The immune contexture of hepatocellular carcinoma predicts clinical outcome

Friedrich Foerster, Moritz Hess, Aslihan Gerhold-Ay, Jens Uwe Marquardt, Diana Becker, Peter Robert Galle, Detlef Schuppan, Harald Binder, Ernesto Bockamp*

*Korrespondierende/r Autor/-in für diese Arbeit
35 Zitate (Scopus)

Abstract

The general relevance of the immune system for cancer development and therapy is increasingly recognized. However and although the immune contexture of most human cancer types has been determined, a global characterisation of the immune tumour microenvironment in hepatocellular carcinoma (HCC) is lacking. Equally, differences in the immune contexture of HCC between different patient subgroups and its effect on survival remain to be established. Here we report an in silico analysis of the immune contexture of human HCC. Using large deep sequencing HCC tumour, adjacent non-tumour and healthy liver high-dimensional data sets, we were able to reveal previously unrecognized differences in the immune contexture of HCC. Strikingly, we found that different etiologies and HCC stages were not associated with major changes in the immune contexture. In contrast, the presence of T cells and cytotoxic cells as well as the absence of macrophages and Th2 cells positively correlated with patient survival. Based on these novel findings, we developed a prognostic score that accurately distinguishes between patients with good and poor survival. Our study provides the first global characterisation of the immune contexture of HCC and will have direct implications for future HCC therapies.

OriginalspracheEnglisch
Aufsatznummer5351
ZeitschriftScientific Reports
Jahrgang8
Ausgabenummer1
ISSN2045-2322
DOIs
PublikationsstatusVeröffentlicht - 01.12.2018

Fingerprint

Untersuchen Sie die Forschungsthemen von „The immune contexture of hepatocellular carcinoma predicts clinical outcome“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren