The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Adam P. Chambers; Henriette Kirchner; Hilary E. Wilson-Perez; Jill A. Willency; John E. Hale; Bruce D. Gaylinn; Michael O. Thorner; Paul T. Pfluger; Jesus A. Gutierrez; Matthias H. Tschöp; Darleen A. Sandoval; Randy J. Seeley

doi:10.1053/j.gastro.2012.09.009

The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Adam P. Chambers^*, Henriette Kirchner, Hilary E. Wilson-Perez, Jill A. Willency, John E. Hale, Bruce D. Gaylinn, Michael O. Thorner, Paul T. Pfluger, Jesus A. Gutierrez, Matthias H. Tschöp, Darleen A. Sandoval, Randy J. Seeley

^*Korrespondierende/r Autor/-in für diese Arbeit

Medizinische Klinik I

78 Zitate (Scopus)

Abstract

Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

Originalsprache	Englisch
Zeitschrift	Gastroenterology
Jahrgang	144
Ausgabenummer	1
Seiten (von - bis)	50-52.e5
ISSN	0016-5085
DOIs	https://doi.org/10.1053/j.gastro.2012.09.009
Publikationsstatus	Veröffentlicht - 01.01.2013

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title = "The effects of vertical sleeve gastrectomy in rodents are ghrelin independent",

abstract = "Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.",

author = "Chambers, {Adam P.} and Henriette Kirchner and Wilson-Perez, {Hilary E.} and Willency, {Jill A.} and Hale, {John E.} and Gaylinn, {Bruce D.} and Thorner, {Michael O.} and Pfluger, {Paul T.} and Gutierrez, {Jesus A.} and Tsch{\"o}p, {Matthias H.} and Sandoval, {Darleen A.} and Seeley, {Randy J.}",

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AU - Chambers, Adam P.

AU - Kirchner, Henriette

AU - Wilson-Perez, Hilary E.

AU - Willency, Jill A.

AU - Hale, John E.

AU - Gaylinn, Bruce D.

AU - Thorner, Michael O.

AU - Pfluger, Paul T.

AU - Gutierrez, Jesus A.

AU - Tschöp, Matthias H.

AU - Sandoval, Darleen A.

AU - Seeley, Randy J.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

AB - Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

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DO - 10.1053/j.gastro.2012.09.009

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SN - 0016-5085

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SP - 50-52.e5

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JF - Gastroenterology

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ER -

The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Abstract

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