The G protein-coupled receptor 15 (GPR15) regulates cutaneous immunology by maintaining dendritic epidermal T cells and regulating the skin microbiome

Tanya Sezin, Lina Jegodzinski, Lisa Maria Meyne, Yask Gupta, Sadegh Mousavi, Ralf J. Ludwig, Detlef Zillikens, Christian D. Sadik*

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

The G protein-coupled receptor 15 (GPR15) regulates homing of different T-cell populations into the gut, thus, preserving tissue homeostasis. Its potential role in the preservation of homeostasis on other body interfaces, including the skin, is less well understood. We addressed the impact of GPR15 on cutaneous T-cell populations and the skin microbiome under steady-state conditions. Genetic deficiency in GPR15 substantially altered the composition of skin-resident T-cell populations. Precisely, dendritic epidermal T cells were almost absent in the epidermis of Gpr15–/– mice. The niche of dendritic epidermal T cells in the epidermis was, instead, populated by αβ TCR+ T cells. These changes were associated with shifts in the skin microbiota in Gpr15–/– mice. Collectively, our results uncover a role of GPR15 in the regulation of the cutaneous immune system and, thus, highlight the receptor as important general regulator of tissue homeostasis of exterior body interfaces.

OriginalspracheEnglisch
ZeitschriftEuropean Journal of Immunology
Jahrgang51
Ausgabenummer6
Seiten (von - bis)1390-1398
Seitenumfang9
ISSN0014-2980
DOIs
PublikationsstatusVeröffentlicht - 06.2021

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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