Abstract
In the presence of the murine cytomegalovirus (mCMV) gp40 (m152) protein, murine major histocompatibility complex (MHC) class I molecules do not reach the cell surface but are retained in an early compartment of the secretory pathway. We find that gp40 does not impair the folding or high-affinity peptide binding of the class I molecules but binds to them, leading to their retention in the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC) and the cis-Golgi, most likely by retrieval from the cis-Golgi to the ER.We identify a sequence in gp40 that is required for both its own retention in the early secretory pathway and for that of class I molecules.
Originalsprache | Englisch |
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Zeitschrift | Journal of Cell Science |
Jahrgang | 129 |
Ausgabenummer | 1 |
Seiten (von - bis) | 219-227 |
Seitenumfang | 9 |
ISSN | 0021-9533 |
DOIs | |
Publikationsstatus | Veröffentlicht - 01.01.2016 |
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)