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/11
Y1 - 2011/11
N2 - Background: The cytokine transforming growth factor- (TGF-β) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. This study evaluates the effect of decorin, a naturally occurring TGF-β inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). Methods: Traumatic PVR was induced in 50 rabbits divided into ten groups (n=5). One group (GI) reveals a control with no treatment after trauma. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points; (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. GIII and GIV received 100 μg or 200 μg decorin, respectively. PVR severity was scored from 0 to 4. The amount of fibrosis was quantified using JMicroVision
AB - Background: The cytokine transforming growth factor- (TGF-β) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion. This study evaluates the effect of decorin, a naturally occurring TGF-β inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). Methods: Traumatic PVR was induced in 50 rabbits divided into ten groups (n=5). One group (GI) reveals a control with no treatment after trauma. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points; (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. GIII and GIV received 100 μg or 200 μg decorin, respectively. PVR severity was scored from 0 to 4. The amount of fibrosis was quantified using JMicroVision
UR - http://www.scopus.com/inward/record.url?scp=80755128427&partnerID=8YFLogxK
U2 - 10.1007/s00417-011-1730-9
DO - 10.1007/s00417-011-1730-9
M3 - Journal articles
C2 - 21735240
AN - SCOPUS:80755128427
SN - 0721-832X
VL - 249
SP - 1649
EP - 1660
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 11
ER -