The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

Vedrana Tadic*, Tino Prell, Janin Lautenschlaeger, Julian Grosskreutz

*Korrespondierende/r Autor/-in für diese Arbeit
87 Zitate (Scopus)

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. although the etiology remains unclear, Disturbances in calcium homoeostasis and protein folding are essential features of neurodegeneration in this disorder. here, We review recent research findings on the interaction between endoplasmic reticulum (ER) and mitochondria, And its effect on calcium signaling and oxidative stress. we further provide insights into studies, Providing evidence that structures of the ER mitochondria calcium cycle serve as a promising targets for therapeutic approaches for treatment of ALS.

OriginalspracheEnglisch
Aufsatznummer147
ZeitschriftFrontiers in Cellular Neuroscience
Jahrgang8
AusgabenummerMAY
ISSN1662-5102
DOIs
PublikationsstatusVeröffentlicht - 30.05.2014
Extern publiziertJa

Strategische Forschungsbereiche und Zentren

  • Zentren: Neuromuskuläres Zentrum Schleswig-Holstein

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