The cysteine-rich region of type VII collagen is a cystine knot with a new topology

Henrik Wegener; Hauke Paulsen; Karsten Seeger

doi:10.1074/jbc.M113.531327

The cysteine-rich region of type VII collagen is a cystine knot with a new topology

Henrik Wegener, Hauke Paulsen, Karsten Seeger

Abstract

Background: Type VII collagen is essential for skin stability as highlighted by related skin blistering diseases.Results: A fusion protein comprising the cysteine-rich region and parts of the flanking domains forms a trimer upon oxidization.Conclusion: The cysteine-rich region is an N-terminal cystine knot with novel topology.Significance: The cystine knot is also found in type IX collagen, indicating a general principle.

Originalsprache	Englisch
Titel	Journal of Biological Chemistry
Seitenumfang	9
Herausgeber (Verlag)	American Society for Biochemistry and Molecular Biology Inc.
Erscheinungsdatum	21.02.2014
Seiten	4861-4869
ISBN (Print)	1083-351X (Electronic)\r0021-9258 (Linking)
DOIs	https://doi.org/10.1074/jbc.M113.531327
Publikationsstatus	Veröffentlicht - 21.02.2014

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10.1074/jbc.M113.531327

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title = "The cysteine-rich region of type VII collagen is a cystine knot with a new topology",

abstract = "Background: Type VII collagen is essential for skin stability as highlighted by related skin blistering diseases.Results: A fusion protein comprising the cysteine-rich region and parts of the flanking domains forms a trimer upon oxidization.Conclusion: The cysteine-rich region is an N-terminal cystine knot with novel topology.Significance: The cystine knot is also found in type IX collagen, indicating a general principle.",

author = "Henrik Wegener and Hauke Paulsen and Karsten Seeger",

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doi = "10.1074/jbc.M113.531327",

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The cysteine-rich region of type VII collagen is a cystine knot with a new topology. / Wegener, Henrik; Paulsen, Hauke ; Seeger, Karsten.
Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology Inc., 2014. S. 4861-4869 (Journal of Biological Chemistry; Band 289).

Publikation: Kapitel in Büchern/Berichten/Konferenzbänden › Kapitel › Begutachtung

TY - CHAP

T1 - The cysteine-rich region of type VII collagen is a cystine knot with a new topology

AU - Wegener, Henrik

AU - Paulsen, Hauke

AU - Seeger, Karsten

PY - 2014/2/21

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N2 - Background: Type VII collagen is essential for skin stability as highlighted by related skin blistering diseases.Results: A fusion protein comprising the cysteine-rich region and parts of the flanking domains forms a trimer upon oxidization.Conclusion: The cysteine-rich region is an N-terminal cystine knot with novel topology.Significance: The cystine knot is also found in type IX collagen, indicating a general principle.

AB - Background: Type VII collagen is essential for skin stability as highlighted by related skin blistering diseases.Results: A fusion protein comprising the cysteine-rich region and parts of the flanking domains forms a trimer upon oxidization.Conclusion: The cysteine-rich region is an N-terminal cystine knot with novel topology.Significance: The cystine knot is also found in type IX collagen, indicating a general principle.

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DO - 10.1074/jbc.M113.531327

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SN - 1083-351X (Electronic)\r0021-9258 (Linking)

T3 - Journal of Biological Chemistry

SP - 4861

EP - 4869

BT - Journal of Biological Chemistry

PB - American Society for Biochemistry and Molecular Biology Inc.

ER -

The cysteine-rich region of type VII collagen is a cystine knot with a new topology

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