The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat

Mariana Astiz; María J.T. de Alaniz; Carlos Alberto Marra

doi:10.1016/j.pestbp.2009.03.005

The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat

Mariana Astiz, María J.T. de Alaniz, Carlos Alberto Marra^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Neurobiologie

Universität in La Plata

28 Zitate (Scopus)

Abstract

It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress status in the plasma, liver, and testes, and also modified hormonal parameters involved in reproductive function. The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats. These effects were more pronounced when pesticides were administered in combination, and should be considered indicative of involuntary exposure to residual agrochemicals.

Originalsprache	Englisch
Zeitschrift	Pesticide Biochemistry and Physiology
Jahrgang	94
Ausgabenummer	2-3
Seiten (von - bis)	93-99
Seitenumfang	7
ISSN	0048-3575
DOIs	https://doi.org/10.1016/j.pestbp.2009.03.005
Publikationsstatus	Veröffentlicht - 06.2009

Fördermittel

This study was supported by a Grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). We would like to thank Miss Norma Cristalli for technical assistance.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 8 – Angemessene Arbeitsbedingungen und wirtschaftliches Wachstum
SDG 10 – Weniger Ungleichheiten

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Dokumente

10.1016/j.pestbp.2009.03.005

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title = "The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat",

abstract = "It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress status in the plasma, liver, and testes, and also modified hormonal parameters involved in reproductive function. The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats. These effects were more pronounced when pesticides were administered in combination, and should be considered indicative of involuntary exposure to residual agrochemicals.",

author = "Mariana Astiz and \{de Alaniz\}, \{Mar{\'i}a J.T.\} and Marra, \{Carlos Alberto\}",

note = "Funding Information: This study was supported by a Grant from Consejo Nacional de Investigaciones Cient{\'i}ficas y T{\'e}cnicas (CONICET). We would like to thank Miss Norma Cristalli for technical assistance. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2009",

month = jun,

doi = "10.1016/j.pestbp.2009.03.005",

language = "English",

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AU - Astiz, Mariana

AU - de Alaniz, María J.T.

AU - Marra, Carlos Alberto

N1 - Funding Information: This study was supported by a Grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). We would like to thank Miss Norma Cristalli for technical assistance. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2009/6

Y1 - 2009/6

N2 - It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress status in the plasma, liver, and testes, and also modified hormonal parameters involved in reproductive function. The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats. These effects were more pronounced when pesticides were administered in combination, and should be considered indicative of involuntary exposure to residual agrochemicals.

AB - It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress status in the plasma, liver, and testes, and also modified hormonal parameters involved in reproductive function. The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats. These effects were more pronounced when pesticides were administered in combination, and should be considered indicative of involuntary exposure to residual agrochemicals.

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DO - 10.1016/j.pestbp.2009.03.005

M3 - Journal articles

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SN - 0048-3575

VL - 94

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EP - 99

JO - Pesticide Biochemistry and Physiology

JF - Pesticide Biochemistry and Physiology

IS - 2-3

ER -

The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

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