Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Eva Rial-Pensado; Verónica Rivas-Limeres; Carmen Grijota-Martínez; Amanda Rodríguez-Díaz; Valentina Capelli; Olga Barca-Mayo; Rubén Nogueiras; Jens Mittag; Carlos Diéguez; Miguel López

doi:10.3389/fphys.2022.1017381

Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Eva Rial-Pensado, Verónica Rivas-Limeres, Carmen Grijota-Martínez, Amanda Rodríguez-Díaz, Valentina Capelli, Olga Barca-Mayo, Rubén Nogueiras, Jens Mittag, Carlos Diéguez^*, Miguel López^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Endokrinologie und Diabetes

6 Zitate (Scopus)

Abstract

Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.

Originalsprache	Englisch
Aufsatznummer	1017381
Zeitschrift	Frontiers in Physiology
Jahrgang	13
ISSN	1664-042X
DOIs	https://doi.org/10.3389/fphys.2022.1017381
Publikationsstatus	Veröffentlicht - 18.11.2022

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

2.22-17 Endokrinologie, Diabetologie, Metabolismus

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Dokumente

10.3389/fphys.2022.1017381

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Link to publication in Scopus

SFB/Transregio TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung
Führer-Sakel, D. (Sprecher*in, Koordinator*in), Mittag, J. (Stellv. Sprecher*in, Stellv. Koordinator*in), Kühnen, P. (Stellv. Sprecher*in, Stellv. Koordinator*in), Heuer, H. (Projektleiter*in (PI)), Schwaninger, M. (Projektleiter*in (PI)), Müller-Fielitz, H. (Projektleiter*in (PI)), Bechmann, I. (Projektleiter*in (PI)), Biebermann, H. (Projektleiter*in (PI)), Müller, T. (Projektleiter*in (PI)), Pfluger, P. (Projektleiter*in (PI)), Krude, H. (Projektleiter*in (PI)), Schülke-Gerstenfeld, M. (Projektleiter*in (PI)), Cirkel, A. (Projektleiter*in (PI)), Münte, T. (Projektleiter*in (PI)), Kleinschnitz, C. (Projektleiter*in (PI)), Langhauser, F. (Projektleiter*in (PI)), Engel, D. R. (Projektleiter*in (PI)), Möller, L. (Projektleiter*in (PI)), Kaiser, F. (Projektleiter*in (PI)), Oster, H. (Projektleiter*in (PI)), Kirchner, H. (Projektleiter*in (PI)), Spranger, J. (Projektleiter*in (PI)), Tacke, F. (Projektleiter*in (PI)), Wirth, E. K. (Projektleiter*in (PI)), Köhrle, J. (Projektleiter*in (PI)), Schomburg, L. (Projektleiter*in (PI)), Lange, C. M. (Projektleiter*in (PI)), Zwanziger, D. (Projektleiter*in (PI)), Mayerl, S. (Projektleiter*in (PI)) & Stachelscheid, H. (Projektleiter*in (PI))
01.01.20 → …
Projekt: DFG-Projekte › DFG-Verbundforschung: Sonderforschungsbereiche/ Transregios

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title = "Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis",

abstract = "Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.",

author = "Eva Rial-Pensado and Ver{\'o}nica Rivas-Limeres and Carmen Grijota-Mart{\'i}nez and Amanda Rodr{\'i}guez-D{\'i}az and Valentina Capelli and Olga Barca-Mayo and Rub{\'e}n Nogueiras and Jens Mittag and Carlos Di{\'e}guez and Miguel L{\'o}pez",

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AU - Rial-Pensado, Eva

AU - Rivas-Limeres, Verónica

AU - Grijota-Martínez, Carmen

AU - Rodríguez-Díaz, Amanda

AU - Capelli, Valentina

AU - Barca-Mayo, Olga

AU - Nogueiras, Rubén

AU - Mittag, Jens

AU - Diéguez, Carlos

AU - López, Miguel

PY - 2022/11/18

Y1 - 2022/11/18

N2 - Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.

AB - Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.

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Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Abstract

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

UN SDGs

Dokumente

Weitere Links

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Projekte

SFB/Transregio TRR 296 LocoTact: Lokale Kontrolle der Schilddrüsenhormonwirkung

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